FOXO3a/miR-4259-driven LDHA expression as a key mechanism of gemcitabine sensitivity in pancreatic ductal adenocarcinoma

FOXO3a/miR-4259-driven LDHA expression as a key mechanism of gemcitabine sensitivity in pancreatic ductal adenocarcinoma

Abstract Background Lactate dehydrogenase A (LDHA) can regulate tumorigenesis and cancer progression. Nevertheless, whether the regulation of LDHA is involved in the development of gemcitabine resistance in PDAC has not yet been fully elucidated. Increasing studies have shown that cancer acquired dr...

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Main Authors: Tung-Wei Hsu, Wan-Yu Wang, Hsin-An Chen, Tzu-Hsuan Wang, Chih-Ming Su, Po-Hsiang Liao, Alvin Chen, Kuei-Yen Tsai, George Kokotos, Cheng-Chin Kuo, Ching-Feng Chiu, Yen-Hao Su
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cancer & Metabolism
Subjects:
FOXO3a
Gemcitabine resistance
Lactate dehydrogenase A
microRNA-4259
Online Access:https://doi.org/10.1186/s40170-025-00377-3
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