LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS
Oxidative stress is an acknowledged pathogenic mechanism in Type 1 diabetes mellitus. Acute increases in plasma glucose concentration may increase free radical production by the following mechanisms: labile glycation; auto-oxidation of glucose, and intracellular activation of the polyol pathway; whi...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2013-07-01
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| Series: | Acta Biomedica Scientifica |
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| Online Access: | https://www.actabiomedica.ru/jour/article/view/1618 |
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| author | L. I. Kolesnikova M. A. Darenskaya L. A. Grebenkina T. P. Bardymova S. V. Gnusina N. V. Semenova |
| author_facet | L. I. Kolesnikova M. A. Darenskaya L. A. Grebenkina T. P. Bardymova S. V. Gnusina N. V. Semenova |
| author_sort | L. I. Kolesnikova |
| collection | DOAJ |
| description | Oxidative stress is an acknowledged pathogenic mechanism in Type 1 diabetes mellitus. Acute increases in plasma glucose concentration may increase free radical production by the following mechanisms: labile glycation; auto-oxidation of glucose, and intracellular activation of the polyol pathway; which produces an imbalance in the NADh/NAD+ ratio and favours the production of free radicals. Incidence, severity, and rate of complications of Type 1 diabetes mellitus are associated with many factors including geographic location and ethnicity. The main features of lipid peroxidation in 30 women with type 1 diabetes in Buryat and Russian ethnic groups were examined. The materials for biochemical studies were blood serum and red cells. The content of the substrates and products of lipid peroxidation (diene conjugates, ketodienes and coupled trienes, malondialdehyde), total antioxidant activity of serum and its components (superoxide dismutase, α-tocopherol, retinol, reduced and oxidized glutathione) were evaluated by a spectrofluorophotometer «SHIMADZU-1501» (Japan). Statistical analysis was performed by non-parametric tests. It is shown that the intensity of lipid peroxidation processes in patients Buryat ethnic group is reduced in comparison with Russian ethnic group, that confirmed by the values of the coefficient of oxidative stress. The study was supported by grants of the President of the Council of the Russian Federation (Scientific School 494.2012.7). |
| format | Article |
| id | doaj-art-e8d77de90da74a8f96ea6c123324dae8 |
| institution | Kabale University |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| publishDate | 2013-07-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj-art-e8d77de90da74a8f96ea6c123324dae82025-08-20T03:56:54ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962013-07-01041311351564LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTSL. I. Kolesnikova0M. A. Darenskaya1L. A. Grebenkina2T. P. Bardymova3S. V. Gnusina4N. V. Semenova5Scientific Center of Family Health and Human Reproduction Problems SB RAMSScientific Center of Family Health and Human Reproduction Problems SB RAMSScientific Center of Family Health and Human Reproduction Problems SB RAMSIrkutsk State Medical Academy of Postgraduate EducationScientific Center of Family Health and Human Reproduction Problems SB RAMSScientific Center of Family Health and Human Reproduction Problems SB RAMSOxidative stress is an acknowledged pathogenic mechanism in Type 1 diabetes mellitus. Acute increases in plasma glucose concentration may increase free radical production by the following mechanisms: labile glycation; auto-oxidation of glucose, and intracellular activation of the polyol pathway; which produces an imbalance in the NADh/NAD+ ratio and favours the production of free radicals. Incidence, severity, and rate of complications of Type 1 diabetes mellitus are associated with many factors including geographic location and ethnicity. The main features of lipid peroxidation in 30 women with type 1 diabetes in Buryat and Russian ethnic groups were examined. The materials for biochemical studies were blood serum and red cells. The content of the substrates and products of lipid peroxidation (diene conjugates, ketodienes and coupled trienes, malondialdehyde), total antioxidant activity of serum and its components (superoxide dismutase, α-tocopherol, retinol, reduced and oxidized glutathione) were evaluated by a spectrofluorophotometer «SHIMADZU-1501» (Japan). Statistical analysis was performed by non-parametric tests. It is shown that the intensity of lipid peroxidation processes in patients Buryat ethnic group is reduced in comparison with Russian ethnic group, that confirmed by the values of the coefficient of oxidative stress. The study was supported by grants of the President of the Council of the Russian Federation (Scientific School 494.2012.7).https://www.actabiomedica.ru/jour/article/view/1618type 1 diabeteslipid peroxidationethnic group |
| spellingShingle | L. I. Kolesnikova M. A. Darenskaya L. A. Grebenkina T. P. Bardymova S. V. Gnusina N. V. Semenova LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS Acta Biomedica Scientifica type 1 diabetes lipid peroxidation ethnic group |
| title | LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS |
| title_full | LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS |
| title_fullStr | LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS |
| title_full_unstemmed | LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS |
| title_short | LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS |
| title_sort | lipid peroxidation system in type 1 diabetes ethnic aspects |
| topic | type 1 diabetes lipid peroxidation ethnic group |
| url | https://www.actabiomedica.ru/jour/article/view/1618 |
| work_keys_str_mv | AT likolesnikova lipidperoxidationsystemintype1diabetesethnicaspects AT madarenskaya lipidperoxidationsystemintype1diabetesethnicaspects AT lagrebenkina lipidperoxidationsystemintype1diabetesethnicaspects AT tpbardymova lipidperoxidationsystemintype1diabetesethnicaspects AT svgnusina lipidperoxidationsystemintype1diabetesethnicaspects AT nvsemenova lipidperoxidationsystemintype1diabetesethnicaspects |