Targeting the ferroptosis pathway for rheumatoid arthritis: molecular mechanisms and prospects for inhibitor development

Targeting the ferroptosis pathway for rheumatoid arthritis: molecular mechanisms and prospects for inhibitor development

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease with severe complications. Ferroptosis, an iron-dependent form of apoptosis, encompasses mechanisms including iron overload, lipid peroxidation, redox homeostasis, and reactive oxygen species accumulation, all of which are closely re...

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Bibliographic Details
Main Authors: Zhuoling Wang, Xinyue Bai, Huahua Zhang, Min Yang, Meilin Liu, Tingyu Nie, Tianjiao Li, Mingru Zhang, Xingdan Wang, Jin Wang, Jiming Han, Xiaolong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
ferroptosis
rheumatoid arthritis
lipid peroxidation
natural medicine
nanomedicine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1610121/full
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