Early transcriptional responses reveal cell type-specific vulnerability and neuroprotective mechanisms in the neonatal ischemic hippocampus

Early transcriptional responses reveal cell type-specific vulnerability and neuroprotective mechanisms in the neonatal ischemic hippocampus

Abstract Neonatal hypoxic-ischemic (H-I) brain injury, a leading cause of neurodevelopmental disabilities, severely affects the metabolically active and neurogenic hippocampus. To investigate its acute effects and identify drug targets for early therapeutic windows, we applied single-nucleus RNA seq...

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Bibliographic Details
Main Authors: Aleksandr Ianevski, María Cámara-Quílez, Wei Wang, Rajikala Suganthan, Gunn Hildrestrand, Jonas Viken Grini, Dagny Sanden Døskeland, Jing Ye, Magnar Bjørås
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Acta Neuropathologica Communications
Subjects:
Neonatal hypoxia ischemia
Single-cell RNA sequencing
Hippocampal cell atlas
Machine learning
Neural vulnerability
Gene regulatory network
Online Access:https://doi.org/10.1186/s40478-025-02062-4
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https://doi.org/10.1186/s40478-025-02062-4

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