Leaf-vein-inspired multi-organ microfluidic chip for modeling breast cancer CTC organotropism

Leaf-vein-inspired multi-organ microfluidic chip for modeling breast cancer CTC organotropism

ObjectiveBreast cancer is characterized by a high tendency for organ-specific metastasis. This study aims to develop a multi-organ metastasis model for circulating tumor cells (CTCs) of breast cancer to explore their organotropism in common target organs, including the liver, bone, and lung.MethodsW...

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Bibliographic Details
Main Authors: Liuyin Liu, Xiaoli Qu, Zhe Wang, Cheng Ji, Rui Ling, Changjiao Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
breast cancer
circulating tumor cell
leaf vein architecture
multi-organ microfluidic chip
organotropism
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1602225/full
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