Flow Resistance Analysis of Clinically Significant Portal Hypertension in Patients with Liver Cirrhosis
Cirrhosis-induced clinically significant portal hypertension (CSPH) is a fatal disease. Early detection of CSPH is vitally important to reduce the patients’ mortality rate. In this study, combined with three-dimensional image construction technology and computational fluid dynamics (CFD), an image-b...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2022/9396371 |
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| _version_ | 1849690951965999104 |
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| author | Yizhe Wang Luxiang Zhao Zhuozhao Zheng Yu Zhang |
| author_facet | Yizhe Wang Luxiang Zhao Zhuozhao Zheng Yu Zhang |
| author_sort | Yizhe Wang |
| collection | DOAJ |
| description | Cirrhosis-induced clinically significant portal hypertension (CSPH) is a fatal disease. Early detection of CSPH is vitally important to reduce the patients’ mortality rate. In this study, combined with three-dimensional image construction technology and computational fluid dynamics (CFD), an image-based flow resistance analysis was proposed. The flow resistance analysis was performed for nine cirrhosis patients with CSPH and ten participants without liver diseases, respectively. The results showed that the flow resistance coefficient of the portal vein system in CSPH patients was significantly lower than that in the control group (0.97 ± 0.11 Pa/(mL/s) for CSPH patients; 1.80 ± 0.40 Pa/(mL/s) for the control group; P=0.028). In contrast, although main portal vein dilation was found in CSPH patients, the cross-sectional area enlargement was not statistically significant (186.01 ± 57.48 mm2 for CSPH patients; 166.26 ± 33.74 mm2 for the control group; P=0.39). The research outcomes indicated that the flow resistance analysis was more sensitive than the commonly used vessel size measurement in the detection of CSPH. In summary, we suggest using flow resistance analysis as a supplementary noninvasive method to detect cirrhosis patients with CSPH. |
| format | Article |
| id | doaj-art-e8dfe9e00eab4848925dd63c10eb783d |
| institution | DOAJ |
| issn | 2291-2797 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-e8dfe9e00eab4848925dd63c10eb783d2025-08-20T03:21:10ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27972022-01-01202210.1155/2022/9396371Flow Resistance Analysis of Clinically Significant Portal Hypertension in Patients with Liver CirrhosisYizhe Wang0Luxiang Zhao1Zhuozhao Zheng2Yu Zhang3Department of RadiologySchool of Mechanical EngineeringDepartment of RadiologySchool of MedicineCirrhosis-induced clinically significant portal hypertension (CSPH) is a fatal disease. Early detection of CSPH is vitally important to reduce the patients’ mortality rate. In this study, combined with three-dimensional image construction technology and computational fluid dynamics (CFD), an image-based flow resistance analysis was proposed. The flow resistance analysis was performed for nine cirrhosis patients with CSPH and ten participants without liver diseases, respectively. The results showed that the flow resistance coefficient of the portal vein system in CSPH patients was significantly lower than that in the control group (0.97 ± 0.11 Pa/(mL/s) for CSPH patients; 1.80 ± 0.40 Pa/(mL/s) for the control group; P=0.028). In contrast, although main portal vein dilation was found in CSPH patients, the cross-sectional area enlargement was not statistically significant (186.01 ± 57.48 mm2 for CSPH patients; 166.26 ± 33.74 mm2 for the control group; P=0.39). The research outcomes indicated that the flow resistance analysis was more sensitive than the commonly used vessel size measurement in the detection of CSPH. In summary, we suggest using flow resistance analysis as a supplementary noninvasive method to detect cirrhosis patients with CSPH.http://dx.doi.org/10.1155/2022/9396371 |
| spellingShingle | Yizhe Wang Luxiang Zhao Zhuozhao Zheng Yu Zhang Flow Resistance Analysis of Clinically Significant Portal Hypertension in Patients with Liver Cirrhosis Canadian Journal of Gastroenterology and Hepatology |
| title | Flow Resistance Analysis of Clinically Significant Portal Hypertension in Patients with Liver Cirrhosis |
| title_full | Flow Resistance Analysis of Clinically Significant Portal Hypertension in Patients with Liver Cirrhosis |
| title_fullStr | Flow Resistance Analysis of Clinically Significant Portal Hypertension in Patients with Liver Cirrhosis |
| title_full_unstemmed | Flow Resistance Analysis of Clinically Significant Portal Hypertension in Patients with Liver Cirrhosis |
| title_short | Flow Resistance Analysis of Clinically Significant Portal Hypertension in Patients with Liver Cirrhosis |
| title_sort | flow resistance analysis of clinically significant portal hypertension in patients with liver cirrhosis |
| url | http://dx.doi.org/10.1155/2022/9396371 |
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