Biological Function and Mechanism of NAT10 in Cancer
Abstract N‐acetyltransferase 10 (NAT10) is a nucleolar acetyltransferase with an acetylation catalytic function and can bind various protein and RNA molecules. As the N4‐acetylcytidine (ac4C) “writer” enzyme, NAT10 is reportedly involved in a variety of physiological and pathological activities. Cur...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Cancer Innovation |
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| Online Access: | https://doi.org/10.1002/cai2.154 |
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| _version_ | 1849727567922200576 |
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| author | Yufeng Han Xinxin Zhang Lei Miao Huiran Lin Zhenjian Zhuo Jing He Wen Fu |
| author_facet | Yufeng Han Xinxin Zhang Lei Miao Huiran Lin Zhenjian Zhuo Jing He Wen Fu |
| author_sort | Yufeng Han |
| collection | DOAJ |
| description | Abstract N‐acetyltransferase 10 (NAT10) is a nucleolar acetyltransferase with an acetylation catalytic function and can bind various protein and RNA molecules. As the N4‐acetylcytidine (ac4C) “writer” enzyme, NAT10 is reportedly involved in a variety of physiological and pathological activities. Currently, the NAT10‐related molecular mechanisms in various cancers are not fully understood. In this review, we first describe the cellular localization of NAT10 and then summarize its numerous biological functions. NAT10 is involved in various biological processes by mediating the acetylation of different proteins and RNAs. These biological functions are also associated with cancer progression and patient prognosis. We also review the mechanisms by which NAT10 plays roles in various cancer types. NAT10 can affect tumor cell proliferation, metastasis, and stress tolerance through its acetyltransferase properties. Further research into NAT10 functions and expression regulation in tumors will help explore its future potential in cancer diagnosis, treatment, and prognosis. |
| format | Article |
| id | doaj-art-e8eb5aaa3d5c4980a8d07900110be29a |
| institution | DOAJ |
| issn | 2770-9191 2770-9183 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Innovation |
| spelling | doaj-art-e8eb5aaa3d5c4980a8d07900110be29a2025-08-20T03:09:48ZengWileyCancer Innovation2770-91912770-91832025-02-0141n/an/a10.1002/cai2.154Biological Function and Mechanism of NAT10 in CancerYufeng Han0Xinxin Zhang1Lei Miao2Huiran Lin3Zhenjian Zhuo4Jing He5Wen Fu6Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics Guangzhou Medical University Guangzhou Guangdong ChinaGuangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics Guangzhou Medical University Guangzhou Guangdong ChinaGuangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics Guangzhou Medical University Guangzhou Guangdong ChinaFaculty of Medicine Macau University of Science and Technology Macau ChinaLaboratory Animal Center, School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen Guangdong ChinaGuangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics Guangzhou Medical University Guangzhou Guangdong ChinaGuangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics Guangzhou Medical University Guangzhou Guangdong ChinaAbstract N‐acetyltransferase 10 (NAT10) is a nucleolar acetyltransferase with an acetylation catalytic function and can bind various protein and RNA molecules. As the N4‐acetylcytidine (ac4C) “writer” enzyme, NAT10 is reportedly involved in a variety of physiological and pathological activities. Currently, the NAT10‐related molecular mechanisms in various cancers are not fully understood. In this review, we first describe the cellular localization of NAT10 and then summarize its numerous biological functions. NAT10 is involved in various biological processes by mediating the acetylation of different proteins and RNAs. These biological functions are also associated with cancer progression and patient prognosis. We also review the mechanisms by which NAT10 plays roles in various cancer types. NAT10 can affect tumor cell proliferation, metastasis, and stress tolerance through its acetyltransferase properties. Further research into NAT10 functions and expression regulation in tumors will help explore its future potential in cancer diagnosis, treatment, and prognosis.https://doi.org/10.1002/cai2.154acetyltransferasecancerN‐acetyltransferase 10N4‐acetylcytidine |
| spellingShingle | Yufeng Han Xinxin Zhang Lei Miao Huiran Lin Zhenjian Zhuo Jing He Wen Fu Biological Function and Mechanism of NAT10 in Cancer Cancer Innovation acetyltransferase cancer N‐acetyltransferase 10 N4‐acetylcytidine |
| title | Biological Function and Mechanism of NAT10 in Cancer |
| title_full | Biological Function and Mechanism of NAT10 in Cancer |
| title_fullStr | Biological Function and Mechanism of NAT10 in Cancer |
| title_full_unstemmed | Biological Function and Mechanism of NAT10 in Cancer |
| title_short | Biological Function and Mechanism of NAT10 in Cancer |
| title_sort | biological function and mechanism of nat10 in cancer |
| topic | acetyltransferase cancer N‐acetyltransferase 10 N4‐acetylcytidine |
| url | https://doi.org/10.1002/cai2.154 |
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