Idiopathic AA amyloidosis presenting with initial abdominal pain: a case report and literature review
Amyloidosis is a rare disease, often secondary to chronic inflammation or autoimmune disorders, with an unclear etiology in some cases. Herein, we report a 67-year-old male patient presenting with recurrent abdominal pain and multi-system involvement. The diagnosis of AA amyloidosis was confirmed by...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1640436/full |
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| author | Pianpian Xia Pianpian Xia Pianpian Xia Deliang Liu Deliang Liu Deliang Liu Feihong Deng Feihong Deng Feihong Deng Dalian Ou Dalian Ou Dalian Ou Mingyang Deng |
| author_facet | Pianpian Xia Pianpian Xia Pianpian Xia Deliang Liu Deliang Liu Deliang Liu Feihong Deng Feihong Deng Feihong Deng Dalian Ou Dalian Ou Dalian Ou Mingyang Deng |
| author_sort | Pianpian Xia |
| collection | DOAJ |
| description | Amyloidosis is a rare disease, often secondary to chronic inflammation or autoimmune disorders, with an unclear etiology in some cases. Herein, we report a 67-year-old male patient presenting with recurrent abdominal pain and multi-system involvement. The diagnosis of AA amyloidosis was confirmed by Congo red staining of small intestinal mucosal and bone marrow biopsies. Despite comprehensive screening, no definite etiology was identified. This case highlights that amyloidosis should be considered in patients with unexplained abdominal pain and multisystem abnormalities, and early tissue biopsy is crucial for diagnosis. |
| format | Article |
| id | doaj-art-e9144d8ed3d24d59ad61be69187dfaf3 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-e9144d8ed3d24d59ad61be69187dfaf32025-08-20T04:02:51ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-08-011210.3389/fmed.2025.16404361640436Idiopathic AA amyloidosis presenting with initial abdominal pain: a case report and literature reviewPianpian Xia0Pianpian Xia1Pianpian Xia2Deliang Liu3Deliang Liu4Deliang Liu5Feihong Deng6Feihong Deng7Feihong Deng8Dalian Ou9Dalian Ou10Dalian Ou11Mingyang Deng12Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Center of Digestive Diseases, Central South University, Changsha, ChinaClinical Research Center for Digestive Diseases in Hunan Province, Changsha, ChinaDepartment of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Center of Digestive Diseases, Central South University, Changsha, ChinaClinical Research Center for Digestive Diseases in Hunan Province, Changsha, ChinaDepartment of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Center of Digestive Diseases, Central South University, Changsha, ChinaClinical Research Center for Digestive Diseases in Hunan Province, Changsha, ChinaDepartment of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Center of Digestive Diseases, Central South University, Changsha, ChinaClinical Research Center for Digestive Diseases in Hunan Province, Changsha, ChinaDepartment of Hematology, The Second Xiangya Hospital of Central South University, Changsha, ChinaAmyloidosis is a rare disease, often secondary to chronic inflammation or autoimmune disorders, with an unclear etiology in some cases. Herein, we report a 67-year-old male patient presenting with recurrent abdominal pain and multi-system involvement. The diagnosis of AA amyloidosis was confirmed by Congo red staining of small intestinal mucosal and bone marrow biopsies. Despite comprehensive screening, no definite etiology was identified. This case highlights that amyloidosis should be considered in patients with unexplained abdominal pain and multisystem abnormalities, and early tissue biopsy is crucial for diagnosis.https://www.frontiersin.org/articles/10.3389/fmed.2025.1640436/fullabdominal painAA amyloidosisdiagnosisetiologyserum amyloid A proteingastrointestinal diseases |
| spellingShingle | Pianpian Xia Pianpian Xia Pianpian Xia Deliang Liu Deliang Liu Deliang Liu Feihong Deng Feihong Deng Feihong Deng Dalian Ou Dalian Ou Dalian Ou Mingyang Deng Idiopathic AA amyloidosis presenting with initial abdominal pain: a case report and literature review Frontiers in Medicine abdominal pain AA amyloidosis diagnosis etiology serum amyloid A protein gastrointestinal diseases |
| title | Idiopathic AA amyloidosis presenting with initial abdominal pain: a case report and literature review |
| title_full | Idiopathic AA amyloidosis presenting with initial abdominal pain: a case report and literature review |
| title_fullStr | Idiopathic AA amyloidosis presenting with initial abdominal pain: a case report and literature review |
| title_full_unstemmed | Idiopathic AA amyloidosis presenting with initial abdominal pain: a case report and literature review |
| title_short | Idiopathic AA amyloidosis presenting with initial abdominal pain: a case report and literature review |
| title_sort | idiopathic aa amyloidosis presenting with initial abdominal pain a case report and literature review |
| topic | abdominal pain AA amyloidosis diagnosis etiology serum amyloid A protein gastrointestinal diseases |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1640436/full |
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