Adverse cardiovascular outcomes and their relationship with risk factors according to the prospective study MERIDIAN-RO
Aim. To assess the incidence of adverse outcomes and the role of main risk factors in their development.Material and methods. Prospective, long-term study was conducted with observation period of 36 months. The sample in the MERIDIAN-RO study was formed from the urban and rural population. It includ...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2019-07-01
|
| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/3353 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849690040158912512 |
|---|---|
| author | E. V. Filippov A. N. Vorobyev N. V. Dobrynina L. A. Zotova E. V. Lygina N. N. Nikulina S. V. Seleznev S. S. Yakushin |
| author_facet | E. V. Filippov A. N. Vorobyev N. V. Dobrynina L. A. Zotova E. V. Lygina N. N. Nikulina S. V. Seleznev S. S. Yakushin |
| author_sort | E. V. Filippov |
| collection | DOAJ |
| description | Aim. To assess the incidence of adverse outcomes and the role of main risk factors in their development.Material and methods. Prospective, long-term study was conducted with observation period of 36 months. The sample in the MERIDIAN-RO study was formed from the urban and rural population. It included 1622 people aged 25-64 years. The response to the study was 86,1%. Observation and screening of endpoints continued for 36 months. The endpoints were: all-cause death, ischemic stroke, myocardial infarction, coronary artery revascularization.Results. When studying the relationship between various risk factors and outcomes, it was found that they had a significant impact on the combined endpoint (all-cause death + nonfatal ischemic stroke + nonfatal myocardial infarction): risk SCORE >5% (odds ratio (OR) 5,80, 95% confidence interval (CI) 2,31-14,58, p=0,0001, Wald — 23,040), excessive alcohol consumption (OR 714, 95% CI 1,41-36,31, p=0,018, Wald — 2,908), arterial hypertension (OR 4,77 95% CI 1,91-11,90, p=0,01, Wald — 9,000), combination of coronary artery disease/myocardial infarction/stroke in history (OR 11,16, 95% CI 3,98-31,31, p=0,0001, Wald — 22,607) and an apolipoprotein B increase more than 180 mg/dL (OR 28,57 95% CI 732-111,42, p=0,0001, Wald — 24,509).Conclusion. The most significant effect on the combined endpoint (all-cause death + nonfatal myocardial infarction + nonfatal stroke) made: SCORE risk >5%, excessive alcohol consumption, hypertension, combination of coronary artery disease/myocardial infarction/stroke in history and an apolipoprotein B increase more than 180 mg/dL. That should be considered when choosing aims and preventive strategies. |
| format | Article |
| id | doaj-art-e8fe747917804cd388b0990ecf4cce59 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2019-07-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-e8fe747917804cd388b0990ecf4cce592025-08-20T03:21:26Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202019-07-0106424810.15829/1560-4071-2019-6-42-482685Adverse cardiovascular outcomes and their relationship with risk factors according to the prospective study MERIDIAN-ROE. V. Filippov0A. N. Vorobyev1N. V. Dobrynina2L. A. Zotova3E. V. Lygina4N. N. Nikulina5S. V. Seleznev6S. S. Yakushin7I. P. Pavlov Ryazan State Medical UniversityI. P. Pavlov Ryazan State Medical UniversityI. P. Pavlov Ryazan State Medical UniversityI. P. Pavlov Ryazan State Medical UniversityI. P. Pavlov Ryazan State Medical UniversityI. P. Pavlov Ryazan State Medical UniversityI. P. Pavlov Ryazan State Medical UniversityI. P. Pavlov Ryazan State Medical UniversityAim. To assess the incidence of adverse outcomes and the role of main risk factors in their development.Material and methods. Prospective, long-term study was conducted with observation period of 36 months. The sample in the MERIDIAN-RO study was formed from the urban and rural population. It included 1622 people aged 25-64 years. The response to the study was 86,1%. Observation and screening of endpoints continued for 36 months. The endpoints were: all-cause death, ischemic stroke, myocardial infarction, coronary artery revascularization.Results. When studying the relationship between various risk factors and outcomes, it was found that they had a significant impact on the combined endpoint (all-cause death + nonfatal ischemic stroke + nonfatal myocardial infarction): risk SCORE >5% (odds ratio (OR) 5,80, 95% confidence interval (CI) 2,31-14,58, p=0,0001, Wald — 23,040), excessive alcohol consumption (OR 714, 95% CI 1,41-36,31, p=0,018, Wald — 2,908), arterial hypertension (OR 4,77 95% CI 1,91-11,90, p=0,01, Wald — 9,000), combination of coronary artery disease/myocardial infarction/stroke in history (OR 11,16, 95% CI 3,98-31,31, p=0,0001, Wald — 22,607) and an apolipoprotein B increase more than 180 mg/dL (OR 28,57 95% CI 732-111,42, p=0,0001, Wald — 24,509).Conclusion. The most significant effect on the combined endpoint (all-cause death + nonfatal myocardial infarction + nonfatal stroke) made: SCORE risk >5%, excessive alcohol consumption, hypertension, combination of coronary artery disease/myocardial infarction/stroke in history and an apolipoprotein B increase more than 180 mg/dL. That should be considered when choosing aims and preventive strategies.https://russjcardiol.elpub.ru/jour/article/view/3353cardiovascular outcomesprospective studyrisk factorsmeridian-ro |
| spellingShingle | E. V. Filippov A. N. Vorobyev N. V. Dobrynina L. A. Zotova E. V. Lygina N. N. Nikulina S. V. Seleznev S. S. Yakushin Adverse cardiovascular outcomes and their relationship with risk factors according to the prospective study MERIDIAN-RO Российский кардиологический журнал cardiovascular outcomes prospective study risk factors meridian-ro |
| title | Adverse cardiovascular outcomes and their relationship with risk factors according to the prospective study MERIDIAN-RO |
| title_full | Adverse cardiovascular outcomes and their relationship with risk factors according to the prospective study MERIDIAN-RO |
| title_fullStr | Adverse cardiovascular outcomes and their relationship with risk factors according to the prospective study MERIDIAN-RO |
| title_full_unstemmed | Adverse cardiovascular outcomes and their relationship with risk factors according to the prospective study MERIDIAN-RO |
| title_short | Adverse cardiovascular outcomes and their relationship with risk factors according to the prospective study MERIDIAN-RO |
| title_sort | adverse cardiovascular outcomes and their relationship with risk factors according to the prospective study meridian ro |
| topic | cardiovascular outcomes prospective study risk factors meridian-ro |
| url | https://russjcardiol.elpub.ru/jour/article/view/3353 |
| work_keys_str_mv | AT evfilippov adversecardiovascularoutcomesandtheirrelationshipwithriskfactorsaccordingtotheprospectivestudymeridianro AT anvorobyev adversecardiovascularoutcomesandtheirrelationshipwithriskfactorsaccordingtotheprospectivestudymeridianro AT nvdobrynina adversecardiovascularoutcomesandtheirrelationshipwithriskfactorsaccordingtotheprospectivestudymeridianro AT lazotova adversecardiovascularoutcomesandtheirrelationshipwithriskfactorsaccordingtotheprospectivestudymeridianro AT evlygina adversecardiovascularoutcomesandtheirrelationshipwithriskfactorsaccordingtotheprospectivestudymeridianro AT nnnikulina adversecardiovascularoutcomesandtheirrelationshipwithriskfactorsaccordingtotheprospectivestudymeridianro AT svseleznev adversecardiovascularoutcomesandtheirrelationshipwithriskfactorsaccordingtotheprospectivestudymeridianro AT ssyakushin adversecardiovascularoutcomesandtheirrelationshipwithriskfactorsaccordingtotheprospectivestudymeridianro |