Assessment of single-vessel cerebral blood velocity by phase contrast fMRI.
Current approaches to high-field functional MRI (fMRI) provide 2 means to map hemodynamics at the level of single vessels in the brain. One is through changes in deoxyhemoglobin in venules, i.e., blood oxygenation level-dependent (BOLD) fMRI, while the second is through changes in arteriole diameter...
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| Format: | Article |
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Public Library of Science (PLoS)
2021-09-01
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| Series: | PLoS Biology |
| Online Access: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000923&type=printable |
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| author | Xuming Chen Yuanyuan Jiang Sangcheon Choi Rolf Pohmann Klaus Scheffler David Kleinfeld Xin Yu Xin Yu |
| author_facet | Xuming Chen Yuanyuan Jiang Sangcheon Choi Rolf Pohmann Klaus Scheffler David Kleinfeld Xin Yu Xin Yu |
| author_sort | Xuming Chen |
| collection | DOAJ |
| description | Current approaches to high-field functional MRI (fMRI) provide 2 means to map hemodynamics at the level of single vessels in the brain. One is through changes in deoxyhemoglobin in venules, i.e., blood oxygenation level-dependent (BOLD) fMRI, while the second is through changes in arteriole diameter, i.e., cerebral blood volume (CBV) fMRI. Here, we introduce cerebral blood flow-related velocity-based fMRI, denoted CBFv-fMRI, which uses high-resolution phase contrast (PC) MRI to form velocity measurements of flow. We use CBFv-fMRI in measure changes in blood velocity in single penetrating microvessels across rat parietal cortex. In contrast to the venule-dominated BOLD and arteriole-dominated CBV fMRI signals, CBFv-fMRI is comparable from both arterioles and venules. A single fMRI platform is used to map changes in blood pO2 (BOLD), volume (CBV), and velocity (CBFv). This combined high-resolution single-vessel fMRI mapping scheme enables vessel-specific hemodynamic mapping in animal models of normal and diseased states and further has translational potential to map vascular dementia in diseased or injured human brains with ultra-high-field fMRI. |
| format | Article |
| id | doaj-art-e90b0ffc45fc4710b609327a2014466a |
| institution | DOAJ |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-e90b0ffc45fc4710b609327a2014466a2025-08-20T02:55:20ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852021-09-01199e300092310.1371/journal.pbio.3000923Assessment of single-vessel cerebral blood velocity by phase contrast fMRI.Xuming ChenYuanyuan JiangSangcheon ChoiRolf PohmannKlaus SchefflerDavid KleinfeldXin YuXin YuCurrent approaches to high-field functional MRI (fMRI) provide 2 means to map hemodynamics at the level of single vessels in the brain. One is through changes in deoxyhemoglobin in venules, i.e., blood oxygenation level-dependent (BOLD) fMRI, while the second is through changes in arteriole diameter, i.e., cerebral blood volume (CBV) fMRI. Here, we introduce cerebral blood flow-related velocity-based fMRI, denoted CBFv-fMRI, which uses high-resolution phase contrast (PC) MRI to form velocity measurements of flow. We use CBFv-fMRI in measure changes in blood velocity in single penetrating microvessels across rat parietal cortex. In contrast to the venule-dominated BOLD and arteriole-dominated CBV fMRI signals, CBFv-fMRI is comparable from both arterioles and venules. A single fMRI platform is used to map changes in blood pO2 (BOLD), volume (CBV), and velocity (CBFv). This combined high-resolution single-vessel fMRI mapping scheme enables vessel-specific hemodynamic mapping in animal models of normal and diseased states and further has translational potential to map vascular dementia in diseased or injured human brains with ultra-high-field fMRI.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000923&type=printable |
| spellingShingle | Xuming Chen Yuanyuan Jiang Sangcheon Choi Rolf Pohmann Klaus Scheffler David Kleinfeld Xin Yu Xin Yu Assessment of single-vessel cerebral blood velocity by phase contrast fMRI. PLoS Biology |
| title | Assessment of single-vessel cerebral blood velocity by phase contrast fMRI. |
| title_full | Assessment of single-vessel cerebral blood velocity by phase contrast fMRI. |
| title_fullStr | Assessment of single-vessel cerebral blood velocity by phase contrast fMRI. |
| title_full_unstemmed | Assessment of single-vessel cerebral blood velocity by phase contrast fMRI. |
| title_short | Assessment of single-vessel cerebral blood velocity by phase contrast fMRI. |
| title_sort | assessment of single vessel cerebral blood velocity by phase contrast fmri |
| url | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000923&type=printable |
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