Inflammatory mechanisms and intervention strategies for sepsis‐induced myocardial dysfunction
Abstract Sepsis‐induced myocardial dysfunction (SIMD) is the leading cause of death in patients with sepsis in the intensive care units. The main manifestations of SIMD are systolic and diastolic dysfunctions of the myocardium. Despite our initial understanding of the SIMD over the past three decade...
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.860 |
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| author | Yuxin Nong Xuebiao Wei Danqing Yu |
| author_facet | Yuxin Nong Xuebiao Wei Danqing Yu |
| author_sort | Yuxin Nong |
| collection | DOAJ |
| description | Abstract Sepsis‐induced myocardial dysfunction (SIMD) is the leading cause of death in patients with sepsis in the intensive care units. The main manifestations of SIMD are systolic and diastolic dysfunctions of the myocardium. Despite our initial understanding of the SIMD over the past three decades, the incidence and mortality of SIMD remain high. This may be attributed to the large degree of heterogeneity among the initiating factors, disease processes, and host states involved in SIMD. Previously, organ dysfunction caused by sepsis was thought to be an impairment brought about by an excessive inflammatory response. However, many recent studies have shown that SIMD is a consequence of a combination of factors shaped by the inflammatory responses between the pathogen and the host. In this article, we review the mechanisms of the inflammatory responses and potential novel therapeutic strategies in SIMD. |
| format | Article |
| id | doaj-art-e909c8e76cd24ffba0292fa5bd88be41 |
| institution | OA Journals |
| issn | 2050-4527 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-e909c8e76cd24ffba0292fa5bd88be412025-08-20T02:15:41ZengWileyImmunity, Inflammation and Disease2050-45272023-05-01115n/an/a10.1002/iid3.860Inflammatory mechanisms and intervention strategies for sepsis‐induced myocardial dysfunctionYuxin Nong0Xuebiao Wei1Danqing Yu2Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou ChinaDepartment of Geriatric Intensive Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou ChinaDepartment of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou ChinaAbstract Sepsis‐induced myocardial dysfunction (SIMD) is the leading cause of death in patients with sepsis in the intensive care units. The main manifestations of SIMD are systolic and diastolic dysfunctions of the myocardium. Despite our initial understanding of the SIMD over the past three decades, the incidence and mortality of SIMD remain high. This may be attributed to the large degree of heterogeneity among the initiating factors, disease processes, and host states involved in SIMD. Previously, organ dysfunction caused by sepsis was thought to be an impairment brought about by an excessive inflammatory response. However, many recent studies have shown that SIMD is a consequence of a combination of factors shaped by the inflammatory responses between the pathogen and the host. In this article, we review the mechanisms of the inflammatory responses and potential novel therapeutic strategies in SIMD.https://doi.org/10.1002/iid3.860host‐pathogen interactionsinflammationmyocardial dysfunctionsepsistargeted therapy |
| spellingShingle | Yuxin Nong Xuebiao Wei Danqing Yu Inflammatory mechanisms and intervention strategies for sepsis‐induced myocardial dysfunction Immunity, Inflammation and Disease host‐pathogen interactions inflammation myocardial dysfunction sepsis targeted therapy |
| title | Inflammatory mechanisms and intervention strategies for sepsis‐induced myocardial dysfunction |
| title_full | Inflammatory mechanisms and intervention strategies for sepsis‐induced myocardial dysfunction |
| title_fullStr | Inflammatory mechanisms and intervention strategies for sepsis‐induced myocardial dysfunction |
| title_full_unstemmed | Inflammatory mechanisms and intervention strategies for sepsis‐induced myocardial dysfunction |
| title_short | Inflammatory mechanisms and intervention strategies for sepsis‐induced myocardial dysfunction |
| title_sort | inflammatory mechanisms and intervention strategies for sepsis induced myocardial dysfunction |
| topic | host‐pathogen interactions inflammation myocardial dysfunction sepsis targeted therapy |
| url | https://doi.org/10.1002/iid3.860 |
| work_keys_str_mv | AT yuxinnong inflammatorymechanismsandinterventionstrategiesforsepsisinducedmyocardialdysfunction AT xuebiaowei inflammatorymechanismsandinterventionstrategiesforsepsisinducedmyocardialdysfunction AT danqingyu inflammatorymechanismsandinterventionstrategiesforsepsisinducedmyocardialdysfunction |