Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal Adenocarcinomas
Adenocarcinomas of rectum and colon may be different with regard to the cellular biological basis for cancer development. A material of 246 rectal cancers removed surgically at Akershus University Hospital in the years 1992–2000 was investigated and was compared to a material of 219 colon cancers op...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2009/285830 |
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| author | Rolf Aamodt Kristin Jonsdottir Solveig Norheim Andersen Johan Bondi Geir Bukholm Ida R. K. Bukholm |
| author_facet | Rolf Aamodt Kristin Jonsdottir Solveig Norheim Andersen Johan Bondi Geir Bukholm Ida R. K. Bukholm |
| author_sort | Rolf Aamodt |
| collection | DOAJ |
| description | Adenocarcinomas of rectum and colon may be different with regard to the cellular biological basis for cancer development. A material of 246 rectal cancers removed surgically at Akershus University Hospital in the years 1992–2000 was investigated and was compared to a material of 219 colon cancers operated on at Akershus University Hospital during the years 1988, 1990 and 1997–2000. There were highly significant differences between the rectal and the colon cancers in the protein expression of cyclin D1, cyclin D3, cyclin E, nuclear β-catenin, and c-Myc and in gene amplification of cyclin A2, cyclin B1, cyclin D1, and cyclin E. Gene amplification and protein expression in the rectal cancers correlated significantly for the cyclins B1, D3, and E. A statistically significant relation was observed between overexpression of cyclin A2 and local relapse of rectal carcinomas, as higher expression of cyclin A2 was associated with lower local recurrence rate. |
| format | Article |
| id | doaj-art-e9074149b7b64980944550f886812e69 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-e9074149b7b64980944550f886812e692025-02-03T01:20:50ZengWileyGastroenterology Research and Practice1687-61211687-630X2009-01-01200910.1155/2009/285830285830Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal AdenocarcinomasRolf Aamodt0Kristin Jonsdottir1Solveig Norheim Andersen2Johan Bondi3Geir Bukholm4Ida R. K. Bukholm5Faculty Division Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, NorwayEpiGen, Faculty Division Akershus University Hospital, University of Oslo, 1478 Loerenskog, NorwayFaculty Division Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, NorwayDepartment of Surgery, Akershus University Hospital, 1478 Loerenskog, NorwayEpiGen, Faculty Division Akershus University Hospital, University of Oslo, 1478 Loerenskog, NorwayFaculty Division Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, NorwayAdenocarcinomas of rectum and colon may be different with regard to the cellular biological basis for cancer development. A material of 246 rectal cancers removed surgically at Akershus University Hospital in the years 1992–2000 was investigated and was compared to a material of 219 colon cancers operated on at Akershus University Hospital during the years 1988, 1990 and 1997–2000. There were highly significant differences between the rectal and the colon cancers in the protein expression of cyclin D1, cyclin D3, cyclin E, nuclear β-catenin, and c-Myc and in gene amplification of cyclin A2, cyclin B1, cyclin D1, and cyclin E. Gene amplification and protein expression in the rectal cancers correlated significantly for the cyclins B1, D3, and E. A statistically significant relation was observed between overexpression of cyclin A2 and local relapse of rectal carcinomas, as higher expression of cyclin A2 was associated with lower local recurrence rate.http://dx.doi.org/10.1155/2009/285830 |
| spellingShingle | Rolf Aamodt Kristin Jonsdottir Solveig Norheim Andersen Johan Bondi Geir Bukholm Ida R. K. Bukholm Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal Adenocarcinomas Gastroenterology Research and Practice |
| title | Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal Adenocarcinomas |
| title_full | Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal Adenocarcinomas |
| title_fullStr | Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal Adenocarcinomas |
| title_full_unstemmed | Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal Adenocarcinomas |
| title_short | Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal Adenocarcinomas |
| title_sort | differences in protein expression and gene amplification of cyclins between colon and rectal adenocarcinomas |
| url | http://dx.doi.org/10.1155/2009/285830 |
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