The Effect of Acid-Reducing Pharmacotherapy on the Severity of Nausea and Vomiting of Pregnancy
Background. Heartburn and acid reflux (HB/RF) are associated with increased severity of nausea and vomiting. The ability of acid-reducing drugs to reduce symptoms of nausea and vomiting of pregnancy has not been previously tested. Objective. To determine whether acid-reducing pharmacotherapy decreas...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2009/585269 |
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| author | Simerpal Kaur Gill Caroline Maltepe Katayoon Mastali Gideon Koren |
| author_facet | Simerpal Kaur Gill Caroline Maltepe Katayoon Mastali Gideon Koren |
| author_sort | Simerpal Kaur Gill |
| collection | DOAJ |
| description | Background. Heartburn and acid reflux (HB/RF) are associated with increased severity of nausea and vomiting. The ability of acid-reducing drugs to reduce symptoms of nausea and vomiting of pregnancy has not been previously tested. Objective. To determine whether acid-reducing pharmacotherapy decreases the severity of NVP symptoms. Methods. We studied a cohort of women experiencing NVP, who were also experiencing HB/RF. Women were counseled to commence acid-reducing pharmacotherapy. The effectiveness of the acid-reducing medication in decreasing symptoms of both HB/RF and NVP was measured. Results. Acid-reducing drugs resulted in significant decreases in PUQE (9.6±3.0 to 6.5±2.5, P<.0001) and well-being scores from the initial (4.0±2.0) to the follow-up interview (6.8±1.6, P<.0001). After intervention with acid-reducing pharmacotherapy, a reduction in acid symptoms correlated significantly with reduction in NVP (R2=0.72, P<.001). Conclusion. This is the first study to demonstrate that management of HB/RF can reduce the severity of NVP. |
| format | Article |
| id | doaj-art-e9239d011be6420a950d5743f925bd3d |
| institution | DOAJ |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-e9239d011be6420a950d5743f925bd3d2025-08-20T03:21:09ZengWileyObstetrics and Gynecology International1687-95891687-95972009-01-01200910.1155/2009/585269585269The Effect of Acid-Reducing Pharmacotherapy on the Severity of Nausea and Vomiting of PregnancySimerpal Kaur Gill0Caroline Maltepe1Katayoon Mastali2Gideon Koren3The Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, CanadaThe Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, CanadaThe Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, CanadaThe Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, CanadaBackground. Heartburn and acid reflux (HB/RF) are associated with increased severity of nausea and vomiting. The ability of acid-reducing drugs to reduce symptoms of nausea and vomiting of pregnancy has not been previously tested. Objective. To determine whether acid-reducing pharmacotherapy decreases the severity of NVP symptoms. Methods. We studied a cohort of women experiencing NVP, who were also experiencing HB/RF. Women were counseled to commence acid-reducing pharmacotherapy. The effectiveness of the acid-reducing medication in decreasing symptoms of both HB/RF and NVP was measured. Results. Acid-reducing drugs resulted in significant decreases in PUQE (9.6±3.0 to 6.5±2.5, P<.0001) and well-being scores from the initial (4.0±2.0) to the follow-up interview (6.8±1.6, P<.0001). After intervention with acid-reducing pharmacotherapy, a reduction in acid symptoms correlated significantly with reduction in NVP (R2=0.72, P<.001). Conclusion. This is the first study to demonstrate that management of HB/RF can reduce the severity of NVP.http://dx.doi.org/10.1155/2009/585269 |
| spellingShingle | Simerpal Kaur Gill Caroline Maltepe Katayoon Mastali Gideon Koren The Effect of Acid-Reducing Pharmacotherapy on the Severity of Nausea and Vomiting of Pregnancy Obstetrics and Gynecology International |
| title | The Effect of Acid-Reducing Pharmacotherapy on the Severity of Nausea and Vomiting of Pregnancy |
| title_full | The Effect of Acid-Reducing Pharmacotherapy on the Severity of Nausea and Vomiting of Pregnancy |
| title_fullStr | The Effect of Acid-Reducing Pharmacotherapy on the Severity of Nausea and Vomiting of Pregnancy |
| title_full_unstemmed | The Effect of Acid-Reducing Pharmacotherapy on the Severity of Nausea and Vomiting of Pregnancy |
| title_short | The Effect of Acid-Reducing Pharmacotherapy on the Severity of Nausea and Vomiting of Pregnancy |
| title_sort | effect of acid reducing pharmacotherapy on the severity of nausea and vomiting of pregnancy |
| url | http://dx.doi.org/10.1155/2009/585269 |
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