IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy

IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy

BackgroundThe IL-33/ST2 axis plays a pivotal role in the development of IgE-mediated mast cell (MC) responses during food allergy. We recently demonstrated that the pleiotropic cytokine, IL-10, not only exerts proinflammatory effects on IgE-mediated MC activation, but also promotes IL-33-induced MC...

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Bibliographic Details
Main Authors: Dylan Krajewski, Saurav Ranjitkar, Nathan Jordan, Sallie S. Schneider, Clinton B. Mathias
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
mast cells
food allergy
IL-10
IL-33
allergy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526498/full
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