Comparative safety and effectiveness of cryoballoon versus radiofrequency ablation for atrial fibrillation: a systematic review and meta-analysis
Abstract Background Over the past fifty years, the incidence of atrial fibrillation (AF) has tripled. Traditionally, the main treatment for this condition has been pulmonary vein isolation (PVI) performed using radiofrequency catheter ablation (RFCA). However, another technique known as cryoballoon...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-02-01
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| Series: | The Egyptian Heart Journal |
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| Online Access: | https://doi.org/10.1186/s43044-025-00611-9 |
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| author | Muhammad Furqan Ifrah Inbisat Raza Shaheera Younus Hareer Fatima Hiba Azhar Sania Kaneez Fatima Laiba Ali Sara Khan Aayat Ellahi |
| author_facet | Muhammad Furqan Ifrah Inbisat Raza Shaheera Younus Hareer Fatima Hiba Azhar Sania Kaneez Fatima Laiba Ali Sara Khan Aayat Ellahi |
| author_sort | Muhammad Furqan |
| collection | DOAJ |
| description | Abstract Background Over the past fifty years, the incidence of atrial fibrillation (AF) has tripled. Traditionally, the main treatment for this condition has been pulmonary vein isolation (PVI) performed using radiofrequency catheter ablation (RFCA). However, another technique known as cryoballoon ablation (CBA) has been developed as another option for managing this heart rhythm disorder. This study evaluated the efficacy and safety of CBA and RFCA for the treatment of AF. Methods This study compared the safety and effectiveness of CBA and RFCA for the treatment of AF using a thorough review of randomized controlled trials up until June 1, 2023. Results The results revealed that CBA and RFCA had similar effectiveness and safety profiles in achieving freedom from AF (RR: 1.00; 95% CI: 0.93 to 1.07, p = 0.99) and paroxysmal atrial fibrillation (PAF) (RR: 0.99; 95% CI: 0.89 to 1.10, p = 0.79). CBA was faster (MD = − 23.99; 95% CI: − 32.98 to − 15.00; p < 0.00001) with a higher risk of phrenic nerve palsy (RR = 6.88; 95% CI: 3.26 to 14.50, p < 0.00001). Acute PVI rate (RR = 1.0; 95% CI: 0.99 to 1.01, p = 0.95), overall complications (RR = 1.37; 95% CI: 0.93 to 2.01, p = 0.11), pericardial effusion (RR = 0.59; 95% CI: 0.25 to 1.41, p = 0.24), and fluoroscopy time (MD = 1.63; 95% CI: − 2.06 5.32; p = 0.39) did not significantly differ between the two procedures. Conclusions CBA and RFCA offer similar outcomes for patients with AF and PAF, with CBA being quicker but carrying a slightly higher risk of phrenic nerve palsy. |
| format | Article |
| id | doaj-art-e92a5ce7634b41b0b4f684fcaaa9280d |
| institution | Kabale University |
| issn | 2090-911X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj-art-e92a5ce7634b41b0b4f684fcaaa9280d2025-02-09T12:43:15ZengSpringerOpenThe Egyptian Heart Journal2090-911X2025-02-0177111210.1186/s43044-025-00611-9Comparative safety and effectiveness of cryoballoon versus radiofrequency ablation for atrial fibrillation: a systematic review and meta-analysisMuhammad Furqan0Ifrah Inbisat Raza1Shaheera Younus2Hareer Fatima3Hiba Azhar4Sania Kaneez Fatima5Laiba Ali6Sara Khan7Aayat Ellahi8Department of Internal Medicine, Student of Medicine, King Edward Medical University, Neela GumbadDepartment of Medicine, Student of Medicine, Jinnah Sindh Medical UniversityDepartment of Medicine, Student of Medicine, Jinnah Sindh Medical UniversityDepartment of Medicine, Student of Medicine, Jinnah Sindh Medical UniversityDepartment of Medicine, Student of Medicine, Jinnah Sindh Medical UniversityDepartment of Medicine, Student of Medicine, Jinnah Sindh Medical UniversityDepartment of Medicine, Student of Medicine, Jinnah Sindh Medical UniversityDepartment of Medicine, Student of Medicine, Jinnah Sindh Medical UniversityDepartment of Medicine, Student of Medicine, Jinnah Sindh Medical UniversityAbstract Background Over the past fifty years, the incidence of atrial fibrillation (AF) has tripled. Traditionally, the main treatment for this condition has been pulmonary vein isolation (PVI) performed using radiofrequency catheter ablation (RFCA). However, another technique known as cryoballoon ablation (CBA) has been developed as another option for managing this heart rhythm disorder. This study evaluated the efficacy and safety of CBA and RFCA for the treatment of AF. Methods This study compared the safety and effectiveness of CBA and RFCA for the treatment of AF using a thorough review of randomized controlled trials up until June 1, 2023. Results The results revealed that CBA and RFCA had similar effectiveness and safety profiles in achieving freedom from AF (RR: 1.00; 95% CI: 0.93 to 1.07, p = 0.99) and paroxysmal atrial fibrillation (PAF) (RR: 0.99; 95% CI: 0.89 to 1.10, p = 0.79). CBA was faster (MD = − 23.99; 95% CI: − 32.98 to − 15.00; p < 0.00001) with a higher risk of phrenic nerve palsy (RR = 6.88; 95% CI: 3.26 to 14.50, p < 0.00001). Acute PVI rate (RR = 1.0; 95% CI: 0.99 to 1.01, p = 0.95), overall complications (RR = 1.37; 95% CI: 0.93 to 2.01, p = 0.11), pericardial effusion (RR = 0.59; 95% CI: 0.25 to 1.41, p = 0.24), and fluoroscopy time (MD = 1.63; 95% CI: − 2.06 5.32; p = 0.39) did not significantly differ between the two procedures. Conclusions CBA and RFCA offer similar outcomes for patients with AF and PAF, with CBA being quicker but carrying a slightly higher risk of phrenic nerve palsy.https://doi.org/10.1186/s43044-025-00611-9Atrial fibrillationParoxysmal atrial fibrillationPulmonary vein isolationCryoballoonRadiofrequency ablation |
| spellingShingle | Muhammad Furqan Ifrah Inbisat Raza Shaheera Younus Hareer Fatima Hiba Azhar Sania Kaneez Fatima Laiba Ali Sara Khan Aayat Ellahi Comparative safety and effectiveness of cryoballoon versus radiofrequency ablation for atrial fibrillation: a systematic review and meta-analysis The Egyptian Heart Journal Atrial fibrillation Paroxysmal atrial fibrillation Pulmonary vein isolation Cryoballoon Radiofrequency ablation |
| title | Comparative safety and effectiveness of cryoballoon versus radiofrequency ablation for atrial fibrillation: a systematic review and meta-analysis |
| title_full | Comparative safety and effectiveness of cryoballoon versus radiofrequency ablation for atrial fibrillation: a systematic review and meta-analysis |
| title_fullStr | Comparative safety and effectiveness of cryoballoon versus radiofrequency ablation for atrial fibrillation: a systematic review and meta-analysis |
| title_full_unstemmed | Comparative safety and effectiveness of cryoballoon versus radiofrequency ablation for atrial fibrillation: a systematic review and meta-analysis |
| title_short | Comparative safety and effectiveness of cryoballoon versus radiofrequency ablation for atrial fibrillation: a systematic review and meta-analysis |
| title_sort | comparative safety and effectiveness of cryoballoon versus radiofrequency ablation for atrial fibrillation a systematic review and meta analysis |
| topic | Atrial fibrillation Paroxysmal atrial fibrillation Pulmonary vein isolation Cryoballoon Radiofrequency ablation |
| url | https://doi.org/10.1186/s43044-025-00611-9 |
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