Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial
Background/Aims. Low serum folate levels can alter inflammatory reactions. Both phenomena have been linked to Alzheimer’s disease (AD), but the effect of folic acid on AD itself is unclear. We quantified folate supplementation’s effect on inflammation and cognitive function in patients with AD over...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/5912146 |
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| author | Hui Chen Shuai Liu Lu Ji Tianfeng Wu Yong Ji Yuying Zhou Miaoyan Zheng Meilin Zhang Weili Xu Guowei Huang |
| author_facet | Hui Chen Shuai Liu Lu Ji Tianfeng Wu Yong Ji Yuying Zhou Miaoyan Zheng Meilin Zhang Weili Xu Guowei Huang |
| author_sort | Hui Chen |
| collection | DOAJ |
| description | Background/Aims. Low serum folate levels can alter inflammatory reactions. Both phenomena have been linked to Alzheimer’s disease (AD), but the effect of folic acid on AD itself is unclear. We quantified folate supplementation’s effect on inflammation and cognitive function in patients with AD over the course of 6 months. Methods. Patients newly diagnosed with AD (age > 60 years; n=121; mild to severe; international criteria) and being treated with donepezil were randomly assigned into two groups with (intervention group) or without (control group) supplemental treatment with folic acid (1.25 mg/d) for 6 months. The Mini-Mental State Examination (MMSE) was administered to all patients at baseline and follow-up, and blood samples were taken before and after treatment. We quantified serum folate, amyloid beta (Aβ), interleukin-6 (IL-6), tumor necrosis factor α (TNFα), plasma homocysteine (Hcy), S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), and the mRNA levels of presenilin (PS), IL-6, and TNFα in leukocytes. Data were analyzed using a repeated-measures mixed model. Results. The mean MMSE was slightly increased in the intervention group compared to that in the control group (P<0.05). Posttreatment, plasma SAM and SAM/SAH levels were significantly higher (P<0.05), while Aβ40, PS1-mRNA, and TNFα-mRNA levels were lower in the intervention group than in the control group (P<0.05). The Aβ42/Aβ40 ratio was also higher in the intervention group (P<0.05). Conclusions. Folic acid is beneficial in patients with AD. Inflammation may play an important role in the interaction between folic acid and AD. This trial is registered with clinical trial registration number ChiCTR-TRC-13003246. |
| format | Article |
| id | doaj-art-e8dbf2a65e8b442885ece97e16cb6ff0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e8dbf2a65e8b442885ece97e16cb6ff02025-02-03T01:30:52ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/59121465912146Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled TrialHui Chen0Shuai Liu1Lu Ji2Tianfeng Wu3Yong Ji4Yuying Zhou5Miaoyan Zheng6Meilin Zhang7Weili Xu8Guowei Huang9School of Nursing, Tianjin Medical University, Tianjin, ChinaDepartment of Neurology, Huanhu Hospital, Tianjin, ChinaDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, ChinaDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, ChinaDepartment of Neurology, Huanhu Hospital, Tianjin, ChinaDepartment of Neurology, Huanhu Hospital, Tianjin, ChinaMetabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin, ChinaDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, ChinaAging Research Centre, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, SwedenDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, ChinaBackground/Aims. Low serum folate levels can alter inflammatory reactions. Both phenomena have been linked to Alzheimer’s disease (AD), but the effect of folic acid on AD itself is unclear. We quantified folate supplementation’s effect on inflammation and cognitive function in patients with AD over the course of 6 months. Methods. Patients newly diagnosed with AD (age > 60 years; n=121; mild to severe; international criteria) and being treated with donepezil were randomly assigned into two groups with (intervention group) or without (control group) supplemental treatment with folic acid (1.25 mg/d) for 6 months. The Mini-Mental State Examination (MMSE) was administered to all patients at baseline and follow-up, and blood samples were taken before and after treatment. We quantified serum folate, amyloid beta (Aβ), interleukin-6 (IL-6), tumor necrosis factor α (TNFα), plasma homocysteine (Hcy), S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), and the mRNA levels of presenilin (PS), IL-6, and TNFα in leukocytes. Data were analyzed using a repeated-measures mixed model. Results. The mean MMSE was slightly increased in the intervention group compared to that in the control group (P<0.05). Posttreatment, plasma SAM and SAM/SAH levels were significantly higher (P<0.05), while Aβ40, PS1-mRNA, and TNFα-mRNA levels were lower in the intervention group than in the control group (P<0.05). The Aβ42/Aβ40 ratio was also higher in the intervention group (P<0.05). Conclusions. Folic acid is beneficial in patients with AD. Inflammation may play an important role in the interaction between folic acid and AD. This trial is registered with clinical trial registration number ChiCTR-TRC-13003246.http://dx.doi.org/10.1155/2016/5912146 |
| spellingShingle | Hui Chen Shuai Liu Lu Ji Tianfeng Wu Yong Ji Yuying Zhou Miaoyan Zheng Meilin Zhang Weili Xu Guowei Huang Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial Mediators of Inflammation |
| title | Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial |
| title_full | Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial |
| title_fullStr | Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial |
| title_full_unstemmed | Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial |
| title_short | Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial |
| title_sort | folic acid supplementation mitigates alzheimer s disease by reducing inflammation a randomized controlled trial |
| url | http://dx.doi.org/10.1155/2016/5912146 |
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