Domain‐Specific and Domain‐General Functional Brain Alterations in Type 2 Diabetes Mellitus: A Task‐Based and Functional Connectivity Meta‐Analysis
ABSTRACT Introduction Patients with Type 2 diabetes experience cognitive and affective deficits linked to widespread functional brain alterations. However, previous meta‐analyses of functional neuroimaging have primarily focused on the resting‐state studies. While valuable, this approach may have ov...
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Wiley
2025-04-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70438 |
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| author | Valentino Marcel Tahamata Yang‐Teng Fan Li Wei Yen‐Nung Lin Roger Marcelo Martinez Kah Kheng Goh Yu‐Chun Chen Chenyi Chen |
| author_facet | Valentino Marcel Tahamata Yang‐Teng Fan Li Wei Yen‐Nung Lin Roger Marcelo Martinez Kah Kheng Goh Yu‐Chun Chen Chenyi Chen |
| author_sort | Valentino Marcel Tahamata |
| collection | DOAJ |
| description | ABSTRACT Introduction Patients with Type 2 diabetes experience cognitive and affective deficits linked to widespread functional brain alterations. However, previous meta‐analyses of functional neuroimaging have primarily focused on the resting‐state studies. While valuable, this approach may have overlooked the key neuronal mechanisms underlying these deficits. Methods To address this, we conducted a coordinate‐level task‐based meta‐analysis of functional neuroimaging via a systematic search of Embase, PubMed, Medline, and Web of Science (December 2023), alongside task‐based and task‐free connectivity analyses using the BrainMap database. Activation likelihood estimations were applied to two task categories: that are, cognitive and affective. To control for biased results, we also conducted jackknife sensitivity analysis and within‐paper combined experiments analysis as validation analyses. Results We identified a cluster of activation in cognitive paradigm (18 contrasts, 153 foci, 767 subjects), with the middle frontal gyrus, part of the medial frontal cortex, as the peak region. For the affective paradigm (18 contrasts, 181 foci, 951 subjects), we observed both increased and decreased activities. Two increased clusters peak in the amygdala and middle temporal gyrus, while the three decreased clusters were inferior frontal gyrus, insula, and putamen. Follow‐up connectivity analyses showed that these brain alterations were both task‐specific and task‐generic. Conclusion Despite the lack of uniformity across task, such domain‐specific and domain‐general patterns of alterations provide a more nuanced understanding of the cognitive and affective deficits in Type 2 diabetes patients. This highlights the varied neuronal mechanisms underlying these deficits. |
| format | Article |
| id | doaj-art-e8e5ee4ae778488394e90675fc4bd49a |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
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| series | Brain and Behavior |
| spelling | doaj-art-e8e5ee4ae778488394e90675fc4bd49a2025-08-20T03:53:41ZengWileyBrain and Behavior2162-32792025-04-01154n/an/a10.1002/brb3.70438Domain‐Specific and Domain‐General Functional Brain Alterations in Type 2 Diabetes Mellitus: A Task‐Based and Functional Connectivity Meta‐AnalysisValentino Marcel Tahamata0Yang‐Teng Fan1Li Wei2Yen‐Nung Lin3Roger Marcelo Martinez4Kah Kheng Goh5Yu‐Chun Chen6Chenyi Chen7Graduate Institute of Mind, Brain and Consciousness College of Humanities and Social Sciences Taipei TaiwanGraduate Institute of Medicine Yuan Ze University Taoyuan TaiwanGraduate Institute of Injury Prevention and Control, College of Public Health Taipei Medical University Taipei TaiwanGraduate Institute of Injury Prevention and Control, College of Public Health Taipei Medical University Taipei TaiwanGraduate Institute of Injury Prevention and Control, College of Public Health Taipei Medical University Taipei TaiwanGraduate Institute of Injury Prevention and Control, College of Public Health Taipei Medical University Taipei TaiwanDepartment of Physical Education National Taiwan University of Sport Taichung TaiwanGraduate Institute of Mind, Brain and Consciousness College of Humanities and Social Sciences Taipei TaiwanABSTRACT Introduction Patients with Type 2 diabetes experience cognitive and affective deficits linked to widespread functional brain alterations. However, previous meta‐analyses of functional neuroimaging have primarily focused on the resting‐state studies. While valuable, this approach may have overlooked the key neuronal mechanisms underlying these deficits. Methods To address this, we conducted a coordinate‐level task‐based meta‐analysis of functional neuroimaging via a systematic search of Embase, PubMed, Medline, and Web of Science (December 2023), alongside task‐based and task‐free connectivity analyses using the BrainMap database. Activation likelihood estimations were applied to two task categories: that are, cognitive and affective. To control for biased results, we also conducted jackknife sensitivity analysis and within‐paper combined experiments analysis as validation analyses. Results We identified a cluster of activation in cognitive paradigm (18 contrasts, 153 foci, 767 subjects), with the middle frontal gyrus, part of the medial frontal cortex, as the peak region. For the affective paradigm (18 contrasts, 181 foci, 951 subjects), we observed both increased and decreased activities. Two increased clusters peak in the amygdala and middle temporal gyrus, while the three decreased clusters were inferior frontal gyrus, insula, and putamen. Follow‐up connectivity analyses showed that these brain alterations were both task‐specific and task‐generic. Conclusion Despite the lack of uniformity across task, such domain‐specific and domain‐general patterns of alterations provide a more nuanced understanding of the cognitive and affective deficits in Type 2 diabetes patients. This highlights the varied neuronal mechanisms underlying these deficits.https://doi.org/10.1002/brb3.70438functional decodingneuroimaging meta‐analysisresting‐state functional connectivityType 2 diabetes mellitus |
| spellingShingle | Valentino Marcel Tahamata Yang‐Teng Fan Li Wei Yen‐Nung Lin Roger Marcelo Martinez Kah Kheng Goh Yu‐Chun Chen Chenyi Chen Domain‐Specific and Domain‐General Functional Brain Alterations in Type 2 Diabetes Mellitus: A Task‐Based and Functional Connectivity Meta‐Analysis Brain and Behavior functional decoding neuroimaging meta‐analysis resting‐state functional connectivity Type 2 diabetes mellitus |
| title | Domain‐Specific and Domain‐General Functional Brain Alterations in Type 2 Diabetes Mellitus: A Task‐Based and Functional Connectivity Meta‐Analysis |
| title_full | Domain‐Specific and Domain‐General Functional Brain Alterations in Type 2 Diabetes Mellitus: A Task‐Based and Functional Connectivity Meta‐Analysis |
| title_fullStr | Domain‐Specific and Domain‐General Functional Brain Alterations in Type 2 Diabetes Mellitus: A Task‐Based and Functional Connectivity Meta‐Analysis |
| title_full_unstemmed | Domain‐Specific and Domain‐General Functional Brain Alterations in Type 2 Diabetes Mellitus: A Task‐Based and Functional Connectivity Meta‐Analysis |
| title_short | Domain‐Specific and Domain‐General Functional Brain Alterations in Type 2 Diabetes Mellitus: A Task‐Based and Functional Connectivity Meta‐Analysis |
| title_sort | domain specific and domain general functional brain alterations in type 2 diabetes mellitus a task based and functional connectivity meta analysis |
| topic | functional decoding neuroimaging meta‐analysis resting‐state functional connectivity Type 2 diabetes mellitus |
| url | https://doi.org/10.1002/brb3.70438 |
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