Relationship of monocyte to high-density lipoprotein ratio (MHR) and other inflammatory biomarkers with sarcopenia: a population-based study
Abstract Objectives In previous studies, several inflammatory biomarkers derived from complete blood cell counts (CBC), such as systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and non‑high‑density lipoprotein cholesterol to high‑density lipoprotein cholesterol ratio (...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-025-02464-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861686340157440 |
|---|---|
| author | Zhiwei Xue Jian Cao Jianhui Mou Rui Wang Peng Liu |
| author_facet | Zhiwei Xue Jian Cao Jianhui Mou Rui Wang Peng Liu |
| author_sort | Zhiwei Xue |
| collection | DOAJ |
| description | Abstract Objectives In previous studies, several inflammatory biomarkers derived from complete blood cell counts (CBC), such as systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and non‑high‑density lipoprotein cholesterol to high‑density lipoprotein cholesterol ratio (NHHR) have been identified as predictors of sarcopenia. However, whether Monocyte to High-Density Lipoprotein Cholesterol Ratio (MHR) can predict the development of sarcopenia has not yet been established. The research first attempts to investigate the association between MHR and low muscle mass and to compare the predictive abilities of MHR, SII, NLR, and NHHR for low muscle mass risk. Methods The study comprised 10,321 participants aged 20 years and above from the United States. Multiple logistic regression was performed to explore the association between ln-transformed MHR, SII, NLR, NHHR and low muscle mass. Additionally, AUC values and ROC curves were used to assess the predictive effectiveness of ln MHR and other markers (ln SII, ln NLR, ln NHHR, ln MHR + ln SII, ln MHR + ln NHHR, and ln MHR + ln NLR). The bootstrap estimated 95% Cl was shown with the AUC. Results In the fully adjusted model, ln SII, ln NLR, ln NHHR, ln MHR, ln MHR + ln SII, ln MHR + ln NHHR, and ln MHR + ln NLR were positively associated with low muscle mass (ln SII: OR = 1.59 [1.37–1.84]; ln NLR: OR = 1.35 [1.13–1.60]; ln NHHR: OR = 1.49[1.27–1.75]; ln MHR: OR = 1.98 [1.68–2.33]; ln MHR + ln SII: OR = 1.61 [1.46–1.79]; ln MHR + ln NHHR: OR = 1.42 [1.29–1.56]; ln MHR + ln NLR: OR = 1.58 [1.41–1.78]). Compared to the lowest quartile of ln MHR, higher quartiles were significantly associated with increased odds of low muscle mass (P for trend < 0.0001). In ROC analysis, ln MHR + ln SII had a higher AUC value than other indicators (AUC = 0.608). Conclusion Ln-transformed MHR, SII, NLR, and NHHR were positively associated with low muscle mass. MHR outperforms SII, NLR, and NHHR in predicting sarcopenia. |
| format | Article |
| id | doaj-art-e90a012c534d4515b89d940f6db2ceb6 |
| institution | Kabale University |
| issn | 1476-511X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj-art-e90a012c534d4515b89d940f6db2ceb62025-02-09T12:52:39ZengBMCLipids in Health and Disease1476-511X2025-02-012411910.1186/s12944-025-02464-2Relationship of monocyte to high-density lipoprotein ratio (MHR) and other inflammatory biomarkers with sarcopenia: a population-based studyZhiwei Xue0Jian Cao1Jianhui Mou2Rui Wang3Peng Liu4Department of Orthopaedigs, China-Japan Union Hospital of Jilin UniversityDepartment of Orthopaedigs, China-Japan Union Hospital of Jilin UniversityDepartment of Orthopaedigs, China-Japan Union Hospital of Jilin UniversityDepartment of Orthopaedigs, China-Japan Union Hospital of Jilin UniversityDepartment of Orthopaedigs, China-Japan Union Hospital of Jilin UniversityAbstract Objectives In previous studies, several inflammatory biomarkers derived from complete blood cell counts (CBC), such as systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and non‑high‑density lipoprotein cholesterol to high‑density lipoprotein cholesterol ratio (NHHR) have been identified as predictors of sarcopenia. However, whether Monocyte to High-Density Lipoprotein Cholesterol Ratio (MHR) can predict the development of sarcopenia has not yet been established. The research first attempts to investigate the association between MHR and low muscle mass and to compare the predictive abilities of MHR, SII, NLR, and NHHR for low muscle mass risk. Methods The study comprised 10,321 participants aged 20 years and above from the United States. Multiple logistic regression was performed to explore the association between ln-transformed MHR, SII, NLR, NHHR and low muscle mass. Additionally, AUC values and ROC curves were used to assess the predictive effectiveness of ln MHR and other markers (ln SII, ln NLR, ln NHHR, ln MHR + ln SII, ln MHR + ln NHHR, and ln MHR + ln NLR). The bootstrap estimated 95% Cl was shown with the AUC. Results In the fully adjusted model, ln SII, ln NLR, ln NHHR, ln MHR, ln MHR + ln SII, ln MHR + ln NHHR, and ln MHR + ln NLR were positively associated with low muscle mass (ln SII: OR = 1.59 [1.37–1.84]; ln NLR: OR = 1.35 [1.13–1.60]; ln NHHR: OR = 1.49[1.27–1.75]; ln MHR: OR = 1.98 [1.68–2.33]; ln MHR + ln SII: OR = 1.61 [1.46–1.79]; ln MHR + ln NHHR: OR = 1.42 [1.29–1.56]; ln MHR + ln NLR: OR = 1.58 [1.41–1.78]). Compared to the lowest quartile of ln MHR, higher quartiles were significantly associated with increased odds of low muscle mass (P for trend < 0.0001). In ROC analysis, ln MHR + ln SII had a higher AUC value than other indicators (AUC = 0.608). Conclusion Ln-transformed MHR, SII, NLR, and NHHR were positively associated with low muscle mass. MHR outperforms SII, NLR, and NHHR in predicting sarcopenia.https://doi.org/10.1186/s12944-025-02464-2Monocyte to high-density lipoprotein cholesterol ratioSarcopeniaLow muscle massNHANES |
| spellingShingle | Zhiwei Xue Jian Cao Jianhui Mou Rui Wang Peng Liu Relationship of monocyte to high-density lipoprotein ratio (MHR) and other inflammatory biomarkers with sarcopenia: a population-based study Lipids in Health and Disease Monocyte to high-density lipoprotein cholesterol ratio Sarcopenia Low muscle mass NHANES |
| title | Relationship of monocyte to high-density lipoprotein ratio (MHR) and other inflammatory biomarkers with sarcopenia: a population-based study |
| title_full | Relationship of monocyte to high-density lipoprotein ratio (MHR) and other inflammatory biomarkers with sarcopenia: a population-based study |
| title_fullStr | Relationship of monocyte to high-density lipoprotein ratio (MHR) and other inflammatory biomarkers with sarcopenia: a population-based study |
| title_full_unstemmed | Relationship of monocyte to high-density lipoprotein ratio (MHR) and other inflammatory biomarkers with sarcopenia: a population-based study |
| title_short | Relationship of monocyte to high-density lipoprotein ratio (MHR) and other inflammatory biomarkers with sarcopenia: a population-based study |
| title_sort | relationship of monocyte to high density lipoprotein ratio mhr and other inflammatory biomarkers with sarcopenia a population based study |
| topic | Monocyte to high-density lipoprotein cholesterol ratio Sarcopenia Low muscle mass NHANES |
| url | https://doi.org/10.1186/s12944-025-02464-2 |
| work_keys_str_mv | AT zhiweixue relationshipofmonocytetohighdensitylipoproteinratiomhrandotherinflammatorybiomarkerswithsarcopeniaapopulationbasedstudy AT jiancao relationshipofmonocytetohighdensitylipoproteinratiomhrandotherinflammatorybiomarkerswithsarcopeniaapopulationbasedstudy AT jianhuimou relationshipofmonocytetohighdensitylipoproteinratiomhrandotherinflammatorybiomarkerswithsarcopeniaapopulationbasedstudy AT ruiwang relationshipofmonocytetohighdensitylipoproteinratiomhrandotherinflammatorybiomarkerswithsarcopeniaapopulationbasedstudy AT pengliu relationshipofmonocytetohighdensitylipoproteinratiomhrandotherinflammatorybiomarkerswithsarcopeniaapopulationbasedstudy |