Procalcitonin as a Diagnostic and Monitoring Tool for Bacteraemia in Patients on Haemodialysis: A Systematic Review
Background: Infections are a major cause of mortality in haemodialysis patients. The increasing antimicrobial resistance globally further exacerbates this concern. Procalcitonin has shown potential in aiding antimicrobial stewardship and reducing the mortality and morbidity associated with infection...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Kidney and Dialysis |
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| Online Access: | https://www.mdpi.com/2673-8236/5/2/24 |
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| author | Aniebiot-Abasi Udofia Yiwei Zhang |
| author_facet | Aniebiot-Abasi Udofia Yiwei Zhang |
| author_sort | Aniebiot-Abasi Udofia |
| collection | DOAJ |
| description | Background: Infections are a major cause of mortality in haemodialysis patients. The increasing antimicrobial resistance globally further exacerbates this concern. Procalcitonin has shown potential in aiding antimicrobial stewardship and reducing the mortality and morbidity associated with infections. This systematic review aims to synthesise the existing literature on the utility of procalcitonin as a diagnostic and monitoring tool for haemodialysis patients with suspected bacteraemia. Methods: Multiple electronic databases (EMBASE, MEDLINE, and the Cochrane Library) were systematically searched to identify primary studies evaluating procalcitonin use in haemodialysis patients with suspected bacteraemia. Using a narrative synthesis approach, along with other quality assessment tools, recommendations regarding procalcitonin usage in dialysis were formulated. Results: Eleven studies were identified. The review proposes a procalcitonin-guided antibiotic protocol aimed at facilitating antibiotic use in haemodialysis patients with suspected bacteraemia. Caution is, however, advised against relying solely on procalcitonin for diagnosis, emphasising the integration of procalcitonin with other clinical and biomarkers of infection. Conclusions: Procalcitonin shows promise as a valuable diagnostic and monitoring tool for suspected bacteraemia in haemodialysis patients. While caution is advised against relying solely on PCT for diagnosis, its integration with other clinical indicators can enhance infection management. To fully establish its clinical utility, more research is needed. |
| format | Article |
| id | doaj-art-e8e5cb3392d240e4a60487673fb949ce |
| institution | Kabale University |
| issn | 2673-8236 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Kidney and Dialysis |
| spelling | doaj-art-e8e5cb3392d240e4a60487673fb949ce2025-08-20T03:27:29ZengMDPI AGKidney and Dialysis2673-82362025-06-01522410.3390/kidneydial5020024Procalcitonin as a Diagnostic and Monitoring Tool for Bacteraemia in Patients on Haemodialysis: A Systematic ReviewAniebiot-Abasi Udofia0Yiwei Zhang1Department of Nephrology, University Hospital of Leicester NHS Trust, Leicester LE5 4PW, UKFaculty of Life Sciences and Education, University of South Wales, Wales CF24 0AA, UKBackground: Infections are a major cause of mortality in haemodialysis patients. The increasing antimicrobial resistance globally further exacerbates this concern. Procalcitonin has shown potential in aiding antimicrobial stewardship and reducing the mortality and morbidity associated with infections. This systematic review aims to synthesise the existing literature on the utility of procalcitonin as a diagnostic and monitoring tool for haemodialysis patients with suspected bacteraemia. Methods: Multiple electronic databases (EMBASE, MEDLINE, and the Cochrane Library) were systematically searched to identify primary studies evaluating procalcitonin use in haemodialysis patients with suspected bacteraemia. Using a narrative synthesis approach, along with other quality assessment tools, recommendations regarding procalcitonin usage in dialysis were formulated. Results: Eleven studies were identified. The review proposes a procalcitonin-guided antibiotic protocol aimed at facilitating antibiotic use in haemodialysis patients with suspected bacteraemia. Caution is, however, advised against relying solely on procalcitonin for diagnosis, emphasising the integration of procalcitonin with other clinical and biomarkers of infection. Conclusions: Procalcitonin shows promise as a valuable diagnostic and monitoring tool for suspected bacteraemia in haemodialysis patients. While caution is advised against relying solely on PCT for diagnosis, its integration with other clinical indicators can enhance infection management. To fully establish its clinical utility, more research is needed.https://www.mdpi.com/2673-8236/5/2/24bacteraemiahaemodialysisprocalcitoninrenal replacement therapysepsis |
| spellingShingle | Aniebiot-Abasi Udofia Yiwei Zhang Procalcitonin as a Diagnostic and Monitoring Tool for Bacteraemia in Patients on Haemodialysis: A Systematic Review Kidney and Dialysis bacteraemia haemodialysis procalcitonin renal replacement therapy sepsis |
| title | Procalcitonin as a Diagnostic and Monitoring Tool for Bacteraemia in Patients on Haemodialysis: A Systematic Review |
| title_full | Procalcitonin as a Diagnostic and Monitoring Tool for Bacteraemia in Patients on Haemodialysis: A Systematic Review |
| title_fullStr | Procalcitonin as a Diagnostic and Monitoring Tool for Bacteraemia in Patients on Haemodialysis: A Systematic Review |
| title_full_unstemmed | Procalcitonin as a Diagnostic and Monitoring Tool for Bacteraemia in Patients on Haemodialysis: A Systematic Review |
| title_short | Procalcitonin as a Diagnostic and Monitoring Tool for Bacteraemia in Patients on Haemodialysis: A Systematic Review |
| title_sort | procalcitonin as a diagnostic and monitoring tool for bacteraemia in patients on haemodialysis a systematic review |
| topic | bacteraemia haemodialysis procalcitonin renal replacement therapy sepsis |
| url | https://www.mdpi.com/2673-8236/5/2/24 |
| work_keys_str_mv | AT aniebiotabasiudofia procalcitoninasadiagnosticandmonitoringtoolforbacteraemiainpatientsonhaemodialysisasystematicreview AT yiweizhang procalcitoninasadiagnosticandmonitoringtoolforbacteraemiainpatientsonhaemodialysisasystematicreview |