A long-term stable cold-chain-friendly HIV mRNA vaccine encoding multi-epitope viral protease cleavage site immunogens inducing immunogen-specific protective T cell immunity

A long-term stable cold-chain-friendly HIV mRNA vaccine encoding multi-epitope viral protease cleavage site immunogens inducing immunogen-specific protective T cell immunity

The lack of success in clinical trials for HIV vaccines highlights the need to explore novel strategies for vaccine development. Research on highly exposed seronegative (HESN) HIV-resistant Kenyan female sex workers revealed naturally protective immunity is correlated with a focused immune response...

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Bibliographic Details
Main Authors: Subhra Mandal, Jayadri Sekhar Ghosh, Saroj Chandra Lohani, Miaoyun Zhao, Yilun Cheng, Rachel Burrack, Ma Luo, Qingsheng Li
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
HIV vaccine
prophylaxis
cold-chain friendly mRNA LNPs
protective immunity
multi-epitope viral PCS
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2377606
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