Emerging role of HJURP as a therapeutic target in cancers
Holliday junction recognition protein (HJURP) is a key molecular chaperone for centromere protein A (CENP-A), which is essential for chromosome separation during mitosis and cell cycle regulation. Recent studies have identified the essential role of HJURP in carcinogenesis. Abnormal upregulation of...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Compuscript Ltd
2023-04-01
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| Series: | Acta Materia Medica |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0008 |
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| author | Jiaqi Tan Lertnimitphun Peeraphong Chattarin Ruchawapol Juan Zhang Juan Zhao Wenwei Fu Li Zhang Hongxi Xu |
| author_facet | Jiaqi Tan Lertnimitphun Peeraphong Chattarin Ruchawapol Juan Zhang Juan Zhao Wenwei Fu Li Zhang Hongxi Xu |
| author_sort | Jiaqi Tan |
| collection | DOAJ |
| description | Holliday junction recognition protein (HJURP) is a key molecular chaperone for centromere protein A (CENP-A), which is essential for chromosome separation during mitosis and cell cycle regulation. Recent studies have identified the essential role of HJURP in carcinogenesis. Abnormal upregulation of HJURP expression has been observed in various human cancers, such as non-small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), bladder cancer, and breast cancer, and is associated with poor pathologic development and prognosis. In vitro and in vivo studies have shown that HJURP mainly exerts oncogenic functions by regulating the cell cycle, cellular senescence, and epithelial-mesenchymal transition (EMT). The purpose of this review was to evaluate the prognostic significance of HJURP in human cancers and summarize anti-tumor studies targeting HJURP. The factors regulating HJURP in carcinogenesis and the corresponding effects are also discussed to provide new insight into targeting HJURP as a promising strategy for cancer treatment. |
| format | Article |
| id | doaj-art-e929c608049a4250892d9016398594ff |
| institution | Kabale University |
| issn | 2737-7946 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Acta Materia Medica |
| spelling | doaj-art-e929c608049a4250892d9016398594ff2025-08-20T03:27:15ZengCompuscript LtdActa Materia Medica2737-79462023-04-012215717110.15212/AMM-2023-0008Emerging role of HJURP as a therapeutic target in cancersJiaqi TanLertnimitphun PeeraphongChattarin RuchawapolJuan ZhangJuan ZhaoWenwei FuLi ZhangHongxi XuHolliday junction recognition protein (HJURP) is a key molecular chaperone for centromere protein A (CENP-A), which is essential for chromosome separation during mitosis and cell cycle regulation. Recent studies have identified the essential role of HJURP in carcinogenesis. Abnormal upregulation of HJURP expression has been observed in various human cancers, such as non-small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), bladder cancer, and breast cancer, and is associated with poor pathologic development and prognosis. In vitro and in vivo studies have shown that HJURP mainly exerts oncogenic functions by regulating the cell cycle, cellular senescence, and epithelial-mesenchymal transition (EMT). The purpose of this review was to evaluate the prognostic significance of HJURP in human cancers and summarize anti-tumor studies targeting HJURP. The factors regulating HJURP in carcinogenesis and the corresponding effects are also discussed to provide new insight into targeting HJURP as a promising strategy for cancer treatment.https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0008 |
| spellingShingle | Jiaqi Tan Lertnimitphun Peeraphong Chattarin Ruchawapol Juan Zhang Juan Zhao Wenwei Fu Li Zhang Hongxi Xu Emerging role of HJURP as a therapeutic target in cancers Acta Materia Medica |
| title | Emerging role of HJURP as a therapeutic target in cancers |
| title_full | Emerging role of HJURP as a therapeutic target in cancers |
| title_fullStr | Emerging role of HJURP as a therapeutic target in cancers |
| title_full_unstemmed | Emerging role of HJURP as a therapeutic target in cancers |
| title_short | Emerging role of HJURP as a therapeutic target in cancers |
| title_sort | emerging role of hjurp as a therapeutic target in cancers |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0008 |
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