Effect of polymorphism on IL1A to cancer susceptibility: Evidence based on 34,016 subjects
IL-1α is closely related to the development and metastasis of cancer, and its polymorphisms have been reported affecting the susceptibility of malignancy tumors, yet the conclusions are controversial. Present an overall meta-analysis was performed to reach more general findings. Relevant literature...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-12-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2019.1646750 |
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| author | Haoran Xia Yiding Chen Jialin Meng Chaozhao Liang |
| author_facet | Haoran Xia Yiding Chen Jialin Meng Chaozhao Liang |
| author_sort | Haoran Xia |
| collection | DOAJ |
| description | IL-1α is closely related to the development and metastasis of cancer, and its polymorphisms have been reported affecting the susceptibility of malignancy tumors, yet the conclusions are controversial. Present an overall meta-analysis was performed to reach more general findings. Relevant literature was searched from Google Scholar, Web of Science, PubMed, EMBASE, CNKI database and Wanfang database, and the association among polymorphism and cancer risk was appraised by counting ORs and 95% CIs of overall and stratification analysis. The date from 15,586 cases and 18,430 controls in 40 publications were enrolled. There is significantly upregulated risk leads by rs3783553 in all genetic models, while the same tendency was found in all cancer types. The results also suggest a high risk of cancer susceptibility in patients carried rs1800587 polymorphism, of which draw out form allelic and homozygote models in overall studies, especially for cervical cancer. However, there are no significant results in analysis of rs17561. In a word, IL1A SNPs play an essential role in upregulating cancer susceptibility, and current analysis provides detail date for further study in the future. |
| format | Article |
| id | doaj-art-e90ddadb40144f4ca5748e62b47ee3fb |
| institution | Kabale University |
| issn | 2169-1401 2169-141X |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj-art-e90ddadb40144f4ca5748e62b47ee3fb2025-08-20T03:51:19ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2019-12-014713138315210.1080/21691401.2019.1646750Effect of polymorphism on IL1A to cancer susceptibility: Evidence based on 34,016 subjectsHaoran Xia0Yiding Chen1Jialin Meng2Chaozhao Liang3Department of Urology, the First Affiliated Hospital of Anhui Medical University; Institute of Urology and Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, Anhui, ChinaThe First Clinical College of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Urology, the First Affiliated Hospital of Anhui Medical University; Institute of Urology and Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Urology, the First Affiliated Hospital of Anhui Medical University; Institute of Urology and Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, Anhui, ChinaIL-1α is closely related to the development and metastasis of cancer, and its polymorphisms have been reported affecting the susceptibility of malignancy tumors, yet the conclusions are controversial. Present an overall meta-analysis was performed to reach more general findings. Relevant literature was searched from Google Scholar, Web of Science, PubMed, EMBASE, CNKI database and Wanfang database, and the association among polymorphism and cancer risk was appraised by counting ORs and 95% CIs of overall and stratification analysis. The date from 15,586 cases and 18,430 controls in 40 publications were enrolled. There is significantly upregulated risk leads by rs3783553 in all genetic models, while the same tendency was found in all cancer types. The results also suggest a high risk of cancer susceptibility in patients carried rs1800587 polymorphism, of which draw out form allelic and homozygote models in overall studies, especially for cervical cancer. However, there are no significant results in analysis of rs17561. In a word, IL1A SNPs play an essential role in upregulating cancer susceptibility, and current analysis provides detail date for further study in the future.https://www.tandfonline.com/doi/10.1080/21691401.2019.1646750IL1Acancer riskmeta-analysisgene polymorphismrs1800587rs3783553 |
| spellingShingle | Haoran Xia Yiding Chen Jialin Meng Chaozhao Liang Effect of polymorphism on IL1A to cancer susceptibility: Evidence based on 34,016 subjects Artificial Cells, Nanomedicine, and Biotechnology IL1A cancer risk meta-analysis gene polymorphism rs1800587 rs3783553 |
| title | Effect of polymorphism on IL1A to cancer susceptibility: Evidence based on 34,016 subjects |
| title_full | Effect of polymorphism on IL1A to cancer susceptibility: Evidence based on 34,016 subjects |
| title_fullStr | Effect of polymorphism on IL1A to cancer susceptibility: Evidence based on 34,016 subjects |
| title_full_unstemmed | Effect of polymorphism on IL1A to cancer susceptibility: Evidence based on 34,016 subjects |
| title_short | Effect of polymorphism on IL1A to cancer susceptibility: Evidence based on 34,016 subjects |
| title_sort | effect of polymorphism on il1a to cancer susceptibility evidence based on 34 016 subjects |
| topic | IL1A cancer risk meta-analysis gene polymorphism rs1800587 rs3783553 |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2019.1646750 |
| work_keys_str_mv | AT haoranxia effectofpolymorphismonil1atocancersusceptibilityevidencebasedon34016subjects AT yidingchen effectofpolymorphismonil1atocancersusceptibilityevidencebasedon34016subjects AT jialinmeng effectofpolymorphismonil1atocancersusceptibilityevidencebasedon34016subjects AT chaozhaoliang effectofpolymorphismonil1atocancersusceptibilityevidencebasedon34016subjects |