Effects of the combination of anti-PcrV antibody and bacteriophage therapy in a mouse model of Pseudomonas aeruginosa pneumonia

Effects of the combination of anti-PcrV antibody and bacteriophage therapy in a mouse model of Pseudomonas aeruginosa pneumonia

ABSTRACT Acute lung injury caused by Pseudomonas aeruginosa is attributed to the translocation of cytotoxin into pulmonary epithelial cells via the P. aeruginosa type III secretion system. This virulence can be blocked with a specific antibody against PcrV in this secretion system. However, because...

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Main Authors: Ohara Junya, Fujiki Jumpei, Mao Kinoshita, Kazuki Sudo, Ken Kawaguchi, Keita Inoue, Yoshifumi Naito, Kiyoshi Moriyama, Tomohiro Nakamura, Hidetomo Iwano, Teiji Sawa
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:Microbiology Spectrum
Subjects:
bacteriophage therapy
PcrV
Pseudomonas aeruginosa
acute lung injury
type III secretion system
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01781-24
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