GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis
Objective. To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis. Methods. This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/5141089 |
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| author | Wenli Song Xian’e Wang Yu Tian Xin Zhang Ruifang Lu Huanxin Meng |
| author_facet | Wenli Song Xian’e Wang Yu Tian Xin Zhang Ruifang Lu Huanxin Meng |
| author_sort | Wenli Song |
| collection | DOAJ |
| description | Objective. To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis. Methods. This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy subjects (group HP). GC rs17467825, rs4588, and rs7041 genotypes and plasmatic vitamin D-binding protein (DBP) were measured. Analysis of single SNP and multiple SNPs was performed and relevance between plasmatic DBP and haplotypes was analyzed. Results. GC rs17467825 GG genotype was statistically associated with lower risk for generalized aggressive periodontitis under the recessive model (OR = 0.52, 95% CI: 0.30–0.92, p=0.028). GC rs17467825 and rs4588 had strong linkage disequilibrium with r2≥0.8 and D′≥0.8. Haplotype (GC rs17467825, rs4588) GC was associated with the less risk for generalized aggressive periodontitis (OR = 0.29, 95% CI: 0.09–0.96, p=0.043). In group AgP, individuals with combined genotype (GC rs17467825, rs4588) AG+CA had significantly lower plasmatic DBP level than those with the other two combined genotypes (AG+CA versus AA+CC p=0.007; AG+CA versus GG+AA p=0.026). Conclusions. GC rs17467825 genotype GG and haplotype (GC rs17467825, rs4588) GC are associated with generalized aggressive periodontitis. The association may be acquired through regulating DBP levels. The functions of GC gene and DBP in inflammatory disease need to be further studied. |
| format | Article |
| id | doaj-art-e8ff710bbe6b46a7b78155fbaf7fe79d |
| institution | DOAJ |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e8ff710bbe6b46a7b78155fbaf7fe79d2025-08-20T03:21:09ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/51410895141089GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive PeriodontitisWenli Song0Xian’e Wang1Yu Tian2Xin Zhang3Ruifang Lu4Huanxin Meng5Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, ChinaDepartment of Periodontology, Peking University School and Hospital of Stomatology, Beijing, ChinaDepartment of General Dentistry, First Dental Center, Peking University School and Hospital of Stomatology, Beijing, ChinaDepartment of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, ChinaDepartment of Periodontology, Peking University School and Hospital of Stomatology, Beijing, ChinaDepartment of Periodontology, Peking University School and Hospital of Stomatology, Beijing, ChinaObjective. To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis. Methods. This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy subjects (group HP). GC rs17467825, rs4588, and rs7041 genotypes and plasmatic vitamin D-binding protein (DBP) were measured. Analysis of single SNP and multiple SNPs was performed and relevance between plasmatic DBP and haplotypes was analyzed. Results. GC rs17467825 GG genotype was statistically associated with lower risk for generalized aggressive periodontitis under the recessive model (OR = 0.52, 95% CI: 0.30–0.92, p=0.028). GC rs17467825 and rs4588 had strong linkage disequilibrium with r2≥0.8 and D′≥0.8. Haplotype (GC rs17467825, rs4588) GC was associated with the less risk for generalized aggressive periodontitis (OR = 0.29, 95% CI: 0.09–0.96, p=0.043). In group AgP, individuals with combined genotype (GC rs17467825, rs4588) AG+CA had significantly lower plasmatic DBP level than those with the other two combined genotypes (AG+CA versus AA+CC p=0.007; AG+CA versus GG+AA p=0.026). Conclusions. GC rs17467825 genotype GG and haplotype (GC rs17467825, rs4588) GC are associated with generalized aggressive periodontitis. The association may be acquired through regulating DBP levels. The functions of GC gene and DBP in inflammatory disease need to be further studied.http://dx.doi.org/10.1155/2016/5141089 |
| spellingShingle | Wenli Song Xian’e Wang Yu Tian Xin Zhang Ruifang Lu Huanxin Meng GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis International Journal of Endocrinology |
| title | GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis |
| title_full | GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis |
| title_fullStr | GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis |
| title_full_unstemmed | GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis |
| title_short | GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis |
| title_sort | gc gene polymorphisms and vitamin d binding protein levels are related to the risk of generalized aggressive periodontitis |
| url | http://dx.doi.org/10.1155/2016/5141089 |
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