Imaging characteristics of renal epithelioid angiomyolipoma and its correlation with risk stratification
Abstract Renal epithelioid angiomyolipoma (EAML) is frequently misdiagnosed due to nonspecific imaging findings. This study aimed to explore the radiographic characteristics of EAML, with the goal of enhancing the accuracy of preoperative diagnoses. A total of 27 patients with histopathologically co...
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Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-15340-x |
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| author | Jin Zhou Guo-chu Qin Ting-ting Chen Le Cheng Li Zhu |
| author_facet | Jin Zhou Guo-chu Qin Ting-ting Chen Le Cheng Li Zhu |
| author_sort | Jin Zhou |
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| description | Abstract Renal epithelioid angiomyolipoma (EAML) is frequently misdiagnosed due to nonspecific imaging findings. This study aimed to explore the radiographic characteristics of EAML, with the goal of enhancing the accuracy of preoperative diagnoses. A total of 27 patients with histopathologically confirmed renal EAML were included in the study. We retrospectively reviewed the radiographic features and analyzed the differences between tumors with a cut-off diameter of 40 mm. The majority of the lesions were isolated (25/27, 92.59%) and were predominantly found in females (18/27, 66.67%). CT images revealed that most lesions were hyperdense, with fat detected in 13 cases. Small lesions were more likely to exhibit rapid wash-in and wash-out enhancement (p = 0.04), whereas abnormal vessels were more commonly found in large lesions. Tumors with higher risk stratification tended to show persistent or delayed enhancement on CT images. The imaging manifestations of renal EAML are diverse. After enhancement, small lesions are more likely to display rapid wash-in and wash-out patterns on CT images, whereas large lesions are more likely to exhibit abnormal vessels within or surrounding the tumor. |
| format | Article |
| id | doaj-art-e9062f229ca04a21ba9c9b5948d1a660 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-e9062f229ca04a21ba9c9b5948d1a6602025-08-20T03:47:12ZengNature PortfolioScientific Reports2045-23222025-08-0115111010.1038/s41598-025-15340-xImaging characteristics of renal epithelioid angiomyolipoma and its correlation with risk stratificationJin Zhou0Guo-chu Qin1Ting-ting Chen2Le Cheng3Li Zhu4Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Pathology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical UniversityDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityAbstract Renal epithelioid angiomyolipoma (EAML) is frequently misdiagnosed due to nonspecific imaging findings. This study aimed to explore the radiographic characteristics of EAML, with the goal of enhancing the accuracy of preoperative diagnoses. A total of 27 patients with histopathologically confirmed renal EAML were included in the study. We retrospectively reviewed the radiographic features and analyzed the differences between tumors with a cut-off diameter of 40 mm. The majority of the lesions were isolated (25/27, 92.59%) and were predominantly found in females (18/27, 66.67%). CT images revealed that most lesions were hyperdense, with fat detected in 13 cases. Small lesions were more likely to exhibit rapid wash-in and wash-out enhancement (p = 0.04), whereas abnormal vessels were more commonly found in large lesions. Tumors with higher risk stratification tended to show persistent or delayed enhancement on CT images. The imaging manifestations of renal EAML are diverse. After enhancement, small lesions are more likely to display rapid wash-in and wash-out patterns on CT images, whereas large lesions are more likely to exhibit abnormal vessels within or surrounding the tumor.https://doi.org/10.1038/s41598-025-15340-xAngiomyolipomaEpithelioid angiomyolipomaImaging featuresMRICT |
| spellingShingle | Jin Zhou Guo-chu Qin Ting-ting Chen Le Cheng Li Zhu Imaging characteristics of renal epithelioid angiomyolipoma and its correlation with risk stratification Scientific Reports Angiomyolipoma Epithelioid angiomyolipoma Imaging features MRI CT |
| title | Imaging characteristics of renal epithelioid angiomyolipoma and its correlation with risk stratification |
| title_full | Imaging characteristics of renal epithelioid angiomyolipoma and its correlation with risk stratification |
| title_fullStr | Imaging characteristics of renal epithelioid angiomyolipoma and its correlation with risk stratification |
| title_full_unstemmed | Imaging characteristics of renal epithelioid angiomyolipoma and its correlation with risk stratification |
| title_short | Imaging characteristics of renal epithelioid angiomyolipoma and its correlation with risk stratification |
| title_sort | imaging characteristics of renal epithelioid angiomyolipoma and its correlation with risk stratification |
| topic | Angiomyolipoma Epithelioid angiomyolipoma Imaging features MRI CT |
| url | https://doi.org/10.1038/s41598-025-15340-x |
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