Application and perspectives of nanomaterials in boron neutron capture therapy of tumors
Abstract Boron neutron capture therapy (BNCT) is a two-step targeted radiotherapy technique, which selectively delivers 10B atoms to tumor tissues, leading to selective tumor destruction through thermal neutron irradiation. BNCT, which utilizes boron agents, such as BPA and BSH, has demonstrated pro...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | Cancer Nanotechnology |
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| Online Access: | https://doi.org/10.1186/s12645-025-00324-3 |
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| author | Xiaomei Li Puyi He Yujie Wei Caihao Qu Futian Tang Yumin Li |
| author_facet | Xiaomei Li Puyi He Yujie Wei Caihao Qu Futian Tang Yumin Li |
| author_sort | Xiaomei Li |
| collection | DOAJ |
| description | Abstract Boron neutron capture therapy (BNCT) is a two-step targeted radiotherapy technique, which selectively delivers 10B atoms to tumor tissues, leading to selective tumor destruction through thermal neutron irradiation. BNCT, which utilizes boron agents, such as BPA and BSH, has demonstrated promising results in tumor treatment. However, it still faces several challenges, including insufficient tumor targeting, rapid in vivo metabolism, and high doses due to poor solubility. To address these challenges, nanotechnology-based boron drug delivery systems have emerged as a crucial strategy to enhance the therapeutic efficacy of BNCT. This paper thus summarizes the respective drug-carrying modes and provides an evaluation of the advantages and disadvantages of inorganic nanomaterials (e.g., gold nanoparticles, boron nanoparticles, carbon nanoparticles, silica nanoparticles, magnetic nanoparticles), organic nanomaterials (e.g., liposomes, polymer nanoparticles, dendritic macromolecules, micelles), and natural nanomaterials. In addition, we discuss pressing issues and future research directions regarding the use of nanomaterials as boron drug carriers, with the aim of offering valuable insights into the advancement of these materials in both basic and clinical research application. |
| format | Article |
| id | doaj-art-e905aff9d802492d988c55eab55d5efb |
| institution | OA Journals |
| issn | 1868-6958 1868-6966 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Nanotechnology |
| spelling | doaj-art-e905aff9d802492d988c55eab55d5efb2025-08-20T02:39:03ZengBMCCancer Nanotechnology1868-69581868-69662025-05-0116112310.1186/s12645-025-00324-3Application and perspectives of nanomaterials in boron neutron capture therapy of tumorsXiaomei Li0Puyi He1Yujie Wei2Caihao Qu3Futian Tang4Yumin Li5Lanzhou University Second HospitalLanzhou University Second HospitalLanzhou University Second HospitalLanzhou University Second HospitalLanzhou University Second HospitalLanzhou University Second HospitalAbstract Boron neutron capture therapy (BNCT) is a two-step targeted radiotherapy technique, which selectively delivers 10B atoms to tumor tissues, leading to selective tumor destruction through thermal neutron irradiation. BNCT, which utilizes boron agents, such as BPA and BSH, has demonstrated promising results in tumor treatment. However, it still faces several challenges, including insufficient tumor targeting, rapid in vivo metabolism, and high doses due to poor solubility. To address these challenges, nanotechnology-based boron drug delivery systems have emerged as a crucial strategy to enhance the therapeutic efficacy of BNCT. This paper thus summarizes the respective drug-carrying modes and provides an evaluation of the advantages and disadvantages of inorganic nanomaterials (e.g., gold nanoparticles, boron nanoparticles, carbon nanoparticles, silica nanoparticles, magnetic nanoparticles), organic nanomaterials (e.g., liposomes, polymer nanoparticles, dendritic macromolecules, micelles), and natural nanomaterials. In addition, we discuss pressing issues and future research directions regarding the use of nanomaterials as boron drug carriers, with the aim of offering valuable insights into the advancement of these materials in both basic and clinical research application.https://doi.org/10.1186/s12645-025-00324-3NanomaterialBoron neutron capture therapyBoron agentDrug delivery |
| spellingShingle | Xiaomei Li Puyi He Yujie Wei Caihao Qu Futian Tang Yumin Li Application and perspectives of nanomaterials in boron neutron capture therapy of tumors Cancer Nanotechnology Nanomaterial Boron neutron capture therapy Boron agent Drug delivery |
| title | Application and perspectives of nanomaterials in boron neutron capture therapy of tumors |
| title_full | Application and perspectives of nanomaterials in boron neutron capture therapy of tumors |
| title_fullStr | Application and perspectives of nanomaterials in boron neutron capture therapy of tumors |
| title_full_unstemmed | Application and perspectives of nanomaterials in boron neutron capture therapy of tumors |
| title_short | Application and perspectives of nanomaterials in boron neutron capture therapy of tumors |
| title_sort | application and perspectives of nanomaterials in boron neutron capture therapy of tumors |
| topic | Nanomaterial Boron neutron capture therapy Boron agent Drug delivery |
| url | https://doi.org/10.1186/s12645-025-00324-3 |
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