Antimicrobial and anti-quorum sensing activities of giant fennel (ferula elaeochytris korovin) from the hatay region
<b>Aim: </b>Today, increasing antibiotic resistance has focused the science world on the discovery of new antimicrobial molecules or the development of alternative methods of struggle. One of the alternative methods is thought to be inhibition of bacterial quorum sensing (QS). Because th...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2020-10-01
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1300 |
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| Summary: | <b>Aim: </b>Today, increasing antibiotic resistance has focused the science world on
the discovery of new antimicrobial molecules or the development of alternative
methods of struggle. One of the alternative methods is thought to be inhibition
of bacterial quorum sensing (QS). Because the QS system performs a
crucial part in the synthesis of virulence factors in bacteria. Numerous medicinal
plants are known to have promising antimicrobial and anti-QS activities.
One of these plants may be giant fennel (Ferula elaeochytris Korovin), which
has been extensively used in Anatolia for years. Therefore, it was aimed to investigate
the antimicrobial and anti-QS activities of the root extract of F. elaeochytris
Korovin in this study. <p>
<b>Materials and Methods:</b> The antimicrobial activity of the extract was screened
by disc diffusion assay against various microorganisms. Minimum inhibitory
concentration (MIC) and minimum bactericidal concentration (MBC) of
the extract against sensitive strain(s) were determined using broth microdilution
assay. Anti-QS activity investigated on inhibition of violacein and pyocyanin
production in Chromobacterium violaceum and Pseudomonas aeruginosa
bioreporter strains, respectively.<p>
<b>Results:</b> The extract exhibited the antimicrobial activity against only Staphylococcus
aureus (zone of inhibition (ZOI) = 9.3±0.6 mm). The MIC and the
MBC values were determined as 4.4±1.9 mg/mL and >105 mg/mL, respectively.
No inhibition of violacein production was detected. Pyocyanin production
was reduced by 60% and 82% at sub-MIC concentrations (at 1.64 mg/mL and
3.28 mg/mL, respectively) as against the control (p<0.05) without suppressing
bacterial growth.<p>
<b>Conclusion:</b> This study shows that the root extract of F. elaeochytris Korovin
may be a good candidate to develop antistaphylococcal and anti-QS agents. |
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| ISSN: | 1309-6958 2146-1953 |