Acute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study
IntroductionAnimal studies have suggested that Lion’s Mane mushroom [Hericium erinaceus (Bull.) Pers.] can enhance cognitive function and mood due to its bioactive metabolites, including erinacines and hericenones. However, despite being an ingredient used both culinarily and therapeutically in the...
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Frontiers Media S.A.
2025-04-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1405796/full |
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| author | Geyan Surendran Jake Saye Syahira Binti Mohd Jalil Jack Spreadborough Kyle Duong Israa M. Shatwan Dash Lilley Michael Heinrich Michael Heinrich Georgina F. Dodd Shelini Surendran |
| author_facet | Geyan Surendran Jake Saye Syahira Binti Mohd Jalil Jack Spreadborough Kyle Duong Israa M. Shatwan Dash Lilley Michael Heinrich Michael Heinrich Georgina F. Dodd Shelini Surendran |
| author_sort | Geyan Surendran |
| collection | DOAJ |
| description | IntroductionAnimal studies have suggested that Lion’s Mane mushroom [Hericium erinaceus (Bull.) Pers.] can enhance cognitive function and mood due to its bioactive metabolites, including erinacines and hericenones. However, despite being an ingredient used both culinarily and therapeutically in the East, and more and more commonly in the West, limited research has focused on the immediate effects of H. erinaceus on the cognitive function and mood of healthy young adults.MethodsIn an acute randomized, placebo-controlled, double-blinded, cross-over intervention study, we investigated the potential benefits of an acute dose of H. erinaceus fruiting body extract (3g of 10:1 extract) on cognitive performance and mood compared to a placebo. Eighteen healthy participants aged 18 to 35 years took part in the study. At baseline and 90 minutes post-consumption of the interventions, cognitive and mood assessments were administered to measure various cognitive abilities such as executive function, working memory, psychomotor skills, attention and information processing speed as well as positive and negative affect.Results and discussionThe results showed no significant effect of the H. erinaceus fruiting body extract for composite measures of global cognitive function and mood. However, when analysing individual tests, participants exhibited improved performance on the pegboard test at 90 minutes following a single dose of H. erinaceus.ConclusionIn conclusion, acute consumption of H. erinaceus fruiting body did not demonstrate a significant overall improvement in cognitive performance and mood compared to the placebo and any benefits may be task or domain specific. Further investigations should investigate the effects of chronic supplementation of H. erinaceus fruiting body on cognition and mood in healthy younger adults, as well as establish optimal dosage and the time to peak concentration of H. erinaceus bioactives in the human brain. Additionally, future research should aim to further elucidate potential mechanisms of action to explain potential brain region and cognitive domain specific effects, such as possible regional increases in cerebral blood flow following consumption of H. erinaceus fruiting bodies. It must also be noted that typically only Lion’s mane fruiting bodies are consumed culinarily, where up to 300g of fresh fruiting body are often consumed in the form of mushroom steaks. |
| format | Article |
| id | doaj-art-e8e60fd57bca46fbaa1eca925c10a295 |
| institution | DOAJ |
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| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-e8e60fd57bca46fbaa1eca925c10a2952025-08-20T03:09:07ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-04-011210.3389/fnut.2025.14057961405796Acute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled studyGeyan Surendran0Jake Saye1Syahira Binti Mohd Jalil2Jack Spreadborough3Kyle Duong4Israa M. Shatwan5Dash Lilley6Michael Heinrich7Michael Heinrich8Georgina F. Dodd9Shelini Surendran10Beyond Alcohol Ltd., London, United KingdomFaculty of Health and Medical Sciences, University of Surrey, Guildford, United KingdomFaculty of Health and Medical Sciences, University of Surrey, Guildford, United KingdomFaculty of Health and Medical Sciences, University of Surrey, Guildford, United KingdomFaculty of Health and Medical Sciences, University of Surrey, Guildford, United KingdomFood and Nutrition Department, Human Sciences and Design Faculty, King Abdulaziz University, Jeddah, Saudi ArabiaBeyond Alcohol Ltd., London, United KingdomPharmacognosy and Phytotherapy, UCL School of Pharmacy, London, United KingdomGraduate Institute of Integrated Medicine, College of Chinese Medicine, Chinese Medicine Research Center, China Medical University, Taichung, TaiwanClasado Ltd, Imperium Building, Imperial Way, Worton Grange, Reading, Berkshire, United KingdomFaculty of Health and Medical Sciences, University of Surrey, Guildford, United KingdomIntroductionAnimal studies have suggested that Lion’s Mane mushroom [Hericium erinaceus (Bull.) Pers.] can enhance cognitive function and mood due to its bioactive metabolites, including erinacines and hericenones. However, despite being an ingredient used both culinarily and therapeutically in the East, and more and more commonly in the West, limited research has focused on the immediate effects of H. erinaceus on the cognitive function and mood of healthy young adults.MethodsIn an acute randomized, placebo-controlled, double-blinded, cross-over intervention study, we investigated the potential benefits of an acute dose of H. erinaceus fruiting body extract (3g of 10:1 extract) on cognitive performance and mood compared to a placebo. Eighteen healthy participants aged 18 to 35 years took part in the study. At baseline and 90 minutes post-consumption of the interventions, cognitive and mood assessments were administered to measure various cognitive abilities such as executive function, working memory, psychomotor skills, attention and information processing speed as well as positive and negative affect.Results and discussionThe results showed no significant effect of the H. erinaceus fruiting body extract for composite measures of global cognitive function and mood. However, when analysing individual tests, participants exhibited improved performance on the pegboard test at 90 minutes following a single dose of H. erinaceus.ConclusionIn conclusion, acute consumption of H. erinaceus fruiting body did not demonstrate a significant overall improvement in cognitive performance and mood compared to the placebo and any benefits may be task or domain specific. Further investigations should investigate the effects of chronic supplementation of H. erinaceus fruiting body on cognition and mood in healthy younger adults, as well as establish optimal dosage and the time to peak concentration of H. erinaceus bioactives in the human brain. Additionally, future research should aim to further elucidate potential mechanisms of action to explain potential brain region and cognitive domain specific effects, such as possible regional increases in cerebral blood flow following consumption of H. erinaceus fruiting bodies. It must also be noted that typically only Lion’s mane fruiting bodies are consumed culinarily, where up to 300g of fresh fruiting body are often consumed in the form of mushroom steaks.https://www.frontiersin.org/articles/10.3389/fnut.2025.1405796/fullmushroomLion’s Mane mushroomHericium erinaceuscognitionmood |
| spellingShingle | Geyan Surendran Jake Saye Syahira Binti Mohd Jalil Jack Spreadborough Kyle Duong Israa M. Shatwan Dash Lilley Michael Heinrich Michael Heinrich Georgina F. Dodd Shelini Surendran Acute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study Frontiers in Nutrition mushroom Lion’s Mane mushroom Hericium erinaceus cognition mood |
| title | Acute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study |
| title_full | Acute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study |
| title_fullStr | Acute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study |
| title_full_unstemmed | Acute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study |
| title_short | Acute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study |
| title_sort | acute effects of a standardised extract of hericium erinaceus lion s mane mushroom on cognition and mood in healthy younger adults a double blind randomised placebo controlled study |
| topic | mushroom Lion’s Mane mushroom Hericium erinaceus cognition mood |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1405796/full |
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