The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancer
HOXC13 antisense RNA (HOXC13-AS, also known as HOXC-AS5) is a long non-coding RNA that is expressed abnormally in various types of tumors and is closely related to clinical staging, clinical pathological features, and patient survival. HOXC13-AS is involved in the occurrence and development of tumor...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1540048/full |
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| author | Xiaosi Gu Xin Hu Sijia Zhang Xiaoyu Zhang Yong Wang Lianlian Li Lianlian Li |
| author_facet | Xiaosi Gu Xin Hu Sijia Zhang Xiaoyu Zhang Yong Wang Lianlian Li Lianlian Li |
| author_sort | Xiaosi Gu |
| collection | DOAJ |
| description | HOXC13 antisense RNA (HOXC13-AS, also known as HOXC-AS5) is a long non-coding RNA that is expressed abnormally in various types of tumors and is closely related to clinical staging, clinical pathological features, and patient survival. HOXC13-AS is involved in the occurrence and development of tumors, affecting cell proliferation, migration, invasion, epithelial–mesenchymal transition, and tumor growth. This review summarizes the clinical significance of HOXC13-AS as a biomarker for human tumor diagnosis and prognosis and outlines the function and molecular regulation mechanism of HOXC13-AS in various types of cancer, including nasopharyngeal carcinoma, breast cancer, oral squamous cell carcinoma, glioma, and cervical cancer. Overall, this review emphasizes the potential of HOXC13-AS as a human tumor predictive biomarker and therapeutic target, paving the way for its clinical application. |
| format | Article |
| id | doaj-art-e8fb8809941343e8ac3e026a38d9f336 |
| institution | Kabale University |
| issn | 2296-889X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-e8fb8809941343e8ac3e026a38d9f3362025-02-06T05:21:50ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-02-011210.3389/fmolb.2025.15400481540048The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancerXiaosi Gu0Xin Hu1Sijia Zhang2Xiaoyu Zhang3Yong Wang4Lianlian Li5Lianlian Li6Department of Immunology, School of Clinical and Basic Medical Sciences, Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Immunology, School of Clinical and Basic Medical Sciences, Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Immunology, School of Clinical and Basic Medical Sciences, Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Immunology, School of Clinical and Basic Medical Sciences, Shandong First Medical University, Jinan, Shandong, ChinaShandong Provincial Engineering Research Center for Bacterial Oncolysis and Cell Treatment, Jinan, Shandong, ChinaDepartment of Immunology, School of Clinical and Basic Medical Sciences, Shandong First Medical University, Jinan, Shandong, ChinaLaboratory of Metabolism and Gastrointestinal Tumor, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, ChinaHOXC13 antisense RNA (HOXC13-AS, also known as HOXC-AS5) is a long non-coding RNA that is expressed abnormally in various types of tumors and is closely related to clinical staging, clinical pathological features, and patient survival. HOXC13-AS is involved in the occurrence and development of tumors, affecting cell proliferation, migration, invasion, epithelial–mesenchymal transition, and tumor growth. This review summarizes the clinical significance of HOXC13-AS as a biomarker for human tumor diagnosis and prognosis and outlines the function and molecular regulation mechanism of HOXC13-AS in various types of cancer, including nasopharyngeal carcinoma, breast cancer, oral squamous cell carcinoma, glioma, and cervical cancer. Overall, this review emphasizes the potential of HOXC13-AS as a human tumor predictive biomarker and therapeutic target, paving the way for its clinical application.https://www.frontiersin.org/articles/10.3389/fmolb.2025.1540048/fulllong non-coding RNAHOXC13 antisense RNAhuman tumorsbiological markerregulatory mechanisms |
| spellingShingle | Xiaosi Gu Xin Hu Sijia Zhang Xiaoyu Zhang Yong Wang Lianlian Li Lianlian Li The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancer Frontiers in Molecular Biosciences long non-coding RNA HOXC13 antisense RNA human tumors biological marker regulatory mechanisms |
| title | The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancer |
| title_full | The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancer |
| title_fullStr | The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancer |
| title_full_unstemmed | The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancer |
| title_short | The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancer |
| title_sort | diagnostic and prognostic significance of hoxc13 as and its molecular regulatory mechanism in human cancer |
| topic | long non-coding RNA HOXC13 antisense RNA human tumors biological marker regulatory mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1540048/full |
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