Neoantigen-specific T cell help outperforms non-specific help in multi-antigen DNA vaccination against cancer

Neoantigen-specific T cell help outperforms non-specific help in multi-antigen DNA vaccination against cancer

CD4+ T helper antigens are essential components of cancer vaccines, but the relevance of the source of these MHC class II-restricted antigens remains underexplored. To compare the effectiveness of tumor-specific versus tumor-unrelated helper antigens, we designed three DNA vaccines for the murine MC...

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Bibliographic Details
Main Authors: Joanna Fréderique de Graaf, Tamara Pesic, Felicia S. Spitzer, Koen Oosterhuis, Marcel G.M. Camps, Iris Zoutendijk, Bram Teunisse, Wahwah Zhu, Tsolere Arakelian, Gerben C. Zondag, Ramon Arens, Jeroen van Bergen, Ferry Ossendorp
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
DNA vaccine
cancer vaccine
neoantigens
personalized medicine
immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000778
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