Validating At-Home Urinary Hormone Measurements in Postpartum and Perimenopause Fertility Transitions
Background: Measuring quantitative menstrual cycle hormones at home may help women better understand their postpartum and perimenopause fertility transitions, but these quantitative fertility monitors require validation. Materials and Methods: This study included 16 North American women, aged 28–51,...
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Mary Ann Liebert
2025-01-01
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| Series: | Women's Health Reports |
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| Online Access: | https://www.liebertpub.com/doi/10.1089/whr.2024.0157 |
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| author | Thomas P. Bouchard Patricia K. Doyle-Baker Paul J. Yong Richard Fehring Mary Schneider |
| author_facet | Thomas P. Bouchard Patricia K. Doyle-Baker Paul J. Yong Richard Fehring Mary Schneider |
| author_sort | Thomas P. Bouchard |
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| description | Background: Measuring quantitative menstrual cycle hormones at home may help women better understand their postpartum and perimenopause fertility transitions, but these quantitative fertility monitors require validation. Materials and Methods: This study included 16 North American women, aged 28–51, during either the postpartum (n = 8, cycles = 18) or perimenopause (n = 8, cycles = 35) fertility transitions testing daily first-morning urine testing with both the Mira Monitor and ClearBlue Fertility Monitor (CBFM) along with menstrual cycle parameter tracking. The main outcome measures were a rise in estrone-3-glucuronide (E13G) and luteinizing hormone (LH) urine hormone values from the Mira monitor correlated to low, high, or peak values on the CBFM. Results: Both in the postpartum and perimenopause transitions, the identification of the day of ovulation based on the LH surge on the Mira and CBFM monitors was highly correlated (R = 0.94 and 0.83, p < 0.001). The E13G levels on the Mira monitor were significantly higher for a CBFM reading of “High” compared with “Low” for both the postpartum and perimenopausal cycles (all p < 0.001). Similarly, the LH levels on the Mira monitor were significantly higher for a CBFM reading of “Peak” (LH surge) compared with “High” for both the postpartum and perimenopausal cycles (all p < 0.001). Conclusions: The LH surge and levels of E13G in urine identified on the quantitative Mira fertility monitor strongly correlate to the LH surge and the shift from low to high on the CBFM during the postpartum and perimenopause transitions. |
| format | Article |
| id | doaj-art-e90b49d7606a465d951df737a607d9c7 |
| institution | OA Journals |
| issn | 2688-4844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Mary Ann Liebert |
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| series | Women's Health Reports |
| spelling | doaj-art-e90b49d7606a465d951df737a607d9c72025-08-20T02:30:49ZengMary Ann LiebertWomen's Health Reports2688-48442025-01-016136937610.1089/whr.2024.0157Validating At-Home Urinary Hormone Measurements in Postpartum and Perimenopause Fertility TransitionsThomas P. Bouchard0Patricia K. Doyle-Baker1Paul J. Yong2Richard Fehring3Mary Schneider4Department of Family Medicine, University of Calgary, Calgary, Canada.Faculty of Kinesiology, University of Calgary, Calgary, Canada.Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada.College of Nursing, Marquette University, Milwaukee, Wisconsin, USA.College of Nursing, Marquette University, Milwaukee, Wisconsin, USA.Background: Measuring quantitative menstrual cycle hormones at home may help women better understand their postpartum and perimenopause fertility transitions, but these quantitative fertility monitors require validation. Materials and Methods: This study included 16 North American women, aged 28–51, during either the postpartum (n = 8, cycles = 18) or perimenopause (n = 8, cycles = 35) fertility transitions testing daily first-morning urine testing with both the Mira Monitor and ClearBlue Fertility Monitor (CBFM) along with menstrual cycle parameter tracking. The main outcome measures were a rise in estrone-3-glucuronide (E13G) and luteinizing hormone (LH) urine hormone values from the Mira monitor correlated to low, high, or peak values on the CBFM. Results: Both in the postpartum and perimenopause transitions, the identification of the day of ovulation based on the LH surge on the Mira and CBFM monitors was highly correlated (R = 0.94 and 0.83, p < 0.001). The E13G levels on the Mira monitor were significantly higher for a CBFM reading of “High” compared with “Low” for both the postpartum and perimenopausal cycles (all p < 0.001). Similarly, the LH levels on the Mira monitor were significantly higher for a CBFM reading of “Peak” (LH surge) compared with “High” for both the postpartum and perimenopausal cycles (all p < 0.001). Conclusions: The LH surge and levels of E13G in urine identified on the quantitative Mira fertility monitor strongly correlate to the LH surge and the shift from low to high on the CBFM during the postpartum and perimenopause transitions.https://www.liebertpub.com/doi/10.1089/whr.2024.0157ovulationmenstrual cycleperimenopausepostpartumestrone-3-glucuronide (E13G)luteinizing hormone (LH) |
| spellingShingle | Thomas P. Bouchard Patricia K. Doyle-Baker Paul J. Yong Richard Fehring Mary Schneider Validating At-Home Urinary Hormone Measurements in Postpartum and Perimenopause Fertility Transitions Women's Health Reports ovulation menstrual cycle perimenopause postpartum estrone-3-glucuronide (E13G) luteinizing hormone (LH) |
| title | Validating At-Home Urinary Hormone Measurements in Postpartum and Perimenopause Fertility Transitions |
| title_full | Validating At-Home Urinary Hormone Measurements in Postpartum and Perimenopause Fertility Transitions |
| title_fullStr | Validating At-Home Urinary Hormone Measurements in Postpartum and Perimenopause Fertility Transitions |
| title_full_unstemmed | Validating At-Home Urinary Hormone Measurements in Postpartum and Perimenopause Fertility Transitions |
| title_short | Validating At-Home Urinary Hormone Measurements in Postpartum and Perimenopause Fertility Transitions |
| title_sort | validating at home urinary hormone measurements in postpartum and perimenopause fertility transitions |
| topic | ovulation menstrual cycle perimenopause postpartum estrone-3-glucuronide (E13G) luteinizing hormone (LH) |
| url | https://www.liebertpub.com/doi/10.1089/whr.2024.0157 |
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