Characteristics of physical and chemical properties, antioxidant, antimutagenic and reparative activity of nanocomplexes of curcuminoids with cyclodextrins
The spectral properties and thermal stability of cyclodextrins:curcuminoids nanocomplexes were characterized by the use of the methods of IR spectroscopy and thermal analysis. The changes in the activation energy of thermal destruction of curcuminoids during the formation of nanocomplexes were calcu...
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| Format: | Article |
| Language: | Russian |
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North-Caucasus Federal University
2024-05-01
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| Series: | Современная наука и инновации |
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| Online Access: | https://msi.elpub.ru/jour/article/view/1595 |
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| author | M. A. Kapustin A. S. Chubarova I. V. Rzhepakovsky S. I. Piskov I. A. Evdokimov A. D. Lodygin V. G. Cigankov N. V. Dudchik A. V. Adamovich V. P. Kurchenko |
| author_facet | M. A. Kapustin A. S. Chubarova I. V. Rzhepakovsky S. I. Piskov I. A. Evdokimov A. D. Lodygin V. G. Cigankov N. V. Dudchik A. V. Adamovich V. P. Kurchenko |
| author_sort | M. A. Kapustin |
| collection | DOAJ |
| description | The spectral properties and thermal stability of cyclodextrins:curcuminoids nanocomplexes were characterized by the use of the methods of IR spectroscopy and thermal analysis. The changes in the activation energy of thermal destruction of curcuminoids during the formation of nanocomplexes were calculated. In the model system for the reduction of the radical cation ABTS˙+, IC50 values were determined for nanocomplexes of curcuminoids with β-cyclodextrin (Curc:β-CD) and 2-hydroxypropyl-beta-cyclodextrin (Curc:HP-β-CD), obtained by co-evaporation and lyophilization at a ratio of 1:2, which were 1.076 g/L and 0.161 g/L, respectively. Using the Ames test, the presence of antimutagenic activity of the drugs Curc:β-CD and Curc:HP-β-CD was demonstrated. When Curc:HP-β-CD 1:2 nanocomplexes were added to the incubation medium of the drug, a significant decrease in the frequency of mutagenesis was observed by 50% compared to the control. The use of Curc:β-CD 1:2 nanocomplexes as a wound-healing agent on a skin patch wound model in Wistar rats showed the course of the regenerative process along the path of organotypic regeneration. |
| format | Article |
| id | doaj-art-e8ee79d2a4cf43dfb15f403463d4ed28 |
| institution | Kabale University |
| issn | 2307-910X |
| language | Russian |
| publishDate | 2024-05-01 |
| publisher | North-Caucasus Federal University |
| record_format | Article |
| series | Современная наука и инновации |
| spelling | doaj-art-e8ee79d2a4cf43dfb15f403463d4ed282025-08-20T03:57:48ZrusNorth-Caucasus Federal UniversityСовременная наука и инновации2307-910X2024-05-0101809610.37493/2307-910X.2024.1.81562Characteristics of physical and chemical properties, antioxidant, antimutagenic and reparative activity of nanocomplexes of curcuminoids with cyclodextrinsM. A. Kapustin0A. S. Chubarova1I. V. Rzhepakovsky2S. I. Piskov3I. A. Evdokimov4A. D. Lodygin5V. G. Cigankov6N. V. Dudchik7A. V. Adamovich8V. P. Kurchenko9Belorussian State University; North-Caucasus Federal UniversityBelarusian State UniversityNorth-Caucasus Federal UniversityNorth-Caucasus Federal UniversityNorth-Caucasus Federal UniversityNorth-Caucasus Federal UniversityScientific and Practical Center for HygieneScientific and Practical Center for HygieneScientific and Practical Center for HygieneBelorussian State University; North-Caucasus Federal UniversityThe spectral properties and thermal stability of cyclodextrins:curcuminoids nanocomplexes were characterized by the use of the methods of IR spectroscopy and thermal analysis. The changes in the activation energy of thermal destruction of curcuminoids during the formation of nanocomplexes were calculated. In the model system for the reduction of the radical cation ABTS˙+, IC50 values were determined for nanocomplexes of curcuminoids with β-cyclodextrin (Curc:β-CD) and 2-hydroxypropyl-beta-cyclodextrin (Curc:HP-β-CD), obtained by co-evaporation and lyophilization at a ratio of 1:2, which were 1.076 g/L and 0.161 g/L, respectively. Using the Ames test, the presence of antimutagenic activity of the drugs Curc:β-CD and Curc:HP-β-CD was demonstrated. When Curc:HP-β-CD 1:2 nanocomplexes were added to the incubation medium of the drug, a significant decrease in the frequency of mutagenesis was observed by 50% compared to the control. The use of Curc:β-CD 1:2 nanocomplexes as a wound-healing agent on a skin patch wound model in Wistar rats showed the course of the regenerative process along the path of organotypic regeneration.https://msi.elpub.ru/jour/article/view/1595ir-spectroscopythermal analisisβ-cyclodextrinhp-β-cyclodextrincurcuminoidsnanocomplexesnanostructuresanimutagenesantioxidantswound healing |
| spellingShingle | M. A. Kapustin A. S. Chubarova I. V. Rzhepakovsky S. I. Piskov I. A. Evdokimov A. D. Lodygin V. G. Cigankov N. V. Dudchik A. V. Adamovich V. P. Kurchenko Characteristics of physical and chemical properties, antioxidant, antimutagenic and reparative activity of nanocomplexes of curcuminoids with cyclodextrins Современная наука и инновации ir-spectroscopy thermal analisis β-cyclodextrin hp-β-cyclodextrin curcuminoids nanocomplexes nanostructures animutagenes antioxidants wound healing |
| title | Characteristics of physical and chemical properties, antioxidant, antimutagenic and reparative activity of nanocomplexes of curcuminoids with cyclodextrins |
| title_full | Characteristics of physical and chemical properties, antioxidant, antimutagenic and reparative activity of nanocomplexes of curcuminoids with cyclodextrins |
| title_fullStr | Characteristics of physical and chemical properties, antioxidant, antimutagenic and reparative activity of nanocomplexes of curcuminoids with cyclodextrins |
| title_full_unstemmed | Characteristics of physical and chemical properties, antioxidant, antimutagenic and reparative activity of nanocomplexes of curcuminoids with cyclodextrins |
| title_short | Characteristics of physical and chemical properties, antioxidant, antimutagenic and reparative activity of nanocomplexes of curcuminoids with cyclodextrins |
| title_sort | characteristics of physical and chemical properties antioxidant antimutagenic and reparative activity of nanocomplexes of curcuminoids with cyclodextrins |
| topic | ir-spectroscopy thermal analisis β-cyclodextrin hp-β-cyclodextrin curcuminoids nanocomplexes nanostructures animutagenes antioxidants wound healing |
| url | https://msi.elpub.ru/jour/article/view/1595 |
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