Clinical Predictors of <i>Escherichia coli</i> Versus <i>Staphylococcus aureus</i> Bacteremia at the Emergency Department
<b>Background:</b> Bacteremia is a life-threatening condition encountered in the emergency department (ED). <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> are among the most common pathogens, but early differentiation is challenging. Identifying clinical...
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MDPI AG
2025-06-01
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| author | Pariwat Phungoen Thanat Tangpaisarn Kittisak Sawanyawisuth |
| author_facet | Pariwat Phungoen Thanat Tangpaisarn Kittisak Sawanyawisuth |
| author_sort | Pariwat Phungoen |
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| description | <b>Background:</b> Bacteremia is a life-threatening condition encountered in the emergency department (ED). <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> are among the most common pathogens, but early differentiation is challenging. Identifying clinical predictors may help guide empirical treatment while awaiting culture results. <b>Methods:</b> This retrospective analytical study included adults aged 18 years or older who presented with bacteremia in the ED between 1 January 2016 and 31 December 2018 and had blood cultures positive for either <i>S. aureus</i> or <i>E. coli</i>. Clinical predictors of <i>E. coli</i> bacteremia were identified using multivariable logistic regression analysis. <b>Results:</b> Among 327 patients, 272 (83.2%) had <i>E. coli</i> bacteremia. Significant predictors of <i>E. coli</i> bacteremia included hypertension (adjusted OR 2.12; 95% CI: 1.03–4.39; <i>p</i> = 0.041), solid organ tumor (adjusted OR 3.72; 95% CI: 1.63–8.51; <i>p</i> = 0.002), and higher body temperature (adjusted OR 1.49 per °C; 95% CI: 1.15–1.93; <i>p</i> = 0.002). The model showed good fit (Hosmer–Lemeshow <i>p</i> = 0.326). <b>Conclusions:</b> Patients presenting with hypertension, solid organ tumor, or elevated body temperature at the ED are more likely to have <i>E. coli</i> bacteremia than <i>S. aureus</i>. These predictors may support early empirical antibiotic decision-making. |
| format | Article |
| id | doaj-art-e928b04e1329479a8f561588adffdd84 |
| institution | DOAJ |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-06-01 |
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| series | Antibiotics |
| spelling | doaj-art-e928b04e1329479a8f561588adffdd842025-08-20T02:45:52ZengMDPI AGAntibiotics2079-63822025-06-0114765410.3390/antibiotics14070654Clinical Predictors of <i>Escherichia coli</i> Versus <i>Staphylococcus aureus</i> Bacteremia at the Emergency DepartmentPariwat Phungoen0Thanat Tangpaisarn1Kittisak Sawanyawisuth2Department of Emergency Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Emergency Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand<b>Background:</b> Bacteremia is a life-threatening condition encountered in the emergency department (ED). <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> are among the most common pathogens, but early differentiation is challenging. Identifying clinical predictors may help guide empirical treatment while awaiting culture results. <b>Methods:</b> This retrospective analytical study included adults aged 18 years or older who presented with bacteremia in the ED between 1 January 2016 and 31 December 2018 and had blood cultures positive for either <i>S. aureus</i> or <i>E. coli</i>. Clinical predictors of <i>E. coli</i> bacteremia were identified using multivariable logistic regression analysis. <b>Results:</b> Among 327 patients, 272 (83.2%) had <i>E. coli</i> bacteremia. Significant predictors of <i>E. coli</i> bacteremia included hypertension (adjusted OR 2.12; 95% CI: 1.03–4.39; <i>p</i> = 0.041), solid organ tumor (adjusted OR 3.72; 95% CI: 1.63–8.51; <i>p</i> = 0.002), and higher body temperature (adjusted OR 1.49 per °C; 95% CI: 1.15–1.93; <i>p</i> = 0.002). The model showed good fit (Hosmer–Lemeshow <i>p</i> = 0.326). <b>Conclusions:</b> Patients presenting with hypertension, solid organ tumor, or elevated body temperature at the ED are more likely to have <i>E. coli</i> bacteremia than <i>S. aureus</i>. These predictors may support early empirical antibiotic decision-making.https://www.mdpi.com/2079-6382/14/7/654bacteremia<i>E. coli</i><i>S. aureus</i>solid organ tumor |
| spellingShingle | Pariwat Phungoen Thanat Tangpaisarn Kittisak Sawanyawisuth Clinical Predictors of <i>Escherichia coli</i> Versus <i>Staphylococcus aureus</i> Bacteremia at the Emergency Department Antibiotics bacteremia <i>E. coli</i> <i>S. aureus</i> solid organ tumor |
| title | Clinical Predictors of <i>Escherichia coli</i> Versus <i>Staphylococcus aureus</i> Bacteremia at the Emergency Department |
| title_full | Clinical Predictors of <i>Escherichia coli</i> Versus <i>Staphylococcus aureus</i> Bacteremia at the Emergency Department |
| title_fullStr | Clinical Predictors of <i>Escherichia coli</i> Versus <i>Staphylococcus aureus</i> Bacteremia at the Emergency Department |
| title_full_unstemmed | Clinical Predictors of <i>Escherichia coli</i> Versus <i>Staphylococcus aureus</i> Bacteremia at the Emergency Department |
| title_short | Clinical Predictors of <i>Escherichia coli</i> Versus <i>Staphylococcus aureus</i> Bacteremia at the Emergency Department |
| title_sort | clinical predictors of i escherichia coli i versus i staphylococcus aureus i bacteremia at the emergency department |
| topic | bacteremia <i>E. coli</i> <i>S. aureus</i> solid organ tumor |
| url | https://www.mdpi.com/2079-6382/14/7/654 |
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