WEST SYNDROME REVISITED
West syndrome is an epileptic syndrome, characterized by a triad of symptoms: infantile spasms, hypsarrhythmia on interictal EEG, and a regression or delay of psycho-motoric development. According to the current concept, two of these three criteria suffice for the diagnosis. The incidence of this sy...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2017-08-01
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| Series: | Эпилепсия и пароксизмальные состояния |
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| Online Access: | https://www.epilepsia.su/jour/article/view/348 |
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| author | T. G. Okhapkina Z. K. Gorchanova I. V. Shulyakova E. S. Ilyina E. S. Michurina E. D. Belousova |
| author_facet | T. G. Okhapkina Z. K. Gorchanova I. V. Shulyakova E. S. Ilyina E. S. Michurina E. D. Belousova |
| author_sort | T. G. Okhapkina |
| collection | DOAJ |
| description | West syndrome is an epileptic syndrome, characterized by a triad of symptoms: infantile spasms, hypsarrhythmia on interictal EEG, and a regression or delay of psycho-motoric development. According to the current concept, two of these three criteria suffice for the diagnosis. The incidence of this syndrome is 1 per 2000 newborns. This article reviews recent publications on the etiology, pathogenesis, clinical course, diagnosis, and treatment options in West syndrome. The text is supplemented with illustrations of ictal EEG at infantile spasms and variants of hypsarrhythmia. Today, in addition to classical hypsarrhythmia, five versions of modified hypsarrhythmia are proposed: synchronized version, asymmetric version, version with stable focus of spikes or acute waves, version with rhythmic flattening episodes, version with high-amplitude and asynchronous slow activity. The hormonal therapy is recommended to begin the treatment; if not effective, vigabatrin is to be used as the second choice medication. |
| format | Article |
| id | doaj-art-e90e6c7cc3294517bbf9f228ddfe6fe1 |
| institution | Kabale University |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| publishDate | 2017-08-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj-art-e90e6c7cc3294517bbf9f228ddfe6fe12025-08-20T03:57:32ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882017-08-0192749010.17749/2077-8333.2017.9.2.074-090339WEST SYNDROME REVISITEDT. G. Okhapkina0Z. K. Gorchanova1I. V. Shulyakova2E. S. Ilyina3E. S. Michurina4E. D. Belousova5Russian National Research Medical University named after N.I. Pirogov, Health Ministry of Russian FederationRussian Children’s Clinical Hospital, Health Ministry of Russian FederationRussian Children’s Clinical Hospital, Health Ministry of Russian FederationRussian Children’s Clinical Hospital, Health Ministry of Russian FederationRussian Children’s Clinical Hospital, Health Ministry of Russian FederationRussian National Research Medical University named after N.I. Pirogov, Health Ministry of Russian FederationWest syndrome is an epileptic syndrome, characterized by a triad of symptoms: infantile spasms, hypsarrhythmia on interictal EEG, and a regression or delay of psycho-motoric development. According to the current concept, two of these three criteria suffice for the diagnosis. The incidence of this syndrome is 1 per 2000 newborns. This article reviews recent publications on the etiology, pathogenesis, clinical course, diagnosis, and treatment options in West syndrome. The text is supplemented with illustrations of ictal EEG at infantile spasms and variants of hypsarrhythmia. Today, in addition to classical hypsarrhythmia, five versions of modified hypsarrhythmia are proposed: synchronized version, asymmetric version, version with stable focus of spikes or acute waves, version with rhythmic flattening episodes, version with high-amplitude and asynchronous slow activity. The hormonal therapy is recommended to begin the treatment; if not effective, vigabatrin is to be used as the second choice medication.https://www.epilepsia.su/jour/article/view/348epilepsywest syndromeinfantile spasmsictal eeginterictal eegmodified hypsarrhythmiatreatment. |
| spellingShingle | T. G. Okhapkina Z. K. Gorchanova I. V. Shulyakova E. S. Ilyina E. S. Michurina E. D. Belousova WEST SYNDROME REVISITED Эпилепсия и пароксизмальные состояния epilepsy west syndrome infantile spasms ictal eeg interictal eeg modified hypsarrhythmia treatment. |
| title | WEST SYNDROME REVISITED |
| title_full | WEST SYNDROME REVISITED |
| title_fullStr | WEST SYNDROME REVISITED |
| title_full_unstemmed | WEST SYNDROME REVISITED |
| title_short | WEST SYNDROME REVISITED |
| title_sort | west syndrome revisited |
| topic | epilepsy west syndrome infantile spasms ictal eeg interictal eeg modified hypsarrhythmia treatment. |
| url | https://www.epilepsia.su/jour/article/view/348 |
| work_keys_str_mv | AT tgokhapkina westsyndromerevisited AT zkgorchanova westsyndromerevisited AT ivshulyakova westsyndromerevisited AT esilyina westsyndromerevisited AT esmichurina westsyndromerevisited AT edbelousova westsyndromerevisited |