Characteristics of Metallic Nanoparticles (Especially Silver Nanoparticles) as Anti-Biofilm Agents
Biofilm-associated infections account for a large proportion of chronic diseases and pose a major health challenge. Metal nanoparticles offer a new way to address this problem, by impairing microbial growth and biofilm formation and by causing degradation of existing biofilms. This review of metal n...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-08-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/13/9/819 |
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| author | Hongze Li Zhihe Yang Sadaf Aiman Khan Laurence J. Walsh Chaminda Jayampath Seneviratne Zyta M. Ziora |
| author_facet | Hongze Li Zhihe Yang Sadaf Aiman Khan Laurence J. Walsh Chaminda Jayampath Seneviratne Zyta M. Ziora |
| author_sort | Hongze Li |
| collection | DOAJ |
| description | Biofilm-associated infections account for a large proportion of chronic diseases and pose a major health challenge. Metal nanoparticles offer a new way to address this problem, by impairing microbial growth and biofilm formation and by causing degradation of existing biofilms. This review of metal nanoparticles with antimicrobial actions included an analysis of 20 years of journal papers and patent applications, highlighting the progress over that time. A network analysis of relevant publications showed a major focus on the eradication of single-species biofilms formed under laboratory conditions, while a bibliometric analysis showed growing interest in combining different types of metal nanoparticles with one another or with antibiotics. The analysis of patent applications showed considerable growth over time, but with relatively few patents progressing to be granted. Overall, this profile shows that intense interest in metal nanoparticles as anti-biofilm agents is progressing beyond the confines of simple laboratory biofilm models and coming closer to clinical application. Looking to the future, metal nanoparticles may provide a sustainable approach to combatting biofilms of drug-resistant bacteria. |
| format | Article |
| id | doaj-art-e8fb920fc1d64ab6b6762a6409a40de4 |
| institution | OA Journals |
| issn | 2079-6382 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-e8fb920fc1d64ab6b6762a6409a40de42025-08-20T01:56:04ZengMDPI AGAntibiotics2079-63822024-08-0113981910.3390/antibiotics13090819Characteristics of Metallic Nanoparticles (Especially Silver Nanoparticles) as Anti-Biofilm AgentsHongze Li0Zhihe Yang1Sadaf Aiman Khan2Laurence J. Walsh3Chaminda Jayampath Seneviratne4Zyta M. Ziora5School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD 4072, AustraliaSchool of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD 4072, AustraliaOral Health Centre, School of Dentistry, The University of Queensland, Herston, QLD 4006, AustraliaOral Health Centre, School of Dentistry, The University of Queensland, Herston, QLD 4006, AustraliaOral Health Centre, School of Dentistry, The University of Queensland, Herston, QLD 4006, AustraliaInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, AustraliaBiofilm-associated infections account for a large proportion of chronic diseases and pose a major health challenge. Metal nanoparticles offer a new way to address this problem, by impairing microbial growth and biofilm formation and by causing degradation of existing biofilms. This review of metal nanoparticles with antimicrobial actions included an analysis of 20 years of journal papers and patent applications, highlighting the progress over that time. A network analysis of relevant publications showed a major focus on the eradication of single-species biofilms formed under laboratory conditions, while a bibliometric analysis showed growing interest in combining different types of metal nanoparticles with one another or with antibiotics. The analysis of patent applications showed considerable growth over time, but with relatively few patents progressing to be granted. Overall, this profile shows that intense interest in metal nanoparticles as anti-biofilm agents is progressing beyond the confines of simple laboratory biofilm models and coming closer to clinical application. Looking to the future, metal nanoparticles may provide a sustainable approach to combatting biofilms of drug-resistant bacteria.https://www.mdpi.com/2079-6382/13/9/819antimicrobial agentsbiofilmmetallic nanoparticlesbimetallic nanoparticlessilver nanoparticles |
| spellingShingle | Hongze Li Zhihe Yang Sadaf Aiman Khan Laurence J. Walsh Chaminda Jayampath Seneviratne Zyta M. Ziora Characteristics of Metallic Nanoparticles (Especially Silver Nanoparticles) as Anti-Biofilm Agents Antibiotics antimicrobial agents biofilm metallic nanoparticles bimetallic nanoparticles silver nanoparticles |
| title | Characteristics of Metallic Nanoparticles (Especially Silver Nanoparticles) as Anti-Biofilm Agents |
| title_full | Characteristics of Metallic Nanoparticles (Especially Silver Nanoparticles) as Anti-Biofilm Agents |
| title_fullStr | Characteristics of Metallic Nanoparticles (Especially Silver Nanoparticles) as Anti-Biofilm Agents |
| title_full_unstemmed | Characteristics of Metallic Nanoparticles (Especially Silver Nanoparticles) as Anti-Biofilm Agents |
| title_short | Characteristics of Metallic Nanoparticles (Especially Silver Nanoparticles) as Anti-Biofilm Agents |
| title_sort | characteristics of metallic nanoparticles especially silver nanoparticles as anti biofilm agents |
| topic | antimicrobial agents biofilm metallic nanoparticles bimetallic nanoparticles silver nanoparticles |
| url | https://www.mdpi.com/2079-6382/13/9/819 |
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