The influence of intestinal microbiota on the development of type 1 diabetes
Introduction and purpose Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of pancreatic β cells, which leads to insulin deficiency and hyperglycemia. One significant factor that may influence the development of type 1 diabetes is a change in the intestinal microbiota...
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Kazimierz Wielki University
2024-11-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/56167 |
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| author | Katarzyna Augustowska Agnieszka Protasiuk Rafał Sierzpowski Patrycja Tymoszuk Agata Żak |
| author_facet | Katarzyna Augustowska Agnieszka Protasiuk Rafał Sierzpowski Patrycja Tymoszuk Agata Żak |
| author_sort | Katarzyna Augustowska |
| collection | DOAJ |
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Introduction and purpose
Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of pancreatic β cells, which leads to insulin deficiency and hyperglycemia. One significant factor that may influence the development of type 1 diabetes is a change in the intestinal microbiota. This study aim is to present the significance and role of intestinal microbiota in the pathogenesis of T1D. This subject is important, as it offers prospects for new therapeutic solutions, especially given the significant social impact of T1D.
Description
Type 1 diabetes (T1D) causes a number of symptoms and complications, including an increased risk of developing cardiovascular diseases. Diagnosis includes measurements of glucose concentration, glycated hemoglobin, and specific antibodies in the blood. The basic therapy for T1D is insulin replacement therapy. Numerous studies have shown that both the composition and function of the intestinal microbiota are impaired in patients with T1D. It has been observed that an increase in the number of Bacterioides and a decrease in the number of Firmicutes, which are the main microorganisms of the intestinal microbiome, are correlated with a high risk of developing T1D.
Summary
Type 1 Diabetes (T1D) is a serious health problem that affects many people worldwide and the incidence of the disease is constantly increasing. There is a growing number of studies that emphasize the influence of the intestinal microbiota on the development of T1D. It is important to enlarge our knowledge about this disease. Further studies are needed to determine the importance and the role of the intestinal microbiota in the pathogenesis of T1D.
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| format | Article |
| id | doaj-art-e8dab1210e4544389667fcfc61b084e0 |
| institution | DOAJ |
| issn | 2391-8306 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-e8dab1210e4544389667fcfc61b084e02025-08-20T02:48:30ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062024-11-017510.12775/JEHS.2024.75.56167The influence of intestinal microbiota on the development of type 1 diabetesKatarzyna Augustowska0Agnieszka Protasiuk1Rafał Sierzpowski2Patrycja Tymoszuk3Agata Żak4Stefan Cardinal Wyszyński Provincial Specialist Hospital SPZOZ in Lublin, PolandMazovian Voivodeship Hospital of John Paul II in Siedlce Sp. z o.o.Stefan Cardinal Wyszyński Provincial Specialist Hospital SPZOZ in Lublin, PolandStefan Cardinal Wyszyński Provincial Specialist Hospital SPZOZ in Lublin, PolandStefan Cardinal Wyszyński Provincial Specialist Hospital SPZOZ in Lublin Introduction and purpose Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of pancreatic β cells, which leads to insulin deficiency and hyperglycemia. One significant factor that may influence the development of type 1 diabetes is a change in the intestinal microbiota. This study aim is to present the significance and role of intestinal microbiota in the pathogenesis of T1D. This subject is important, as it offers prospects for new therapeutic solutions, especially given the significant social impact of T1D. Description Type 1 diabetes (T1D) causes a number of symptoms and complications, including an increased risk of developing cardiovascular diseases. Diagnosis includes measurements of glucose concentration, glycated hemoglobin, and specific antibodies in the blood. The basic therapy for T1D is insulin replacement therapy. Numerous studies have shown that both the composition and function of the intestinal microbiota are impaired in patients with T1D. It has been observed that an increase in the number of Bacterioides and a decrease in the number of Firmicutes, which are the main microorganisms of the intestinal microbiome, are correlated with a high risk of developing T1D. Summary Type 1 Diabetes (T1D) is a serious health problem that affects many people worldwide and the incidence of the disease is constantly increasing. There is a growing number of studies that emphasize the influence of the intestinal microbiota on the development of T1D. It is important to enlarge our knowledge about this disease. Further studies are needed to determine the importance and the role of the intestinal microbiota in the pathogenesis of T1D. https://apcz.umk.pl/JEHS/article/view/56167diabetestype 1 diabetesT1Dgut microbiotagut microbiota and type 1 diabetes |
| spellingShingle | Katarzyna Augustowska Agnieszka Protasiuk Rafał Sierzpowski Patrycja Tymoszuk Agata Żak The influence of intestinal microbiota on the development of type 1 diabetes Journal of Education, Health and Sport diabetes type 1 diabetes T1D gut microbiota gut microbiota and type 1 diabetes |
| title | The influence of intestinal microbiota on the development of type 1 diabetes |
| title_full | The influence of intestinal microbiota on the development of type 1 diabetes |
| title_fullStr | The influence of intestinal microbiota on the development of type 1 diabetes |
| title_full_unstemmed | The influence of intestinal microbiota on the development of type 1 diabetes |
| title_short | The influence of intestinal microbiota on the development of type 1 diabetes |
| title_sort | influence of intestinal microbiota on the development of type 1 diabetes |
| topic | diabetes type 1 diabetes T1D gut microbiota gut microbiota and type 1 diabetes |
| url | https://apcz.umk.pl/JEHS/article/view/56167 |
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