Poly(ADP-ribose)polymerase 2 is zinc-dependent enzyme and nucleosome reorganizer

Poly(ADP-ribose)polymerase 2 is zinc-dependent enzyme and nucleosome reorganizer

Abstract Poly(ADP-ribose)polymerase 2 (PARP2) is a nuclear protein, DNA damage sensor and an emerging target for development of anti-cancer drugs. Previously it was discovered that PARP2 binds to nucleosomes; however, critical factors involved in this process remain unknown. We demonstrated that in...

Full description

Saved in:
Bibliographic Details
Main Authors: Natalya Maluchenko, Alexandra Saulina, Olga Geraskina, Elena Kotova, Anna Korovina, Grigoriy Armeev, Mikhail Kirpichnikov, Alexey Feofanov, Vasily Studitsky
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cellular and Molecular Life Sciences
Subjects:
PARP2
Zn2+
Mg2+
AutoPARylation
SpFRET microscopy
EMSA
Online Access:https://doi.org/10.1007/s00018-025-05785-8
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items