First Report of the L925I kdr Mutation Associated with Pyrethroid Resistance in Genetically Distinct <i>Triatoma dimidiata</i>, Vector of Chagas Disease in Mexico
<i>Triatoma dimidiata</i> is a widely distributed vector of <i>Trypanosoma cruzi</i> in Mexico and Central America, found across a range of habitats from sylvatic to domestic. Vector control has relied heavily on indoor residual spraying with pyrethroids; however, reinfestati...
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MDPI AG
2025-06-01
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| author | Mario C. Saucedo-Montalvo Jesus A. Davila-Barboza Selene M. Gutierrez-Rodriguez Beatriz Lopez-Monroy Susana Favela-Lara Iram P. Rodriguez-Sanchez Guadalupe del C. Reyes-Solis Cristina Bobadilla-Utrera Adriana E. Flores |
| author_facet | Mario C. Saucedo-Montalvo Jesus A. Davila-Barboza Selene M. Gutierrez-Rodriguez Beatriz Lopez-Monroy Susana Favela-Lara Iram P. Rodriguez-Sanchez Guadalupe del C. Reyes-Solis Cristina Bobadilla-Utrera Adriana E. Flores |
| author_sort | Mario C. Saucedo-Montalvo |
| collection | DOAJ |
| description | <i>Triatoma dimidiata</i> is a widely distributed vector of <i>Trypanosoma cruzi</i> in Mexico and Central America, found across a range of habitats from sylvatic to domestic. Vector control has relied heavily on indoor residual spraying with pyrethroids; however, reinfestation and emerging resistance have limited its long-term effectiveness. In this study, we analyzed the genetic diversity and population structure of <i>T. dimidiata</i> from Veracruz, Oaxaca, and Yucatan using mitochondrial markers (cyt b and ND4) and screened for knockdown resistance (kdr)-type mutations in the voltage-gated sodium channel (VGSC) gene. High haplotype diversity and regional differentiation were observed, with most genetic variation occurring between populations. The ND4 marker provided greater resolution than cyt b, revealing ten haplotypes and supporting evidence of recent population expansion. Haplotype networks showed clear geographic segregation, particularly between populations east and west of the Isthmus of Tehuantepec. The L925I mutation, highly associated with pyrethroid resistance, was detected for the first time in Mexican populations of <i>T. dimidiata</i>, albeit at low frequencies. These findings highlight the importance of integrating population genetic data and resistance surveillance into regionally adapted vector control strategies for Chagas disease. |
| format | Article |
| id | doaj-art-e92ac5ee40f449debdab73b0f3bf746a |
| institution | DOAJ |
| issn | 2414-6366 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj-art-e92ac5ee40f449debdab73b0f3bf746a2025-08-20T03:08:00ZengMDPI AGTropical Medicine and Infectious Disease2414-63662025-06-0110718210.3390/tropicalmed10070182First Report of the L925I kdr Mutation Associated with Pyrethroid Resistance in Genetically Distinct <i>Triatoma dimidiata</i>, Vector of Chagas Disease in MexicoMario C. Saucedo-Montalvo0Jesus A. Davila-Barboza1Selene M. Gutierrez-Rodriguez2Beatriz Lopez-Monroy3Susana Favela-Lara4Iram P. Rodriguez-Sanchez5Guadalupe del C. Reyes-Solis6Cristina Bobadilla-Utrera7Adriana E. Flores8Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, Av. Universidad s/n Cd. Universitaria, San Nicolas de los Garza NL 66455, MexicoFacultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, Av. Universidad s/n Cd. Universitaria, San Nicolas de los Garza NL 66455, MexicoFacultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, Av. Universidad s/n Cd. Universitaria, San Nicolas de los Garza NL 66455, MexicoFacultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, Av. Universidad s/n Cd. Universitaria, San Nicolas de los Garza NL 66455, MexicoFacultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, Av. Universidad s/n Cd. Universitaria, San Nicolas de los Garza NL 66455, MexicoFacultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, Av. Universidad s/n Cd. Universitaria, San Nicolas de los Garza NL 66455, MexicoCentro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autonoma de Yucatan, Merida 97000, Yucatan, MexicoLaboratorio Estatal de Salud Publica, Servicios de Salud de Veracruz, Veracruz 91697, MexicoFacultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, Av. Universidad s/n Cd. Universitaria, San Nicolas de los Garza NL 66455, Mexico<i>Triatoma dimidiata</i> is a widely distributed vector of <i>Trypanosoma cruzi</i> in Mexico and Central America, found across a range of habitats from sylvatic to domestic. Vector control has relied heavily on indoor residual spraying with pyrethroids; however, reinfestation and emerging resistance have limited its long-term effectiveness. In this study, we analyzed the genetic diversity and population structure of <i>T. dimidiata</i> from Veracruz, Oaxaca, and Yucatan using mitochondrial markers (cyt b and ND4) and screened for knockdown resistance (kdr)-type mutations in the voltage-gated sodium channel (VGSC) gene. High haplotype diversity and regional differentiation were observed, with most genetic variation occurring between populations. The ND4 marker provided greater resolution than cyt b, revealing ten haplotypes and supporting evidence of recent population expansion. Haplotype networks showed clear geographic segregation, particularly between populations east and west of the Isthmus of Tehuantepec. The L925I mutation, highly associated with pyrethroid resistance, was detected for the first time in Mexican populations of <i>T. dimidiata</i>, albeit at low frequencies. These findings highlight the importance of integrating population genetic data and resistance surveillance into regionally adapted vector control strategies for Chagas disease.https://www.mdpi.com/2414-6366/10/7/182<i>Triatoma dimidiata</i>genetic structuremitochondrial markersknockdown resistanceL925I mutation |
| spellingShingle | Mario C. Saucedo-Montalvo Jesus A. Davila-Barboza Selene M. Gutierrez-Rodriguez Beatriz Lopez-Monroy Susana Favela-Lara Iram P. Rodriguez-Sanchez Guadalupe del C. Reyes-Solis Cristina Bobadilla-Utrera Adriana E. Flores First Report of the L925I kdr Mutation Associated with Pyrethroid Resistance in Genetically Distinct <i>Triatoma dimidiata</i>, Vector of Chagas Disease in Mexico Tropical Medicine and Infectious Disease <i>Triatoma dimidiata</i> genetic structure mitochondrial markers knockdown resistance L925I mutation |
| title | First Report of the L925I kdr Mutation Associated with Pyrethroid Resistance in Genetically Distinct <i>Triatoma dimidiata</i>, Vector of Chagas Disease in Mexico |
| title_full | First Report of the L925I kdr Mutation Associated with Pyrethroid Resistance in Genetically Distinct <i>Triatoma dimidiata</i>, Vector of Chagas Disease in Mexico |
| title_fullStr | First Report of the L925I kdr Mutation Associated with Pyrethroid Resistance in Genetically Distinct <i>Triatoma dimidiata</i>, Vector of Chagas Disease in Mexico |
| title_full_unstemmed | First Report of the L925I kdr Mutation Associated with Pyrethroid Resistance in Genetically Distinct <i>Triatoma dimidiata</i>, Vector of Chagas Disease in Mexico |
| title_short | First Report of the L925I kdr Mutation Associated with Pyrethroid Resistance in Genetically Distinct <i>Triatoma dimidiata</i>, Vector of Chagas Disease in Mexico |
| title_sort | first report of the l925i kdr mutation associated with pyrethroid resistance in genetically distinct i triatoma dimidiata i vector of chagas disease in mexico |
| topic | <i>Triatoma dimidiata</i> genetic structure mitochondrial markers knockdown resistance L925I mutation |
| url | https://www.mdpi.com/2414-6366/10/7/182 |
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