Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma
The proportion of obese or diabetic population has been anticipated to increase in the upcoming decades, which rises the prevalence of nonalcoholic fatty liver disease (NAFLD) and its progression to nonalcoholic steatohepatitis (NASH). Recent evidence indicates that NASH is the main cause of chronic...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/8543763 |
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| author | Ozlem Kutlu Humeyra Nur Kaleli Ebru Ozer |
| author_facet | Ozlem Kutlu Humeyra Nur Kaleli Ebru Ozer |
| author_sort | Ozlem Kutlu |
| collection | DOAJ |
| description | The proportion of obese or diabetic population has been anticipated to increase in the upcoming decades, which rises the prevalence of nonalcoholic fatty liver disease (NAFLD) and its progression to nonalcoholic steatohepatitis (NASH). Recent evidence indicates that NASH is the main cause of chronic liver diseases and it is an important risk factor for development of hepatocellular carcinoma (HCC). Although the literature addressing NASH-HCC is growing rapidly, limited data is available about the etiology of NASH-related HCC. Experimental studies on the molecular mechanism of HCC development in NASH reveal that the carcinogenesis is relevant to complex changes in signaling pathways that mediate cell proliferation and energy metabolism. Genetic or epigenetic modifications and alterations in metabolic, immunologic, and endocrine pathways have been shown to be closely related to inflammation, liver injury, and fibrosis in NASH along with its subsequent progression to HCC. In this review, we provide an overview on the current knowledge of NASH-related HCC development and emphasize molecular signaling pathways regarding their mechanism of action in NASH-derived HCC. |
| format | Article |
| id | doaj-art-e8f4ee7e14834598997d694edfe7c2d0 |
| institution | OA Journals |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-e8f4ee7e14834598997d694edfe7c2d02025-08-20T02:21:53ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972018-01-01201810.1155/2018/85437638543763Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular CarcinomaOzlem Kutlu0Humeyra Nur Kaleli1Ebru Ozer2Nanotechnology Research and Application Center, Sabanci University, Istanbul, TurkeyMolecular Biology, Genetics and Bioengineering Program, Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, TurkeyMolecular Biology, Genetics and Bioengineering Program, Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, TurkeyThe proportion of obese or diabetic population has been anticipated to increase in the upcoming decades, which rises the prevalence of nonalcoholic fatty liver disease (NAFLD) and its progression to nonalcoholic steatohepatitis (NASH). Recent evidence indicates that NASH is the main cause of chronic liver diseases and it is an important risk factor for development of hepatocellular carcinoma (HCC). Although the literature addressing NASH-HCC is growing rapidly, limited data is available about the etiology of NASH-related HCC. Experimental studies on the molecular mechanism of HCC development in NASH reveal that the carcinogenesis is relevant to complex changes in signaling pathways that mediate cell proliferation and energy metabolism. Genetic or epigenetic modifications and alterations in metabolic, immunologic, and endocrine pathways have been shown to be closely related to inflammation, liver injury, and fibrosis in NASH along with its subsequent progression to HCC. In this review, we provide an overview on the current knowledge of NASH-related HCC development and emphasize molecular signaling pathways regarding their mechanism of action in NASH-derived HCC.http://dx.doi.org/10.1155/2018/8543763 |
| spellingShingle | Ozlem Kutlu Humeyra Nur Kaleli Ebru Ozer Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma Canadian Journal of Gastroenterology and Hepatology |
| title | Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma |
| title_full | Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma |
| title_fullStr | Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma |
| title_full_unstemmed | Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma |
| title_short | Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma |
| title_sort | molecular pathogenesis of nonalcoholic steatohepatitis nash related hepatocellular carcinoma |
| url | http://dx.doi.org/10.1155/2018/8543763 |
| work_keys_str_mv | AT ozlemkutlu molecularpathogenesisofnonalcoholicsteatohepatitisnashrelatedhepatocellularcarcinoma AT humeyranurkaleli molecularpathogenesisofnonalcoholicsteatohepatitisnashrelatedhepatocellularcarcinoma AT ebruozer molecularpathogenesisofnonalcoholicsteatohepatitisnashrelatedhepatocellularcarcinoma |