EBV IN HODGKIN LYMPHOMA
<p class="MsoNormal" style="text-align: justify; line-height: 150%; margin: 0cm 0cm 0pt;"><span style="mso-ansi-language: EN-GB;" lang="EN-GB"><span style="font-size: small;"><span style="font-fam...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2009-11-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Online Access: | http://www.mjhid.org/article/view/5114 |
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| _version_ | 1846095693948649472 |
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| author | Stefan Hohaus Doerte Siemer Giuseppina Massini |
| author_facet | Stefan Hohaus Doerte Siemer Giuseppina Massini |
| author_sort | Stefan Hohaus |
| collection | DOAJ |
| description | <p class="MsoNormal" style="text-align: justify; line-height: 150%; margin: 0cm 0cm 0pt;"><span style="mso-ansi-language: EN-GB;" lang="EN-GB"><span style="font-size: small;"><span style="font-family: Times New Roman;">Up to 40% of Hodgkin lymphoma (HL) cases are associated with the Epstein-Barr virus (EBV). Clonal viral genomes can be found in the HL tumor cells, the Hodgkin Reed-Sternberg cells (HRS). The latent infection results in expression of the viral oncogenes LMP1 and LMP2A which contribute to generate the particular phenotype of the HRS cells. EBV does not only undergo epigenetic changes of its genome during latency, but also induces epigenetic changes in the host genome. The presence of EBV may alter the composition and activity of the immune cells surrounding the HRS cells. EBV favours a<span style="mso-spacerun: yes;"> </span>Th1 reaction, but this attempt at a cell mediated immune response appears to be ineffective. The presence of EBV in HL is associated with several clinicopathological characteristics: It is more frequent in cases with mixed cellular histology, in males, in children and older adults, and in developing countries, while the young-adult onset HL of nodular sclerosis type in industrialized countries is typically EBV-negative. Countries in the Mediterranean area often show<span style="mso-spacerun: yes;"> </span>an intermediate epidemiological pattern. Recent studies suggest a genetic predisposition to develop EBV-associated HL. Circulating EBV-DNA may serve as a biomarker to monitor response to therapy, and eventually, EBV will become a target for therapeutic intervention also in HL.</span></span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 150%; margin: 0cm 0cm 0pt; tab-stops: 329.25pt;"><span style="mso-ansi-language: EN-GB;" lang="EN-GB"><span style="mso-tab-count: 1;"><span style="font-family: Times New Roman; font-size: small;"> �� </span></span></span></p> |
| format | Article |
| id | doaj-art-e921ba9031644a37a1eaf8f165ebd019 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2009-11-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-e921ba9031644a37a1eaf8f165ebd0192025-01-02T09:46:05ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062009-11-0112e2009013e2009013EBV IN HODGKIN LYMPHOMAStefan HohausDoerte SiemerGiuseppina Massini<p class="MsoNormal" style="text-align: justify; line-height: 150%; margin: 0cm 0cm 0pt;"><span style="mso-ansi-language: EN-GB;" lang="EN-GB"><span style="font-size: small;"><span style="font-family: Times New Roman;">Up to 40% of Hodgkin lymphoma (HL) cases are associated with the Epstein-Barr virus (EBV). Clonal viral genomes can be found in the HL tumor cells, the Hodgkin Reed-Sternberg cells (HRS). The latent infection results in expression of the viral oncogenes LMP1 and LMP2A which contribute to generate the particular phenotype of the HRS cells. EBV does not only undergo epigenetic changes of its genome during latency, but also induces epigenetic changes in the host genome. The presence of EBV may alter the composition and activity of the immune cells surrounding the HRS cells. EBV favours a<span style="mso-spacerun: yes;"> </span>Th1 reaction, but this attempt at a cell mediated immune response appears to be ineffective. The presence of EBV in HL is associated with several clinicopathological characteristics: It is more frequent in cases with mixed cellular histology, in males, in children and older adults, and in developing countries, while the young-adult onset HL of nodular sclerosis type in industrialized countries is typically EBV-negative. Countries in the Mediterranean area often show<span style="mso-spacerun: yes;"> </span>an intermediate epidemiological pattern. Recent studies suggest a genetic predisposition to develop EBV-associated HL. Circulating EBV-DNA may serve as a biomarker to monitor response to therapy, and eventually, EBV will become a target for therapeutic intervention also in HL.</span></span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 150%; margin: 0cm 0cm 0pt; tab-stops: 329.25pt;"><span style="mso-ansi-language: EN-GB;" lang="EN-GB"><span style="mso-tab-count: 1;"><span style="font-family: Times New Roman; font-size: small;"> �� </span></span></span></p>http://www.mjhid.org/article/view/5114 |
| spellingShingle | Stefan Hohaus Doerte Siemer Giuseppina Massini EBV IN HODGKIN LYMPHOMA Mediterranean Journal of Hematology and Infectious Diseases |
| title | EBV IN HODGKIN LYMPHOMA |
| title_full | EBV IN HODGKIN LYMPHOMA |
| title_fullStr | EBV IN HODGKIN LYMPHOMA |
| title_full_unstemmed | EBV IN HODGKIN LYMPHOMA |
| title_short | EBV IN HODGKIN LYMPHOMA |
| title_sort | ebv in hodgkin lymphoma |
| url | http://www.mjhid.org/article/view/5114 |
| work_keys_str_mv | AT stefanhohaus ebvinhodgkinlymphoma AT doertesiemer ebvinhodgkinlymphoma AT giuseppinamassini ebvinhodgkinlymphoma |