Global collaboration and innovation in malignant cerebral edema research: a bibliometric perspective
AimMalignant cerebral edema (MCE) is a life-threatening complication of acute brain injuries, with mortality rates exceeding 80% in the absence of treatment. Despite advancements in osmotic therapies and decompressive craniectomy (DC), MCE continues to pose substantial clinical challenges. This stud...
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| Format: | Article |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1624101/full |
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| author | Xinhua Peng Xinhua Peng Rongrong Zhu Ke Zhang Jianghong Ji Chuanguo Lv Feng Feng Feng Feng |
| author_facet | Xinhua Peng Xinhua Peng Rongrong Zhu Ke Zhang Jianghong Ji Chuanguo Lv Feng Feng Feng Feng |
| author_sort | Xinhua Peng |
| collection | DOAJ |
| description | AimMalignant cerebral edema (MCE) is a life-threatening complication of acute brain injuries, with mortality rates exceeding 80% in the absence of treatment. Despite advancements in osmotic therapies and decompressive craniectomy (DC), MCE continues to pose substantial clinical challenges. This study systematically maps the evolution of MCE research (2005–2024) to identify key trends, research gaps, and future priorities.MethodsA bibliometric analysis of 1,460 peer-reviewed articles from the Web of Science Core Collection was conducted using CiteSpace, VOSviewer, and Bibliometrix. Key metrics included publication trends, geographic and institutional contributions, keyword co-occurrence, citation networks, and co-authorship patterns.ResultsAnnual publications increased from 55 in 2005 to 128 in 2024, progressing through three distinct phases: Foundational growth (2005–2009), consolidation (2010–2014), and rapid expansion (2015–2024). The United States (28.9%) and China (18.7%) dominated research output, with Harvard University and the University of California System leading institutional collaboration clusters. High-impact journals highlighted clinical advancements, including Stroke (h-index = 27). Keyword analysis demonstrated a thematic progression from blood–brain barrier pathophysiology to clinical innovations, including DC and emerging predictive modeling techniques incorporating machine learning. Landmark trials, including DECIMAL and HAMLET, validated early surgical intervention, while emerging trends have emphasized precision medicine and artificial intelligence (AI)-driven risk stratification.ConclusionThe MCE research has transitioned from foundational pathophysiology to interdisciplinary clinical practice and data integration. However, critical gaps remain, including underrepresentation in pediatric research, disparities in global neurocritical care, and challenges in translational application. Future priorities should focus on biomarker discovery, equitable global collaborations, and AI-enhanced frameworks to transform survival into functional recovery worldwide. |
| format | Article |
| id | doaj-art-e8f3058ecda9469ca9f24d9d07efc761 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-e8f3058ecda9469ca9f24d9d07efc7612025-08-20T03:31:20ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-07-011610.3389/fneur.2025.16241011624101Global collaboration and innovation in malignant cerebral edema research: a bibliometric perspectiveXinhua Peng0Xinhua Peng1Rongrong Zhu2Ke Zhang3Jianghong Ji4Chuanguo Lv5Feng Feng6Feng Feng7Medical School of Nantong University, Nantong, ChinaImaging Department, Qidong People’s Hospital, Qidong Liver Cancer Institute, Affiliated Qidong Hospital of Nantong University, Qidong, ChinaImaging Department, Qidong People’s Hospital, Qidong Liver Cancer Institute, Affiliated Qidong Hospital of Nantong University, Qidong, ChinaImaging Department, Qidong People’s Hospital, Qidong Liver Cancer Institute, Affiliated Qidong Hospital of Nantong University, Qidong, ChinaImaging Department, Qidong People’s Hospital, Qidong Liver Cancer Institute, Affiliated Qidong Hospital of Nantong University, Qidong, ChinaImaging Department, Qidong People’s Hospital, Qidong Liver Cancer Institute, Affiliated Qidong Hospital of Nantong University, Qidong, ChinaMedical School of Nantong University, Nantong, ChinaDepartment of Radiology, Affiliated Tumor Hospital of Nantong University, Nantong, ChinaAimMalignant cerebral edema (MCE) is a life-threatening complication of acute brain injuries, with mortality rates exceeding 80% in the absence of treatment. Despite advancements in osmotic therapies and decompressive craniectomy (DC), MCE continues to pose substantial clinical challenges. This study systematically maps the evolution of MCE research (2005–2024) to identify key trends, research gaps, and future priorities.MethodsA bibliometric analysis of 1,460 peer-reviewed articles from the Web of Science Core Collection was conducted using CiteSpace, VOSviewer, and Bibliometrix. Key metrics included publication trends, geographic and institutional contributions, keyword co-occurrence, citation networks, and co-authorship patterns.ResultsAnnual publications increased from 55 in 2005 to 128 in 2024, progressing through three distinct phases: Foundational growth (2005–2009), consolidation (2010–2014), and rapid expansion (2015–2024). The United States (28.9%) and China (18.7%) dominated research output, with Harvard University and the University of California System leading institutional collaboration clusters. High-impact journals highlighted clinical advancements, including Stroke (h-index = 27). Keyword analysis demonstrated a thematic progression from blood–brain barrier pathophysiology to clinical innovations, including DC and emerging predictive modeling techniques incorporating machine learning. Landmark trials, including DECIMAL and HAMLET, validated early surgical intervention, while emerging trends have emphasized precision medicine and artificial intelligence (AI)-driven risk stratification.ConclusionThe MCE research has transitioned from foundational pathophysiology to interdisciplinary clinical practice and data integration. However, critical gaps remain, including underrepresentation in pediatric research, disparities in global neurocritical care, and challenges in translational application. Future priorities should focus on biomarker discovery, equitable global collaborations, and AI-enhanced frameworks to transform survival into functional recovery worldwide.https://www.frontiersin.org/articles/10.3389/fneur.2025.1624101/fullmalignant cerebral edemadecompressive craniectomycytotoxic edemablood–brain barrierneurocritical carebibliometric analysis |
| spellingShingle | Xinhua Peng Xinhua Peng Rongrong Zhu Ke Zhang Jianghong Ji Chuanguo Lv Feng Feng Feng Feng Global collaboration and innovation in malignant cerebral edema research: a bibliometric perspective Frontiers in Neurology malignant cerebral edema decompressive craniectomy cytotoxic edema blood–brain barrier neurocritical care bibliometric analysis |
| title | Global collaboration and innovation in malignant cerebral edema research: a bibliometric perspective |
| title_full | Global collaboration and innovation in malignant cerebral edema research: a bibliometric perspective |
| title_fullStr | Global collaboration and innovation in malignant cerebral edema research: a bibliometric perspective |
| title_full_unstemmed | Global collaboration and innovation in malignant cerebral edema research: a bibliometric perspective |
| title_short | Global collaboration and innovation in malignant cerebral edema research: a bibliometric perspective |
| title_sort | global collaboration and innovation in malignant cerebral edema research a bibliometric perspective |
| topic | malignant cerebral edema decompressive craniectomy cytotoxic edema blood–brain barrier neurocritical care bibliometric analysis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1624101/full |
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