MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization

MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization

Abstract Background Chronic obstructive pulmonary disease (COPD) is typically characterized by chronic airway inflammation and emphysema. Macrophage polarization plays an important role in COPD, while the precise molecules and mechanisms underpinning it have yet to be fully elucidated. Pulmonary dec...

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Bibliographic Details
Main Authors: Jiaheng Zhang, Yuan Zhan, Zhesong Deng, Shanshan Chen, Ruonan Yang, Yating Zhang, Hao Fu, Qian Huang, Jixing Wu, Yiya Gu, Jungang Xie
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Respiratory Research
Subjects:
Chronic obstructive pulmonary disease
Myotubularin-related protein 14
Macrophage polarization
Inflammation
Emphysema
Online Access:https://doi.org/10.1186/s12931-025-03293-8
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