Enhancing the Total Terminal Galactosylation of CHO Cell-Derived TNF-α Blocker-IgG1 Monoclonal Antibody Using Time-Dependent Galactose Supplementation

Enhancing the Total Terminal Galactosylation of CHO Cell-Derived TNF-α Blocker-IgG1 Monoclonal Antibody Using Time-Dependent Galactose Supplementation

<b>Background:</b> Recombinant monoclonal antibodies represent a vital category of biologics, constituting the largest class of molecules used to treat autoimmune disorders, cancers, rheumatoid arthritis, and other chronic conditions. The IgG1 subclass is the most potent among all the im...

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Bibliographic Details
Main Authors: Mallikarjuna Pulipeta, Pradeep Kumar Iyer, Rajendra Kumar Palakurthy, Narasimha Pullaguri, Rajasekhar Pinnamaneni, Srinivas Reddy Chilukuri
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biologics
Subjects:
TNF-α blocker-IgG1
Chinese hamster ovary (CHO) cells
galactose
cell culture parameters
galactosylation
Online Access:https://www.mdpi.com/2673-8449/5/2/16
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