Synthesis and evaluation of the antibacterial activity of Cu(II) and Ni(II) complexes with mixed ligands based on glycine and dicarboxylic acids
A large number of metal complexes have the ability to inhibit bacterial growth. Cu(II) and Ni(II) complexes based on glycine (Gly), itaconic acid (Ita), and oxalic acid (Ox) were synthesized by conventional methods and evaluated for their antibacterial activity. The metal complexes were characteriz...
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Universidad Nacional de Colombia
2024-11-01
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| Series: | Dyna |
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| Online Access: | https://revistas.unal.edu.co/index.php/dyna/article/view/112116 |
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| author | Luisa Fernanda Múnera-Gómez Juan Carlos Muñoz-Acevedo Elizabeth Pabón-Gelves |
| author_facet | Luisa Fernanda Múnera-Gómez Juan Carlos Muñoz-Acevedo Elizabeth Pabón-Gelves |
| author_sort | Luisa Fernanda Múnera-Gómez |
| collection | DOAJ |
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A large number of metal complexes have the ability to inhibit bacterial growth. Cu(II) and Ni(II) complexes based on glycine (Gly), itaconic acid (Ita), and oxalic acid (Ox) were synthesized by conventional methods and evaluated for their antibacterial activity. The metal complexes were characterized by TGA, FTIR, UV-vis spectroscopy, and XRD. The metal: ligands (M:L1:L2) stoichiometry of these complexes is 1:2:2, and coordination around Cu(II) and Ni(II) seems to be octahedral, with the ligands bound through the N atom of the amino group and O atoms of the bridging carboxylate group. These compounds are crystalline and stable at temperatures between 250 to 300°C. The metal complexes were screened for their antibacterial activity against the bacterial species Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, Salmonella, and Escherichia coli. These compounds were shown to have antibacterial activity mainly against gram-positive strains, with a minimum inhibitory concentration of 20 ppm.
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| format | Article |
| id | doaj-art-e9181a24ef134e80b1ed0616898f68ed |
| institution | Kabale University |
| issn | 0012-7353 2346-2183 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Universidad Nacional de Colombia |
| record_format | Article |
| series | Dyna |
| spelling | doaj-art-e9181a24ef134e80b1ed0616898f68ed2025-01-17T17:09:51ZengUniversidad Nacional de ColombiaDyna0012-73532346-21832024-11-019123410.15446/dyna.v91n234.112116Synthesis and evaluation of the antibacterial activity of Cu(II) and Ni(II) complexes with mixed ligands based on glycine and dicarboxylic acidsLuisa Fernanda Múnera-Gómez0https://orcid.org/0009-0006-3097-2849Juan Carlos Muñoz-Acevedo1https://orcid.org/0000-0001-7543-0644Elizabeth Pabón-Gelves2https://orcid.org/0000-0001-8108-7635Universidad Nacional de Colombia, Sede Medellín, Facultad de Ciencias, Departamento de Química. Medellín, Colombia.Instituto de Química. Universidad de Antioquia, Medellín, ColombiaUniversidad Nacional de Colombia, Sede Medellín, Facultad de Ciencias, Departamento de Química. Medellín, Colombia A large number of metal complexes have the ability to inhibit bacterial growth. Cu(II) and Ni(II) complexes based on glycine (Gly), itaconic acid (Ita), and oxalic acid (Ox) were synthesized by conventional methods and evaluated for their antibacterial activity. The metal complexes were characterized by TGA, FTIR, UV-vis spectroscopy, and XRD. The metal: ligands (M:L1:L2) stoichiometry of these complexes is 1:2:2, and coordination around Cu(II) and Ni(II) seems to be octahedral, with the ligands bound through the N atom of the amino group and O atoms of the bridging carboxylate group. These compounds are crystalline and stable at temperatures between 250 to 300°C. The metal complexes were screened for their antibacterial activity against the bacterial species Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, Salmonella, and Escherichia coli. These compounds were shown to have antibacterial activity mainly against gram-positive strains, with a minimum inhibitory concentration of 20 ppm. https://revistas.unal.edu.co/index.php/dyna/article/view/112116complexesamino acidsglycineitaconic acidoxalic acid |
| spellingShingle | Luisa Fernanda Múnera-Gómez Juan Carlos Muñoz-Acevedo Elizabeth Pabón-Gelves Synthesis and evaluation of the antibacterial activity of Cu(II) and Ni(II) complexes with mixed ligands based on glycine and dicarboxylic acids Dyna complexes amino acids glycine itaconic acid oxalic acid |
| title | Synthesis and evaluation of the antibacterial activity of Cu(II) and Ni(II) complexes with mixed ligands based on glycine and dicarboxylic acids |
| title_full | Synthesis and evaluation of the antibacterial activity of Cu(II) and Ni(II) complexes with mixed ligands based on glycine and dicarboxylic acids |
| title_fullStr | Synthesis and evaluation of the antibacterial activity of Cu(II) and Ni(II) complexes with mixed ligands based on glycine and dicarboxylic acids |
| title_full_unstemmed | Synthesis and evaluation of the antibacterial activity of Cu(II) and Ni(II) complexes with mixed ligands based on glycine and dicarboxylic acids |
| title_short | Synthesis and evaluation of the antibacterial activity of Cu(II) and Ni(II) complexes with mixed ligands based on glycine and dicarboxylic acids |
| title_sort | synthesis and evaluation of the antibacterial activity of cu ii and ni ii complexes with mixed ligands based on glycine and dicarboxylic acids |
| topic | complexes amino acids glycine itaconic acid oxalic acid |
| url | https://revistas.unal.edu.co/index.php/dyna/article/view/112116 |
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