PERSPECTIVES OF ANTISENSE GENE THERAPY IN ORGAN TRANSPLANTATION
Global organ shortage is the crucial point of transplantation nowadays. Usage of expanded criteria donors represents reliable source of donor organs, making transplantation more accessible for patients with end stage organs failure. Ischemia-reperfusion injury followed by the activation of programme...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2013-03-01
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| Series: | Вестник трансплантологии и искусственных органов |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/147 |
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| author | O. N. Reznik A. E. Skvortsov D. O. Kuzmin A. P. Tutin A. O. Reznik |
| author_facet | O. N. Reznik A. E. Skvortsov D. O. Kuzmin A. P. Tutin A. O. Reznik |
| author_sort | O. N. Reznik |
| collection | DOAJ |
| description | Global organ shortage is the crucial point of transplantation nowadays. Usage of expanded criteria donors represents reliable source of donor organs, making transplantation more accessible for patients with end stage organs failure. Ischemia-reperfusion injury followed by the activation of programmed cell death scenarios remains the main obstacle in utilization of marginal grafts. Programmed cell death often leads to life threatening complications in posttransplant period. Antisense gene therapy could provide a therapeutic tool, capable to improve quality of grafts and, consequently, transplantation outcomes. |
| format | Article |
| id | doaj-art-e90c2f981b7c48dea12cc796729661cf |
| institution | DOAJ |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2013-03-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-e90c2f981b7c48dea12cc796729661cf2025-08-20T03:21:06ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912013-03-0115110611710.15825/1995-1191-2013-1-106-11790PERSPECTIVES OF ANTISENSE GENE THERAPY IN ORGAN TRANSPLANTATIONO. N. Reznik0A. E. Skvortsov1D. O. Kuzmin2A. P. Tutin3A. O. Reznik4St. Petersburg State Medical University named after Academician I.P. PavlovSt. Petersburg State Medical University named after Academician I.P. PavlovSt. Petersburg State Medical University named after Academician I.P. PavlovSt. Petersburg State Medical University named after Academician I.P. PavlovSt. Petersburg State Medical University named after Academician I.P. PavlovGlobal organ shortage is the crucial point of transplantation nowadays. Usage of expanded criteria donors represents reliable source of donor organs, making transplantation more accessible for patients with end stage organs failure. Ischemia-reperfusion injury followed by the activation of programmed cell death scenarios remains the main obstacle in utilization of marginal grafts. Programmed cell death often leads to life threatening complications in posttransplant period. Antisense gene therapy could provide a therapeutic tool, capable to improve quality of grafts and, consequently, transplantation outcomes.https://journal.transpl.ru/vtio/article/view/147antisense gene therapyorgan transplantation |
| spellingShingle | O. N. Reznik A. E. Skvortsov D. O. Kuzmin A. P. Tutin A. O. Reznik PERSPECTIVES OF ANTISENSE GENE THERAPY IN ORGAN TRANSPLANTATION Вестник трансплантологии и искусственных органов antisense gene therapy organ transplantation |
| title | PERSPECTIVES OF ANTISENSE GENE THERAPY IN ORGAN TRANSPLANTATION |
| title_full | PERSPECTIVES OF ANTISENSE GENE THERAPY IN ORGAN TRANSPLANTATION |
| title_fullStr | PERSPECTIVES OF ANTISENSE GENE THERAPY IN ORGAN TRANSPLANTATION |
| title_full_unstemmed | PERSPECTIVES OF ANTISENSE GENE THERAPY IN ORGAN TRANSPLANTATION |
| title_short | PERSPECTIVES OF ANTISENSE GENE THERAPY IN ORGAN TRANSPLANTATION |
| title_sort | perspectives of antisense gene therapy in organ transplantation |
| topic | antisense gene therapy organ transplantation |
| url | https://journal.transpl.ru/vtio/article/view/147 |
| work_keys_str_mv | AT onreznik perspectivesofantisensegenetherapyinorgantransplantation AT aeskvortsov perspectivesofantisensegenetherapyinorgantransplantation AT dokuzmin perspectivesofantisensegenetherapyinorgantransplantation AT aptutin perspectivesofantisensegenetherapyinorgantransplantation AT aoreznik perspectivesofantisensegenetherapyinorgantransplantation |