Targeting the ferroptosis pathway for rheumatoid arthritis: molecular mechanisms and prospects for inhibitor development
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease with severe complications. Ferroptosis, an iron-dependent form of apoptosis, encompasses mechanisms including iron overload, lipid peroxidation, redox homeostasis, and reactive oxygen species accumulation, all of which are closely re...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1610121/full |
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| author | Zhuoling Wang Xinyue Bai Huahua Zhang Min Yang Meilin Liu Tingyu Nie Tianjiao Li Mingru Zhang Xingdan Wang Jin Wang Jiming Han Xiaolong Liu |
| author_facet | Zhuoling Wang Xinyue Bai Huahua Zhang Min Yang Meilin Liu Tingyu Nie Tianjiao Li Mingru Zhang Xingdan Wang Jin Wang Jiming Han Xiaolong Liu |
| author_sort | Zhuoling Wang |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease with severe complications. Ferroptosis, an iron-dependent form of apoptosis, encompasses mechanisms including iron overload, lipid peroxidation, redox homeostasis, and reactive oxygen species accumulation, all of which are closely related to RA pathogenesis. This study focused on the mechanism of ferroptosis and RA, detailing their relationship and outlining the reported roles of ferroptosis inhibitors in RA treatment to provide a useful research basis in drug discovery and development and for clinicians. |
| format | Article |
| id | doaj-art-e9088e65d5ce4688b5f914ba1a2a17c3 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-e9088e65d5ce4688b5f914ba1a2a17c32025-08-20T02:08:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.16101211610121Targeting the ferroptosis pathway for rheumatoid arthritis: molecular mechanisms and prospects for inhibitor developmentZhuoling Wang0Xinyue Bai1Huahua Zhang2Min Yang3Meilin Liu4Tingyu Nie5Tianjiao Li6Mingru Zhang7Xingdan Wang8Jin Wang9Jiming Han10Xiaolong Liu11Medical Research and Experiment Center, Yan’an Medical College of Yan’an University, Yan’an, ChinaMedical Research and Experiment Center, Yan’an Medical College of Yan’an University, Yan’an, ChinaMedical Research and Experiment Center, Yan’an Medical College of Yan’an University, Yan’an, ChinaMedical Research and Experiment Center, Yan’an Medical College of Yan’an University, Yan’an, ChinaMedical Research and Experiment Center, Yan’an Medical College of Yan’an University, Yan’an, ChinaMedical Research and Experiment Center, Yan’an Medical College of Yan’an University, Yan’an, ChinaMedical Research and Experiment Center, Yan’an Medical College of Yan’an University, Yan’an, ChinaMedical Research and Experiment Center, Yan’an Medical College of Yan’an University, Yan’an, ChinaMedical Research and Experiment Center, Yan’an Medical College of Yan’an University, Yan’an, ChinaNursing Department of Yan’an University Affiliated Hospital, Yan’an, ChinaMedical Research and Experiment Center, Yan’an Medical College of Yan’an University, Yan’an, ChinaMedical Research and Experiment Center, Yan’an Medical College of Yan’an University, Yan’an, ChinaRheumatoid arthritis (RA) is a chronic systemic autoimmune disease with severe complications. Ferroptosis, an iron-dependent form of apoptosis, encompasses mechanisms including iron overload, lipid peroxidation, redox homeostasis, and reactive oxygen species accumulation, all of which are closely related to RA pathogenesis. This study focused on the mechanism of ferroptosis and RA, detailing their relationship and outlining the reported roles of ferroptosis inhibitors in RA treatment to provide a useful research basis in drug discovery and development and for clinicians.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1610121/fullferroptosisrheumatoid arthritislipid peroxidationnatural medicinenanomedicine |
| spellingShingle | Zhuoling Wang Xinyue Bai Huahua Zhang Min Yang Meilin Liu Tingyu Nie Tianjiao Li Mingru Zhang Xingdan Wang Jin Wang Jiming Han Xiaolong Liu Targeting the ferroptosis pathway for rheumatoid arthritis: molecular mechanisms and prospects for inhibitor development Frontiers in Immunology ferroptosis rheumatoid arthritis lipid peroxidation natural medicine nanomedicine |
| title | Targeting the ferroptosis pathway for rheumatoid arthritis: molecular mechanisms and prospects for inhibitor development |
| title_full | Targeting the ferroptosis pathway for rheumatoid arthritis: molecular mechanisms and prospects for inhibitor development |
| title_fullStr | Targeting the ferroptosis pathway for rheumatoid arthritis: molecular mechanisms and prospects for inhibitor development |
| title_full_unstemmed | Targeting the ferroptosis pathway for rheumatoid arthritis: molecular mechanisms and prospects for inhibitor development |
| title_short | Targeting the ferroptosis pathway for rheumatoid arthritis: molecular mechanisms and prospects for inhibitor development |
| title_sort | targeting the ferroptosis pathway for rheumatoid arthritis molecular mechanisms and prospects for inhibitor development |
| topic | ferroptosis rheumatoid arthritis lipid peroxidation natural medicine nanomedicine |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1610121/full |
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