Extravascular coagulation regulates haemostasis independently of activated platelet surfaces in an in vivo mouse model

Abstract While the conventional understanding of haemostatic plug formation is that coagulation proceeds efficiently on the surface of activated platelets at the vascular injury site to form a robust haemostatic plug, this understanding does not explain the clinical reality that platelet dysfunction...

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Bibliographic Details
Main Authors: Asuka Sakata, Kohei Tatsumi, Naoki Matsumoto, Nigel Mackman, Suguru Harada, Ryohei Kawasaki, Yukiko Okuyama-Nishida, Tetsuhiro Soeda, Keiji Nogami, Midori Shima
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07838-x
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