Common Haplotypes within the Chromosome 1q31.3 Region Determine Systemic Concentrations of the Entire Complement Factor H Protein Family

Common Haplotypes within the Chromosome 1q31.3 Region Determine Systemic Concentrations of the Entire Complement Factor H Protein Family

Introduction: The alternative pathway of complement activation is consistently active, keeping the complement system primed for immediate response. This constant “tick-over” mechanism is regulated by the factor H (FH) protein family, which encompasses seven highly related proteins: FH, FH...

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Main Authors: Bert R.J. Veuskens, Mara van Rossum, Emi Cattenstart, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Karin van Leeuwen, Jin Liu, Robert A. Anstadt, Burt T. Richards, Gregory S. Hageman, Taco W. Kuijpers, Erik J.M. Toonen, Richard B. Pouw
Format: Article
Language:English
Published: Karger Publishers 2025-01-01
Series:Journal of Innate Immunity
Online Access:https://karger.com/article/doi/10.1159/000545342
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