Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled Study
Transforaminal steroid injection is extensively used as a treatment in cases of herniated disc, but it is associated with complications. In comparison, platelet-rich plasma (PRP) injection has been used in musculoskeletal disorders and could be another option. This study is aimed at comparing the ef...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/5558138 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849691011223126016 |
|---|---|
| author | Zhen Xu Shaoling Wu Xiao Li Cuicui Liu Shengnuo Fan Chao Ma |
| author_facet | Zhen Xu Shaoling Wu Xiao Li Cuicui Liu Shengnuo Fan Chao Ma |
| author_sort | Zhen Xu |
| collection | DOAJ |
| description | Transforaminal steroid injection is extensively used as a treatment in cases of herniated disc, but it is associated with complications. In comparison, platelet-rich plasma (PRP) injection has been used in musculoskeletal disorders and could be another option. This study is aimed at comparing the efficacy and safety aspects between ultrasound-guided transforaminal injections of PRP and steroid in patients who suffer from radicular pain due to lumbar disc herniation. In a randomized controlled trial, ultrasound-guided transforaminal injections of either PRP (n=61) or steroid (n=63) were administered to a total of 124 patients who suffer from radicular pain due to lumbar disc herniation. Patients were assessed by the visual analogue scale (VAS), pressure pain thresholds (PPTs), Oswestry disability index (ODI), and the physical function (PF) and bodily pain (BP) domains of the 36-item short form health survey (SF-36) before operation and 1 week, 1 month, 3 months, 6 months, and 12 months after operation. The rate and latency of F-wave were obtained before operation and 12 months postoperation. There was no statistical difference in terms of age and sex between both groups. Statistically significant improvements from the patients’ data before operation to data obtained 1-month postoperation were observed in VAS, PPTs, ODI, and PF and BP of SF-36 in both groups and kept for 1 year. F-wave rate and latency were improved significantly at 1-year postoperation in both groups. Intergroup differences during follow-ups over a period of 1 year were not found to be significant in all the above assessment between the PRP and steroid groups. No complications were reported. The results showed similar outcome for both transforaminal injections using PRP and steroid in the treatment of lumbar disc herniation, suggesting the possible application of PRP injection as a safer alternative. The trial was registered in the Chinese Clinical Trial Registry (ChiCTR-INR-17011825). |
| format | Article |
| id | doaj-art-e8fc770bfb0d43418e831a2909879e32 |
| institution | DOAJ |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e8fc770bfb0d43418e831a2909879e322025-08-20T03:21:09ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/55581385558138Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled StudyZhen Xu0Shaoling Wu1Xiao Li2Cuicui Liu3Shengnuo Fan4Chao Ma5Department of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, ChinaDepartment of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, ChinaDepartment of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, ChinaDepartment of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, ChinaDepartment of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, ChinaDepartment of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, ChinaTransforaminal steroid injection is extensively used as a treatment in cases of herniated disc, but it is associated with complications. In comparison, platelet-rich plasma (PRP) injection has been used in musculoskeletal disorders and could be another option. This study is aimed at comparing the efficacy and safety aspects between ultrasound-guided transforaminal injections of PRP and steroid in patients who suffer from radicular pain due to lumbar disc herniation. In a randomized controlled trial, ultrasound-guided transforaminal injections of either PRP (n=61) or steroid (n=63) were administered to a total of 124 patients who suffer from radicular pain due to lumbar disc herniation. Patients were assessed by the visual analogue scale (VAS), pressure pain thresholds (PPTs), Oswestry disability index (ODI), and the physical function (PF) and bodily pain (BP) domains of the 36-item short form health survey (SF-36) before operation and 1 week, 1 month, 3 months, 6 months, and 12 months after operation. The rate and latency of F-wave were obtained before operation and 12 months postoperation. There was no statistical difference in terms of age and sex between both groups. Statistically significant improvements from the patients’ data before operation to data obtained 1-month postoperation were observed in VAS, PPTs, ODI, and PF and BP of SF-36 in both groups and kept for 1 year. F-wave rate and latency were improved significantly at 1-year postoperation in both groups. Intergroup differences during follow-ups over a period of 1 year were not found to be significant in all the above assessment between the PRP and steroid groups. No complications were reported. The results showed similar outcome for both transforaminal injections using PRP and steroid in the treatment of lumbar disc herniation, suggesting the possible application of PRP injection as a safer alternative. The trial was registered in the Chinese Clinical Trial Registry (ChiCTR-INR-17011825).http://dx.doi.org/10.1155/2021/5558138 |
| spellingShingle | Zhen Xu Shaoling Wu Xiao Li Cuicui Liu Shengnuo Fan Chao Ma Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled Study Neural Plasticity |
| title | Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled Study |
| title_full | Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled Study |
| title_fullStr | Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled Study |
| title_full_unstemmed | Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled Study |
| title_short | Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled Study |
| title_sort | ultrasound guided transforaminal injections of platelet rich plasma compared with steroid in lumbar disc herniation a prospective randomized controlled study |
| url | http://dx.doi.org/10.1155/2021/5558138 |
| work_keys_str_mv | AT zhenxu ultrasoundguidedtransforaminalinjectionsofplateletrichplasmacomparedwithsteroidinlumbardischerniationaprospectiverandomizedcontrolledstudy AT shaolingwu ultrasoundguidedtransforaminalinjectionsofplateletrichplasmacomparedwithsteroidinlumbardischerniationaprospectiverandomizedcontrolledstudy AT xiaoli ultrasoundguidedtransforaminalinjectionsofplateletrichplasmacomparedwithsteroidinlumbardischerniationaprospectiverandomizedcontrolledstudy AT cuicuiliu ultrasoundguidedtransforaminalinjectionsofplateletrichplasmacomparedwithsteroidinlumbardischerniationaprospectiverandomizedcontrolledstudy AT shengnuofan ultrasoundguidedtransforaminalinjectionsofplateletrichplasmacomparedwithsteroidinlumbardischerniationaprospectiverandomizedcontrolledstudy AT chaoma ultrasoundguidedtransforaminalinjectionsofplateletrichplasmacomparedwithsteroidinlumbardischerniationaprospectiverandomizedcontrolledstudy |