Common DNA Variants Accurately Rank an Individual of Extreme Height
Polygenic scores (or genetic risk scores) quantify the aggregate of small effects from many common genetic loci that have been associated with a trait through genome-wide association. Polygenic scores were first used successfully in schizophrenia and have since been applied to multiple phenotypes in...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2018/5121540 |
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| _version_ | 1849691018896605184 |
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| author | Corinne E. Sexton Mark T. W. Ebbert Ryan H. Miller Meganne Ferrel Jo Ann T. Tschanz Christopher D. Corcoran Alzheimer’s Disease Neuroimaging Initiative Perry G. Ridge John S. K. Kauwe |
| author_facet | Corinne E. Sexton Mark T. W. Ebbert Ryan H. Miller Meganne Ferrel Jo Ann T. Tschanz Christopher D. Corcoran Alzheimer’s Disease Neuroimaging Initiative Perry G. Ridge John S. K. Kauwe |
| author_sort | Corinne E. Sexton |
| collection | DOAJ |
| description | Polygenic scores (or genetic risk scores) quantify the aggregate of small effects from many common genetic loci that have been associated with a trait through genome-wide association. Polygenic scores were first used successfully in schizophrenia and have since been applied to multiple phenotypes including multiple sclerosis, rheumatoid arthritis, and height. Because human height is an easily-measured and complex polygenic trait, polygenic height scores provide exciting insights into the predictability of aggregate common variant effect on the phenotype. Shawn Bradley is an extremely tall former professional basketball player from Brigham Young University and the National Basketball Association (NBA), measuring 2.29 meters (7′6″, 99.99999th percentile for height) tall, with no known medical conditions. Here, we present a case where a rare combination of common SNPs in one individual results in an extremely high polygenic height score that is correlated with an extreme phenotype. While polygenic scores are not clinically significant in the average case, our findings suggest that for extreme phenotypes, polygenic scores may be more successful for the prediction of individuals. |
| format | Article |
| id | doaj-art-e918345e8be643acbd37886a0a0dcec4 |
| institution | DOAJ |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-e918345e8be643acbd37886a0a0dcec42025-08-20T03:21:09ZengWileyInternational Journal of Genomics2314-436X2314-43782018-01-01201810.1155/2018/51215405121540Common DNA Variants Accurately Rank an Individual of Extreme HeightCorinne E. Sexton0Mark T. W. Ebbert1Ryan H. Miller2Meganne Ferrel3Jo Ann T. Tschanz4Christopher D. Corcoran5Alzheimer’s Disease Neuroimaging Initiative6Perry G. Ridge7John S. K. Kauwe8Department of Biology, Brigham Young University, Provo, UT 84602, USADepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USADepartment of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USADepartment of Biology, Brigham Young University, Provo, UT 84602, USADepartment of Psychology, Utah State University, Logan, UT, USACenter for Epidemiologic Studies, Utah State University, Logan, UT, USAAlzheimer’s Disease Neuroimaging Initiative, University of Southern California, Los Angeles, CA 90089, USADepartment of Biology, Brigham Young University, Provo, UT 84602, USADepartment of Biology, Brigham Young University, Provo, UT 84602, USAPolygenic scores (or genetic risk scores) quantify the aggregate of small effects from many common genetic loci that have been associated with a trait through genome-wide association. Polygenic scores were first used successfully in schizophrenia and have since been applied to multiple phenotypes including multiple sclerosis, rheumatoid arthritis, and height. Because human height is an easily-measured and complex polygenic trait, polygenic height scores provide exciting insights into the predictability of aggregate common variant effect on the phenotype. Shawn Bradley is an extremely tall former professional basketball player from Brigham Young University and the National Basketball Association (NBA), measuring 2.29 meters (7′6″, 99.99999th percentile for height) tall, with no known medical conditions. Here, we present a case where a rare combination of common SNPs in one individual results in an extremely high polygenic height score that is correlated with an extreme phenotype. While polygenic scores are not clinically significant in the average case, our findings suggest that for extreme phenotypes, polygenic scores may be more successful for the prediction of individuals.http://dx.doi.org/10.1155/2018/5121540 |
| spellingShingle | Corinne E. Sexton Mark T. W. Ebbert Ryan H. Miller Meganne Ferrel Jo Ann T. Tschanz Christopher D. Corcoran Alzheimer’s Disease Neuroimaging Initiative Perry G. Ridge John S. K. Kauwe Common DNA Variants Accurately Rank an Individual of Extreme Height International Journal of Genomics |
| title | Common DNA Variants Accurately Rank an Individual of Extreme Height |
| title_full | Common DNA Variants Accurately Rank an Individual of Extreme Height |
| title_fullStr | Common DNA Variants Accurately Rank an Individual of Extreme Height |
| title_full_unstemmed | Common DNA Variants Accurately Rank an Individual of Extreme Height |
| title_short | Common DNA Variants Accurately Rank an Individual of Extreme Height |
| title_sort | common dna variants accurately rank an individual of extreme height |
| url | http://dx.doi.org/10.1155/2018/5121540 |
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